PMID- 34476821
OWN - NLM
STAT- MEDLINE
DCOM- 20211013
LR  - 20220201
IS  - 1365-2036 (Electronic)
IS  - 0269-2813 (Linking)
VI  - 54
IP  - 8
DP  - 2021 Oct
TI  - The long-term risk for myocardial infarction or stroke after proton pump 
      inhibitor therapy (2008-2018).
PG  - 1033-1040
LID - 10.1111/apt.16565 [doi]
AB  - BACKGROUND: Proton pump inhibitors (PPIs) are well tolerated in the short term 
      but have recently been associated with increased long-term cardiovascular risk in 
      observational studies. AIMS: To evaluate long-term risks of myocardial infarction 
      (MI) and ischaemic stroke (IS) associated with PPI vs H(2) -receptor antagonist 
      (H(2) RA) therapy in adults without pre-existing cardiovascular or 
      cerebrovascular disease METHODS: Using administrative claims data (2008-2018), we 
      emulated a target trial comparing MI and IS risks in new users of PPIs vs H(2) 
      RAs. Treatment was identified using dispensed prescriptions. MI and IS were 
      defined using hospital discharge codes. Inverse probability weighting was used to 
      adjust for confounding, and Cox models to estimate hazard ratios (HRs). Survival 
      curves were estimated using weighted Kaplan-Meier estimators. RESULTS: We 
      identified 1 143 948 new users of PPIs and 36 229 new users of H(2) RAs who were 
      free of prevalent cardiovascular or cerebrovascular disease. The mean follow-up 
      time was 6.2 years for PPI initiators and 5.3 years for H(2) RA initiators. After 
      10 years, the HRs for MI and IS were 0.96 (95% confidence interval (CI): 
      0.80-1.16) and 0.98 (95% CI: 0.89-1.08), respectively. CONCLUSIONS: This analysis 
      of claims data of a large German health insurer did not provide evidence that PPI 
      therapy increased the risk of MI or IS in the first decade after treatment 
      initiation.
CI  - (c) 2021 The Authors. Alimentary Pharmacology & Therapeutics published by John 
      Wiley & Sons Ltd.
FAU - Nolde, Michael
AU  - Nolde M
AUID- ORCID: 0000-0001-6893-7367
AD  - Institute for Medical Information Processing, Biometry, and Epidemiology - IBE, 
      LMU Munich, Munich, Germany.
AD  - Chair of Epidemiology, University of Augsburg, at University Hospital Augsburg, 
      Augsburg, Germany.
FAU - Ahn, Nayeon
AU  - Ahn N
AUID- ORCID: 0000-0003-4414-114X
AD  - Institute for Medical Information Processing, Biometry, and Epidemiology - IBE, 
      LMU Munich, Munich, Germany.
AD  - Chair of Epidemiology, University of Augsburg, at University Hospital Augsburg, 
      Augsburg, Germany.
FAU - Dreischulte, Tobias
AU  - Dreischulte T
AD  - Department of General Practice and Family Medicine, LMU Munich, Munich, Germany.
FAU - Ruckert-Eheberg, Ina-Maria
AU  - Ruckert-Eheberg IM
AUID- ORCID: 0000-0001-5418-283X
AD  - Institute for Medical Information Processing, Biometry, and Epidemiology - IBE, 
      LMU Munich, Munich, Germany.
AD  - Chair of Epidemiology, University of Augsburg, at University Hospital Augsburg, 
      Augsburg, Germany.
AD  - Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Centre for 
      Environmental Health, Neuherberg, Germany.
FAU - Guntner, Florian
AU  - Guntner F
AD  - Bereich Versorgungsmanagement, AOK Bayern, Munich, Germany.
FAU - Gunter, Alexander
AU  - Gunter A
AD  - Bereich Versorgungsmanagement, AOK Bayern, Munich, Germany.
FAU - Gerlach, Roman
AU  - Gerlach R
AD  - Association of Statutory Health Insurance Physicians in Bavaria (Kassenarztliche 
      Vereinigung Bayerns, KVB), Munich, Germany.
FAU - Tauscher, Martin
AU  - Tauscher M
AD  - Association of Statutory Health Insurance Physicians in Bavaria (Kassenarztliche 
      Vereinigung Bayerns, KVB), Munich, Germany.
FAU - Amann, Ute
AU  - Amann U
AD  - Independent Research Group Clinical Epidemiology, Helmholtz Zentrum Munchen, 
      German Research Centre for Environmental Health, Neuherberg, Germany.
FAU - Linseisen, Jakob
AU  - Linseisen J
AD  - Institute for Medical Information Processing, Biometry, and Epidemiology - IBE, 
      LMU Munich, Munich, Germany.
AD  - Chair of Epidemiology, University of Augsburg, at University Hospital Augsburg, 
      Augsburg, Germany.
AD  - Independent Research Group Clinical Epidemiology, Helmholtz Zentrum Munchen, 
      German Research Centre for Environmental Health, Neuherberg, Germany.
FAU - Meisinger, Christa
AU  - Meisinger C
AD  - Chair of Epidemiology, University of Augsburg, at University Hospital Augsburg, 
      Augsburg, Germany.
FAU - Baumeister, Sebastian-Edgar
AU  - Baumeister SE
AD  - Institute of Health Services Research in Dentistry, University of Munster, 
      Munster, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210903
PL  - England
TA  - Aliment Pharmacol Ther
JT  - Alimentary pharmacology & therapeutics
JID - 8707234
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
CIN - Aliment Pharmacol Ther. 2022 Jan;55(1):141-142. PMID: 34907568
CIN - Aliment Pharmacol Ther. 2022 Jan;55(1):139-140. PMID: 34907572
MH  - Adult
MH  - *Brain Ischemia
MH  - Humans
MH  - *Myocardial Infarction/chemically induced/epidemiology
MH  - Proton Pump Inhibitors/adverse effects
MH  - Risk Factors
MH  - *Stroke/chemically induced/epidemiology
EDAT- 2021/09/04 06:00
MHDA- 2021/10/14 06:00
CRDT- 2021/09/03 07:10
PHST- 2021/06/04 00:00 [revised]
PHST- 2021/05/17 00:00 [received]
PHST- 2021/07/29 00:00 [accepted]
PHST- 2021/09/04 06:00 [pubmed]
PHST- 2021/10/14 06:00 [medline]
PHST- 2021/09/03 07:10 [entrez]
AID - 10.1111/apt.16565 [doi]
PST - ppublish
SO  - Aliment Pharmacol Ther. 2021 Oct;54(8):1033-1040. doi: 10.1111/apt.16565. Epub 
      2021 Sep 3.