PMID- 34479060
OWN - NLM
STAT- MEDLINE
DCOM- 20211102
LR  - 20220531
IS  - 1872-8464 (Electronic)
IS  - 0165-5876 (Linking)
VI  - 150
DP  - 2021 Nov
TI  - Protective role of lycopene in experimental allergic rhinitis in rats.
PG  - 110905
LID - S0165-5876(21)00298-6 [pii]
LID - 10.1016/j.ijporl.2021.110905 [doi]
AB  - OBJECTIVE: We investigate whether lycopene has a protective effect in an 
      experimental rat model of allergic rhinitis. METHODS: Experimental animals (65 
      rats) were randomized to 7 groups (Sham-Control, Lycopene 10 mg/kg/day, Lycopene 
      20 mg/kg/day, Intranasal lycopene drops, Intranasal steroid, Corn oil, Allergic 
      Rhinitis). Rats were sensitized by administering of ovalbumin intraperitoneally 
      and intranasally. In addition to ovalbumin; lycopene, corn oil and steroids were 
      given to the relevant groups. Nasal symptom scores of the rats were recorded 
      throughout the study. At end of the study, after intracardiac blood sample 
      collection, all rats were sacrificed, and nasal tissues were examined 
      histopathologically. Serum total immunoglobulin E (IgE) and ovalbumin (OVA) 
      specific IgE were studied from all rats before and after the study. RESULTS: 
      There was a statistically significant increase (p < 0.05) in OVA specific IgE 
      values measured before and after the study in all groups except the sham group. 
      In serum total IgE values; there was a statistically significant increase after 
      treatment in allergic rhinitis, corn oil, lycopene 10 mg and intranasal lycopene 
      drops group, but other groups did not show any significant change. 
      Histopathological study with hematoxylin-eosin staining and cyclooxygenase-2 
      (COX-2), matrix metalloproteinase-9 (MMP-9), vasoactive intestinal peptide (VIP) 
      expression found that lycopene suppresses inflammation with both nasal 
      administration and increased dose. Nasal symptom scores were observed to decrease 
      significantly in all lycopene and steroid groups compared to allergic rihinits 
      and corn groups. CONCLUSION: It was determined that lycopene were effective in 
      the treatment of allergic rhinitis, and this effect was found to be stronger with 
      increasing doses of lycopene.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Polat, Halil
AU  - Polat H
AD  - Yozgat City Hospital, Department of ENT, Turkey. Electronic address: 
      drhalilpolat5@gmail.com.
FAU - Sagit, Mustafa
AU  - Sagit M
AD  - Kayseri Training and Research Hospital, Department of ENT, Turkey.
FAU - Gurgen, Seren Gulsen
AU  - Gurgen SG
AD  - Celal Bayar University School of Vocational Health Service, Department of 
      Histology and Embryology, Turkey.
FAU - Yasar, Mehmet
AU  - Yasar M
AD  - Kayseri Training and Research Hospital, Department of ENT, Turkey.
FAU - Ozcan, Ibrahim
AU  - Ozcan I
AD  - Kayseri Training and Research Hospital, Department of ENT, Turkey.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial, Veterinary
DEP - 20210830
PL  - Ireland
TA  - Int J Pediatr Otorhinolaryngol
JT  - International journal of pediatric otorhinolaryngology
JID - 8003603
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
RN  - SB0N2N0WV6 (Lycopene)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Immunoglobulin E
MH  - Lycopene
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nasal Mucosa
MH  - Ovalbumin
MH  - Rats
MH  - *Rhinitis, Allergic/drug therapy
OTO - NOTNLM
OT  - Allergic
OT  - Animal model
OT  - Experimental
OT  - Lycopene
OT  - Ovalbumin
OT  - Rat
OT  - Rhinitis
OT  - Steroid
EDAT- 2021/09/04 06:00
MHDA- 2021/11/03 06:00
CRDT- 2021/09/03 20:22
PHST- 2021/01/03 00:00 [received]
PHST- 2021/07/08 00:00 [revised]
PHST- 2021/08/28 00:00 [accepted]
PHST- 2021/09/04 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2021/09/03 20:22 [entrez]
AID - S0165-5876(21)00298-6 [pii]
AID - 10.1016/j.ijporl.2021.110905 [doi]
PST - ppublish
SO  - Int J Pediatr Otorhinolaryngol. 2021 Nov;150:110905. doi: 
      10.1016/j.ijporl.2021.110905. Epub 2021 Aug 30.