PMID- 34475444
OWN - NLM
STAT- MEDLINE
DCOM- 20211207
LR  - 20211214
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Sep 2
TI  - The fate of methylmercury through the formation of bismethylmercury sulfide as an 
      intermediate in mice.
PG  - 17598
LID - 10.1038/s41598-021-96579-y [doi]
LID - 17598
AB  - A previous study by our group indicated that methylmercury (MeHg) is 
      biotransformed to bismethylmercury sulfide [(MeHg)(2)S)] by interaction with 
      reactive sulfur species (RSS) produced in the body. In the present study, we 
      explored the transformation of MeHg to (MeHg)(2)S in the gut and the subsequent 
      fate of (MeHg)(2)S in vitro and in vivo. An ex vivo experiment suggested the 
      possibility of the extracellular transformation of MeHg to (MeHg)(2)S in the 
      distal colon, and accordingly, the MeHg sulfur adduct was detected in the 
      intestinal contents and feces of mice administered MeHg, suggesting that 
      (MeHg)(2)S is formed through reactions between MeHg and RSS in the gut. In a 
      cell-free system, we found that (MeHg)(2)S undergoes degradation in a 
      time-dependent manner, resulting in the formation of mercury sulfide and 
      dimethylmercury (DMeHg), as determined by X-ray diffraction and gas 
      chromatography/mass spectrometry, respectively. We also identified DMeHg in the 
      expiration after the intraperitoneal administration of (MeHg)(2)S to mice. Thus, 
      our present study identified a new fate of MeHg through (MeHg)(2)S as an 
      intermediate, which leads to conversion of volatile DMeHg in the body.
CI  - (c) 2021. The Author(s).
FAU - Abiko, Yumi
AU  - Abiko Y
AD  - Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 
      305-8575, Japan.
FAU - Katayama, Yusuke
AU  - Katayama Y
AD  - Master's Program in Medical Sciences, Graduate School of Comprehensive Human 
      Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
FAU - Zhao, Wenyang
AU  - Zhao W
AD  - Doctoral Program in Materials Science and Engineering, Graduate School of Pure 
      and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-0006, Japan.
AD  - National Institute for Materials Science, Tsukuba, Ibaraki, 305-0047, Japan.
FAU - Horai, Sawako
AU  - Horai S
AD  - Environmental Health Section, Department Environment and Public Health, National 
      Institute for Minamata Disease, Minamata, Kumamoto, 867-0008, Japan.
FAU - Sakurai, Kenji
AU  - Sakurai K
AD  - Doctoral Program in Materials Science and Engineering, Graduate School of Pure 
      and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-0006, Japan.
AD  - National Institute for Materials Science, Tsukuba, Ibaraki, 305-0047, Japan.
FAU - Kumagai, Yoshito
AU  - Kumagai Y
AD  - Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 
      305-8575, Japan. yk-em-tu@md.tsukuba.ac.jp.
AD  - Master's Program in Medical Sciences, Graduate School of Comprehensive Human 
      Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan. 
      yk-em-tu@md.tsukuba.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210902
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Methylmercury Compounds)
RN  - 54277-95-1 (methylmercury sulfide)
SB  - IM
MH  - Animals
MH  - Biotransformation
MH  - Female
MH  - Intestinal Mucosa/*metabolism
MH  - Liver/*metabolism
MH  - Methylmercury Compounds/analysis/metabolism/*pharmacokinetics
MH  - Mice
MH  - Mice, Inbred C57BL
PMC - PMC8413320
COIS- The authors declare no competing interests.
EDAT- 2021/09/04 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/09/02
CRDT- 2021/09/03 06:21
PHST- 2021/04/23 00:00 [received]
PHST- 2021/07/13 00:00 [accepted]
PHST- 2021/09/03 06:21 [entrez]
PHST- 2021/09/04 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/09/02 00:00 [pmc-release]
AID - 10.1038/s41598-021-96579-y [pii]
AID - 96579 [pii]
AID - 10.1038/s41598-021-96579-y [doi]
PST - epublish
SO  - Sci Rep. 2021 Sep 2;11(1):17598. doi: 10.1038/s41598-021-96579-y.