PMID- 34477149
OWN - NLM
STAT- MEDLINE
DCOM- 20210913
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 35
DP  - 2021 Sep 3
TI  - Value of shear wave elastography combined with the Toronto clinical scoring 
      system in diagnosis of diabetic peripheral neuropathy.
PG  - e27104
LID - 10.1097/MD.0000000000027104 [doi]
LID - e27104
AB  - To evaluate the diagnostic values of shear wave elastography (SWE) alone and in 
      combination with the Toronto clinical scoring system (TCSS) on diabetic 
      peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM).The 
      study included 41 DPN patients, 42 non-DPN patients, and 21 healthy volunteers. 
      Conventional ultrasonography and SWE were performed on the 2 sides of the tibial 
      nerves, and cross-sectional area (CSA) and nerve stiffness were measured. TCSS 
      was applied to all patients. A receiver operating characteristic curve analysis 
      was performed.The stiffness of the tibial nerve, as measured as mean, minimum or 
      maximum elasticity, was significantly higher in patients in the DPN group than 
      the other groups (P < .05). The tibial nerve of subjects in the non-DPN group was 
      significantly stiffer compared to the control group (P < .05). There was no 
      significant difference of the tibial nerve CSA among the 3 groups (P > .05). Mean 
      elasticity of the tibial nerve with a cutoff of 71.3 kPa was the most sensitive 
      (68.3%) and had a higher area under the curve (0.712; 0.602-0.806) among the 3 
      shear elasticity indices for diagnosing DPN when used alone. When combining SWE 
      with TCSS in diagnosing DPN, the most effective parameter was the EMax, which 
      yielded a sensitivity of 100.00% and a specificity of 95.24%.SWE is a better 
      diagnostic tool for DPN than the conventional ultrasonic parameter CSA, and a 
      higher diagnostic value is attained when combining SWE with TCSS.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Wang, Fei
AU  - Wang F
AD  - Department of Ultrasound, The Second Affiliated Hospital of Soochow University, 
      1055 Sanxiang Road, Suzhou, Jiangsu, China.
FAU - Zheng, Miao
AU  - Zheng M
AD  - Department of Endocrinology, The Second Affiliated Hospital of Soochow 
      University, 1055 Sanxiang Road, Suzhou, Jiangsu, China.
FAU - Hu, Ji
AU  - Hu J
AD  - Department of Endocrinology, The Second Affiliated Hospital of Soochow 
      University, 1055 Sanxiang Road, Suzhou, Jiangsu, China.
FAU - Fang, Chen
AU  - Fang C
AD  - Department of Endocrinology, The Second Affiliated Hospital of Soochow 
      University, 1055 Sanxiang Road, Suzhou, Jiangsu, China.
FAU - Chen, Tong
AU  - Chen T
AD  - Department of Ultrasound, The Second Affiliated Hospital of Soochow University, 
      1055 Sanxiang Road, Suzhou, Jiangsu, China.
FAU - Wang, Meng
AU  - Wang M
AD  - Department of Ultrasound, The Second Affiliated Hospital of Soochow University, 
      1055 Sanxiang Road, Suzhou, Jiangsu, China.
FAU - Zhang, Honghong
AU  - Zhang H
AD  - Department of Endocrinology, The Second Affiliated Hospital of Soochow 
      University, 1055 Sanxiang Road, Suzhou, Jiangsu, China.
FAU - Zhu, Yunyan
AU  - Zhu Y
AD  - Department of Endocrinology, The Second Affiliated Hospital of Soochow 
      University, 1055 Sanxiang Road, Suzhou, Jiangsu, China.
FAU - Song, Xin
AU  - Song X
AD  - Department of Ultrasound, The Second Affiliated Hospital of Soochow University, 
      1055 Sanxiang Road, Suzhou, Jiangsu, China.
FAU - Ma, Qi
AU  - Ma Q
AD  - Department of Ultrasound, The Second Affiliated Hospital of Soochow University, 
      1055 Sanxiang Road, Suzhou, Jiangsu, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/complications/physiopathology
MH  - Diabetic Nephropathies/complications/*diagnostic imaging
MH  - Elasticity Imaging Techniques/methods/*standards/statistics & numerical data
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peripheral Nervous System Diseases/classification/diagnostic imaging
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - *Research Design
PMC - PMC8415960
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2021/09/04 06:00
MHDA- 2021/09/14 06:00
PMCR- 2021/09/03
CRDT- 2021/09/03 08:42
PHST- 2021/01/27 00:00 [received]
PHST- 2021/08/12 00:00 [accepted]
PHST- 2021/09/03 08:42 [entrez]
PHST- 2021/09/04 06:00 [pubmed]
PHST- 2021/09/14 06:00 [medline]
PHST- 2021/09/03 00:00 [pmc-release]
AID - 00005792-202109030-00038 [pii]
AID - MD-D-21-00721 [pii]
AID - 10.1097/MD.0000000000027104 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 Sep 3;100(35):e27104. doi: 
      10.1097/MD.0000000000027104.