PMID- 34478437
OWN - NLM
STAT- MEDLINE
DCOM- 20211116
LR  - 20230920
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 16
IP  - 9
DP  - 2021
TI  - Association between serum lactate dehydrogenase and frailty among individuals 
      with metabolic syndrome.
PG  - e0256315
LID - 10.1371/journal.pone.0256315 [doi]
LID - e0256315
AB  - While metabolic syndrome (MetS) is associated with frailty, the correlation of 
      serum lactate dehydrogenase (sLDH) and frailty with MetS remain uncertain. To 
      investigate the relationship between sLDH and frail components in the US with 
      MetS. A total of 4,066 participants aged 40-90 years were assessed from the 
      database of the third National Health and Nutrition Examination Survey, 
      1988-1994. The participants were classified into MetS and non-MetS groups. 
      Multivariate logistic regression analysis with four models were performed to 
      assess the odds ratio (OR) of the divided tertiles of sLDH levels with frailty, 
      and frail components including slow walking (SW), weakness, exhaustion, low 
      physical activity (LPA), and low body weight (LBW). Higher sLDH levels were 
      positively associated with frailty in the MetS group (p = 0.024) but not in 
      non-MetS group (p = 0.102). After covariate adjustments, the OR of frailty in the 
      upper two tertiles compared to the lowest tertile and revealed statistical 
      significance (p < 0.05). Frail components of SW, weakness, exhaustion, and LPA 
      were associated with higher sLDH (p < 0.05) except for LBW in MetS and non-MetS 
      groups. The results demonstrated the strong association of higher sLDH levels and 
      frailty among US individuals with MetS.
FAU - Chen, Li-Hsiang
AU  - Chen LH
AD  - Division of Family Medicine, Department of Family and Community Medicine, 
      Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan, Republic of China.
AD  - Division of Family Medicine, Department of Family and Community Medicine, 
      Tri-Service General Hospital; and School of Medicine, National Defense Medical 
      Center, Taipei, Taiwan, Republic of China.
FAU - Wu, Li-Wei
AU  - Wu LW
AUID- ORCID: 0000-0003-4744-7646
AD  - Division of Family Medicine, Department of Family and Community Medicine, 
      Tri-Service General Hospital; and School of Medicine, National Defense Medical 
      Center, Taipei, Taiwan, Republic of China.
AD  - Division of Geriatric Medicine, Department of Family and Community Medicine, 
      Tri-Service General Hospital, Taipei, Taiwan, Republic of China.
AD  - Health Management Center, Department of Family and Community Medicine, 
      Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, 
      Republic of China.
AD  - Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, 
      Taiwan, Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210903
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - EC 1.1.- (Lactate Dehydrogenases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Body Weight
MH  - Case-Control Studies
MH  - Female
MH  - Frailty/blood/*epidemiology/pathology
MH  - Humans
MH  - Lactate Dehydrogenases/*blood
MH  - Male
MH  - Metabolic Syndrome/blood/*epidemiology/pathology
MH  - Middle Aged
PMC - PMC8415577
COIS- The authors declared that they had no competing interests.
EDAT- 2021/09/04 06:00
MHDA- 2021/11/17 06:00
PMCR- 2021/09/03
CRDT- 2021/09/03 17:17
PHST- 2021/04/24 00:00 [received]
PHST- 2021/08/03 00:00 [accepted]
PHST- 2021/09/03 17:17 [entrez]
PHST- 2021/09/04 06:00 [pubmed]
PHST- 2021/11/17 06:00 [medline]
PHST- 2021/09/03 00:00 [pmc-release]
AID - PONE-D-21-13637 [pii]
AID - 10.1371/journal.pone.0256315 [doi]
PST - epublish
SO  - PLoS One. 2021 Sep 3;16(9):e0256315. doi: 10.1371/journal.pone.0256315. 
      eCollection 2021.