PMID- 34476918
OWN - NLM
STAT- MEDLINE
DCOM- 20220209
LR  - 20220209
IS  - 1578-1267 (Electronic)
IS  - 0301-0546 (Linking)
VI  - 49
IP  - 5
DP  - 2021
TI  - Fish allergy tolerance 16 months after diagnosis.
PG  - 25-27
LID - 10.15586/aei.v49i5.313 [doi]
AB  - Fish allergy is generally thought to be persistent, and approximately 80% of 
      patients with fish allergies do not develop tolerance even 10 years after 
      diagnosis. There have been no reports of rapid tolerance development in patients 
      with severe fish allergies. We report the development of tolerance 16 months 
      after the diagnosis of fish allergies. A 13-month-old boy was diagnosed with 
      rosefish allergy (Sebastes matsubarae) and Japanese jack mackerel allergy 
      (Trachurus japonicus). To find out which species of fish he could consume safely, 
      he underwent several oral food challenge (OFC) tests. It was determined that he 
      could consume tuna, salmon, cod, sardine, chub mackerel (Scomber japonicus), and 
      Japanese amberjack (Seriola quinqueradiata) without eliciting signs of allergy. 
      He continued to eat the fish that did not produce allergic reactions three to 
      four times a week. The titer of serum allergen-specific immunoglobulin E (IgE) to 
      fish had decreased in a subsequent ImmunoCAP((R))-specific IgE blood test performed 
      16 months after the diagnosis of the rosefish allergy. Following this test 
      result, he underwent OFCs with rosefish and Japanese jack mackerel, both of which 
      turned out to be negative, and it was determined that he had developed tolerance 
      to fish. In this case, the repeated OFCs were useful in identifying fish species 
      that were safe for consumption. In addition, the decrease in allergen-specific 
      IgE was useful in predicting the development of tolerance. We hypothesize that 
      proactive consumption of available fish species may lead to this rapid induction 
      of tolerance to fish allergens.
FAU - Okamoto, Mitsuhiro
AU  - Okamoto M
AD  - Department of Pediatrics, Hyogo Prefectural Tamba Medical Center, Tamba, Japan; 
      m-okamoto@hp.pref.hyogo.jp.
FAU - Takafuji, Satoru
AU  - Takafuji S
AD  - Department of Pediatrics, Hyogo Prefectural Tamba Medical Center, Tamba, Japan.
FAU - Inoue, Shintaro
AU  - Inoue S
AD  - Department of Pediatrics, Hyogo Prefectural Tamba Medical Center, Tamba, Japan.
FAU - Tanaka, Yuya
AU  - Tanaka Y
AD  - Department of Allergy, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210901
PL  - Singapore
TA  - Allergol Immunopathol (Madr)
JT  - Allergologia et immunopathologia
JID - 0370073
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens
MH  - Animals
MH  - Fishes/immunology
MH  - *Food Hypersensitivity/diagnosis
MH  - Humans
MH  - Immunoglobulin E
MH  - Infant
MH  - Male
MH  - Skin Tests
OTO - NOTNLM
OT  - Sebastes
OT  - Trachurus
OT  - food hypersensitivity
OT  - immunoglobulin E (IgE)
OT  - jack mackerel
OT  - oral food challenge
OT  - parvalbumin
OT  - rosefish
EDAT- 2021/09/04 06:00
MHDA- 2022/02/10 06:00
CRDT- 2021/09/03 07:18
PHST- 2021/03/13 00:00 [received]
PHST- 2021/07/14 00:00 [accepted]
PHST- 2021/09/03 07:18 [entrez]
PHST- 2021/09/04 06:00 [pubmed]
PHST- 2022/02/10 06:00 [medline]
AID - 10.15586/aei.v49i5.313 [doi]
PST - epublish
SO  - Allergol Immunopathol (Madr). 2021 Sep 1;49(5):25-27. doi: 
      10.15586/aei.v49i5.313. eCollection 2021.