PMID- 34479452
OWN - NLM
STAT- MEDLINE
DCOM- 20211217
LR  - 20211217
IS  - 2041-3033 (Electronic)
IS  - 0954-4119 (Linking)
VI  - 236
IP  - 2
DP  - 2022 Feb
TI  - Fabrication and biological evaluation of porous beta-TCP bioceramics produced using 
      digital light processing.
PG  - 286-294
LID - 10.1177/09544119211041186 [doi]
AB  - Beta-tricalcium phosphate (beta-TCP) refers to one ideal bone repair substance with 
      good biocompatibility and osteogenicity. A digital light processing (DLP)-system 
      used in this study creates bioceramic green part by stacking up layers of 
      photocurable tricalcium phosphate-filled slurry with various beta-TCP weight 
      fractions. Results show that the sintering shrinkage is anisotropic and the 
      shrinkage vertically reaches over that horizontally. The obtained porous beta-TCP 
      parts have both macroporous outer structure and microporous inner structure, the 
      macropore size is 400-600 mum and the micropore size is 500-1500 nm. The 
      mechanical tests show that the porous beta-TCP bioceramic's compressive strength 
      reaches 16.53 MPa. The cell culture confirmed that the porous beta-TCP bioceramic is 
      capable of achieving the effective attaching, growing, and proliferating 
      pertained to mouse osteoblast cells. This study identified considerable blood 
      vessels and significant ectopic bone forming obviously based on the 
      histologically-related assessment when implanting to rabbit femoral condyle 
      deficiency for 3 months. Thus, under high bioactive property and 
      osteoinductivity, and large precision and mechanical strength that can be 
      adjusted, the DLP printed porous beta-TCP ceramics is capable of being promising for 
      special uses of bones repairing.
FAU - Xu, SongFeng
AU  - Xu S
AUID- ORCID: 0000-0003-3547-1796
AD  - National Cancer Center/National Cancer Clinical Medical Research Center/Chinese 
      Academy of Medical Sciences, Department of Orthopedics, Peking Union Medical 
      College, Beijing, China.
AD  - Department of Orthopedics, National Cancer Center/National Clinical Research 
      Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical 
      Science and Peking Union Medical College, Shenzhen, Guangdong, China.
FAU - Zhang, Hang
AU  - Zhang H
AD  - State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Li, Xiang
AU  - Li X
AD  - State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Zhang, XinXin
AU  - Zhang X
AD  - National Cancer Center/National Cancer Clinical Medical Research Center/Chinese 
      Academy of Medical Sciences, Department of Orthopedics, Peking Union Medical 
      College, Beijing, China.
FAU - Liu, HuanMei
AU  - Liu H
AD  - National Cancer Center/National Cancer Clinical Medical Research Center/Chinese 
      Academy of Medical Sciences, Department of Orthopedics, Peking Union Medical 
      College, Beijing, China.
FAU - Xiong, Yinze
AU  - Xiong Y
AD  - State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Gao, RuiNing
AU  - Gao R
AD  - State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Yu, ShengJi
AU  - Yu S
AD  - National Cancer Center/National Cancer Clinical Medical Research Center/Chinese 
      Academy of Medical Sciences, Department of Orthopedics, Peking Union Medical 
      College, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20210903
PL  - England
TA  - Proc Inst Mech Eng H
JT  - Proceedings of the Institution of Mechanical Engineers. Part H, Journal of 
      engineering in medicine
JID - 8908934
RN  - 0 (Calcium Phosphates)
RN  - 0 (beta-tricalcium phosphate)
SB  - IM
MH  - Animals
MH  - Bone and Bones
MH  - *Calcium Phosphates
MH  - Ceramics
MH  - Compressive Strength
MH  - Mice
MH  - Porosity
MH  - Rabbits
MH  - *Tissue Scaffolds
OTO - NOTNLM
OT  - Digital light processing
OT  - animal study
OT  - cell culture
OT  - ceramic printing
OT  - porous structure
OT  - beta-tricalcium phosphate
EDAT- 2021/09/05 06:00
MHDA- 2021/12/18 06:00
CRDT- 2021/09/04 05:21
PHST- 2021/09/05 06:00 [pubmed]
PHST- 2021/12/18 06:00 [medline]
PHST- 2021/09/04 05:21 [entrez]
AID - 10.1177/09544119211041186 [doi]
PST - ppublish
SO  - Proc Inst Mech Eng H. 2022 Feb;236(2):286-294. doi: 10.1177/09544119211041186. 
      Epub 2021 Sep 3.