PMID- 34475099
OWN - NLM
STAT- MEDLINE
DCOM- 20211229
LR  - 20221207
IS  - 1939-327X (Electronic)
IS  - 0012-1797 (Linking)
VI  - 70
IP  - 11
DP  - 2021 Nov
TI  - Effect of Systemic Hypertension on Peripapillary RNFL Thickness in Patients With 
      Diabetes Without Diabetic Retinopathy.
PG  - 2663-2667
LID - 10.2337/db21-0491 [doi]
AB  - Type 2 diabetes mellitus (T2DM) and hypertension (HTN) are both relatively common 
      systemic diseases and cause damage to the retina, such as inner retina reduction 
      and microvascular impairment. The purpose of this study was to identify 
      peripapillary retinal nerve fiber layer (pRNFL) damage by diabetic 
      neurodegeneration and the effects of HTN on the pRNFL thickness in patients with 
      T2DM without clinical diabetic retinopathy. Subjects were divided into three 
      groups: healthy control subjects (group 1), patients with T2DM (group 2), and 
      patients with both diabetes and HTN (group 3). The pRNFL thickness was measured 
      using optical coherence tomography and compared among each group. Linear 
      regression analyses were performed to identify factors associated with pRNFL 
      thickness. A total of 325 eyes were included: 143 eyes in the group 1, 126 eyes 
      in group 2, and 56 eyes in group 3. The mean pRNFL thicknesses of each group were 
      96.1 +/- 7.7, 94.4 +/- 8.6, and 91.6 +/- 9.6 mum, respectively (P = 0.003). In 
      multivariate linear analyses, diabetes duration (beta = -0.236; P = 0.018) and HTN 
      (beta = -3.766; P = 0.008) were significant factors affecting the pRNFL thickness in 
      groups 2 and 3. Additionally, the HTN duration was significantly correlated with 
      pRNFL thickness in group 3 (R (2) = 0.121; P = 0.008). In conclusion, patients 
      with T2DM with HTN showed thinner pRNFL thickness than those with T2DM only. 
      Additionally, the duration of HTN was significantly correlated with pRNFL 
      thickness in patients with both diabetes and HTN.
CI  - (c) 2021 by the American Diabetes Association.
FAU - Lee, Min-Woo
AU  - Lee MW
AD  - Department of Ophthalmology, Konyang University College of Medicine, Daejeon, 
      Republic of Korea.
FAU - Park, Gi-Seok
AU  - Park GS
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Lim, Hyung-Bin
AU  - Lim HB
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Lee, Woo-Hyuk
AU  - Lee WH
AD  - Department of Ophthalmology, Gyeongsang National University Changwon Hospital, 
      Daejeon, Republic of Korea.
FAU - Kim, Min-Su
AU  - Kim MS
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Lee, Young-Hoon
AU  - Lee YH
AD  - Department of Ophthalmology, Konyang University College of Medicine, Daejeon, 
      Republic of Korea.
FAU - Kim, Jung-Yeul
AU  - Kim JY
AUID- ORCID: 0000-0003-3679-1310
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea kimjy@cnu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20210902
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*pathology
MH  - Diabetic Retinopathy/*pathology
MH  - Female
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Hypertension/*pathology
MH  - Male
MH  - Middle Aged
MH  - Retinal Neurons/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Acuity
EDAT- 2021/09/04 06:00
MHDA- 2021/12/30 06:00
CRDT- 2021/09/03 05:57
PHST- 2021/06/02 00:00 [received]
PHST- 2021/08/25 00:00 [accepted]
PHST- 2021/09/04 06:00 [pubmed]
PHST- 2021/12/30 06:00 [medline]
PHST- 2021/09/03 05:57 [entrez]
AID - db21-0491 [pii]
AID - 10.2337/db21-0491 [doi]
PST - ppublish
SO  - Diabetes. 2021 Nov;70(11):2663-2667. doi: 10.2337/db21-0491. Epub 2021 Sep 2.