PMID- 34476921
OWN - NLM
STAT- MEDLINE
DCOM- 20220209
LR  - 20220209
IS  - 1578-1267 (Electronic)
IS  - 0301-0546 (Linking)
VI  - 49
IP  - 5
DP  - 2021
TI  - Laboratory screening test with inhalant and food allergens in atopic Brazilian 
      children and adolescents: a performance.
PG  - 42-48
LID - 10.15586/aei.v49i5.464 [doi]
AB  - The Phadiatop Infant((R)) (PhInf) is a panel developed to assess allergic 
      sensitization (immunoglobulin E [IgE]) in children aged <5 years and combines 
      inhalant and food allergens. The test has not been evaluated outside Europe. This 
      is a cross-sectional study conducted at 11 pediatric allergy centers to evaluate 
      PhInf as an allergic disease screening method in Brazilian children. Children as 
      controls and patients (aged 6 months-18 years) were grouped according to their 
      primary disease and age group. PhInf and specific serum IgE (sIgE) screening was 
      performed for Dermatophagoides pteronyssinus (DP), cat and dog epithelia, a mix 
      of grasses and pollens, eggs, cow's milk, peanuts, and shrimp. Values >/= 0.35 
      kU(A)/L (or PAU/L) were considered positive. A total of 470 children and 
      adolescents, which included 385 patients and 85 controls, participated in the 
      study (47.7% boys, average age: 6.3 years). In all, 72.6% of the participants had 
      positive PhInf test (n = 341), with a higher proportion of those having food 
      allergy (92.6%), atopic dermatitis (91.9%), and those aged >13 years having 
      allergy (95%). The PhInf and sIgE agreement between patients (Kappa = 0.94, P < 
      0.001) and controls (Kappa = 0.84, P < 0.001) was high. PhInf and DP agreement in 
      patients aged >13 years was excellent (Kappa = 0.936, P < 0.001). Compared with 
      sIgE dosage, PhInf had high sensitivity (97%) and specificity (93%). Positivity 
      of PhInf test in this population was high and had an excellent correlation with 
      the allergens comprising the panel. It is a useful method for screening children 
      suspected of having allergic diseases in a non-European country.
FAU - Reali, Ana Carolina Rozalem
AU  - Reali ACR
AD  - Pediatrics Department, Escola Paulista de Medicina, Federal University of Sao 
      Paulo, Sao Paulo, Sao Paulo, Brazil.
FAU - Pierotti, Felipe Faria
AU  - Pierotti FF
AD  - Pediatrics Department, Escola Paulista de Medicina, Federal University of Sao 
      Paulo, Sao Paulo, Sao Paulo, Brazil.
FAU - Aranda, Carolina Sanchez
AU  - Aranda CS
AD  - Pediatrics Department, Escola Paulista de Medicina, Federal University of Sao 
      Paulo, Sao Paulo, Sao Paulo, Brazil; carolaaranda@yahoo.com.br.
FAU - Cocco, Renata Rodrigues
AU  - Cocco RR
AD  - Pediatrics Department, Albert Einstein Israeli Faculty of Health Sciences, Sao 
      Paulo, Sao Paulo, Brazil.
FAU - Sarinho, Emanuel S Cavalcanti
AU  - Sarinho ESC
AD  - Pediatrics Department, Federal University of Pernambuco, Recife, Pernambuco, 
      Brazil.
FAU - Sano, Flavio
AU  - Sano F
AD  - Pediatrics Department, Nipo-Brazilian Hospital, Sao Paulo, Sao Paulo, Brazil.
FAU - Neto, Arnaldo Porto
AU  - Neto AP
AD  - Pediatrics Department, Federal University Fronteira Sul, Passo Fundo, Rio Grande 
      do Sul, Brazil.
FAU - Rosario, Nelson A
AU  - Rosario NA
AD  - Pediatrics Department, Federal University of Parana, Curitiba, Parana, Brazil.
FAU - Neto, Herberto J Chong
AU  - Neto HJC
AD  - Pediatrics Department, Federal University of Parana, Curitiba, Parana, Brazil.
FAU - Goudouris, Ekaterini Simoes
AU  - Goudouris ES
AD  - Pediatrics Department, Federal University of Rio de Janeiro, Rio de Janeiro, Rio 
      de Janeiro, Brazil.
FAU - Moraes, Lilian Sanches
AU  - Moraes LS
AD  - Pediatrics Department, Federal University of Mato Grosso, Cuiaba, Mato Grosso, 
      Brazil.
FAU - Wandalsen, Neusa Falbo
AU  - Wandalsen NF
AD  - Pediatrics Department, Faculty of Medicine, ABC's Foundation, Santo Andre, Sao 
      Paulo, Brazil.
FAU - Pastorino, Antonio Carlos
AU  - Pastorino AC
AD  - Pediatrics Department, University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil.
FAU - Franco, Jackeline Motta
AU  - Franco JM
AD  - Pediatrics Department, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
FAU - Chavarria, Maria Leticia
AU  - Chavarria ML
AD  - Pediatrics Department, Federal University of Goias, Goiania, Goias, Brazil.
FAU - Borres, Magnus P
AU  - Borres MP
AD  - Women's and Children's Health, Thermo Fisher Scientific and Uppsala University, 
      Uppsala, Sweden.
FAU - Sole, Dirceu
AU  - Sole D
AD  - Pediatrics Department, Escola Paulista de Medicina, Federal University of Sao 
      Paulo, Sao Paulo, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20210901
PL  - Singapore
TA  - Allergol Immunopathol (Madr)
JT  - Allergologia et immunopathologia
JID - 0370073
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens
MH  - Animals
MH  - Cats
MH  - Cattle
MH  - Cross-Sectional Studies
MH  - Dogs
MH  - Female
MH  - *Food Hypersensitivity/diagnosis/epidemiology
MH  - Humans
MH  - Immunoglobulin E
MH  - Infant
MH  - *Laboratories
OTO - NOTNLM
OT  - Phadiatop infant
OT  - allergens
OT  - child
OT  - hypersensitivity
OT  - immunoglobulin E
EDAT- 2021/09/04 06:00
MHDA- 2022/02/10 06:00
CRDT- 2021/09/03 07:18
PHST- 2021/05/12 00:00 [received]
PHST- 2021/06/17 00:00 [accepted]
PHST- 2021/09/03 07:18 [entrez]
PHST- 2021/09/04 06:00 [pubmed]
PHST- 2022/02/10 06:00 [medline]
AID - 10.15586/aei.v49i5.464 [doi]
PST - epublish
SO  - Allergol Immunopathol (Madr). 2021 Sep 1;49(5):42-48. doi: 
      10.15586/aei.v49i5.464. eCollection 2021.