PMID- 34479813
OWN - NLM
STAT- MEDLINE
DCOM- 20220328
LR  - 20220401
IS  - 1878-7533 (Electronic)
IS  - 1550-7289 (Linking)
VI  - 17
IP  - 12
DP  - 2021 Dec
TI  - The effect of sleeve ablation of gastric mucosa on body weight and glucose 
      homeostasis in Sprague-Dawley rat model.
PG  - 1984-1994
LID - S1550-7289(21)00388-9 [pii]
LID - 10.1016/j.soard.2021.07.025 [doi]
AB  - BACKGROUND: The gastric mucosa is an important endocrine organ, most of which is 
      resected in sleeve gastrectomy (SG). The effect of removing most of the gastric 
      mucosa has not been studied. OBJECTIVE: To assess the effect of ablating the 
      gastric mucosa (an area proportional to that in SG), on obesity and diabetes in a 
      rat model. SETTING: The Affiliated Hospital of Xuzhou Medical University in 
      Xuzhou Jiangsu, P. R. China. METHODS: Among 34 fatty Sprague-Dawley rats, 26 
      randomly received low-dose streptozotocin (STZ) to induce diabetes and then were 
      randomly assigned to gastric mucosa ablation (GMA, n = 10), sleeve gastrectomy 
      (SG, n = 8), and sham (n = 8) groups. The remaining normal fatty rats were 
      assigned to the non-diabetic gastric mucosa ablation (nGMA, n = 8) group. In the 
      GMA groups, the gastric mucosa was thermally ablated using electrocautery. Rats 
      were followed for 8 weeks postoperatively. Preoperative oral glucose tolerance 
      test (OGTT), insulin tolerance test (ITT), and mixed meal tolerance test (MMTT) 
      were repeated at designated time points postoperatively. Changes in body weight, 
      food intake, and fasting blood glucose were also recorded. RESULTS: Fasting 
      ghrelin concentration and area under curve (AUC) decreased significantly (P < 
      .05) in the GMA groups and the SG group after surgery. Gastrin concentration 
      remained unchanged in SG but decreased significantly in the GMA groups after 
      surgery. Significantly increased GLP-1 AUC was found in the GMA groups and the SG 
      group postoperatively. The decrease in fasting blood glucose did not differ 
      significantly between the diabetic GMA and SG groups after surgery. Glucose AUC 
      during OGTT in both SG and diabetic GMA groups was decreased significantly from 
      the preoperative level, but the decreased glucose AUC in the SG group was 
      significantly greater (P < .05). The decrease in body weight and food intake in 
      the SG group was significantly greater than in the GMA groups. CONCLUSION: 
      Ablation of most of the gastric mucosa along the greater curvature is effective 
      in weight loss and glycemic control in a rodent model.
CI  - Copyright (c) 2021 American Society for Bariatric Surgery. Published by Elsevier 
      Inc. All rights reserved.
FAU - Dolo, Ponnie Robertlee
AU  - Dolo PR
AD  - Department of General Surgery, The Affiliated Hospital of Xuzhou Medical 
      University, Xuzhou Jiangsu, P. R. China; Institute of Digestive Diseases, Xuzhou 
      Medical University, Xuzhou Jiangsu, P. R. China.
FAU - Yao, Libin
AU  - Yao L
AD  - Department of General Surgery, The Affiliated Hospital of Xuzhou Medical 
      University, Xuzhou Jiangsu, P. R. China; Institute of Digestive Diseases, Xuzhou 
      Medical University, Xuzhou Jiangsu, P. R. China.
FAU - Shao, Yong
AU  - Shao Y
AD  - Department of General Surgery, The Affiliated Hospital of Xuzhou Medical 
      University, Xuzhou Jiangsu, P. R. China; Institute of Digestive Diseases, Xuzhou 
      Medical University, Xuzhou Jiangsu, P. R. China.
FAU - Widjaja, Jason
AU  - Widjaja J
AD  - Department of General Surgery, The Affiliated Hospital of Xuzhou Medical 
      University, Xuzhou Jiangsu, P. R. China; Institute of Digestive Diseases, Xuzhou 
      Medical University, Xuzhou Jiangsu, P. R. China.
FAU - Li, Chao
AU  - Li C
AD  - Department of General Surgery, The Affiliated Hospital of Xuzhou Medical 
      University, Xuzhou Jiangsu, P. R. China; Institute of Digestive Diseases, Xuzhou 
      Medical University, Xuzhou Jiangsu, P. R. China.
FAU - Zhu, Xiaocheng
AU  - Zhu X
AD  - Department of General Surgery, The Affiliated Hospital of Xuzhou Medical 
      University, Xuzhou Jiangsu, P. R. China; Institute of Digestive Diseases, Xuzhou 
      Medical University, Xuzhou Jiangsu, P. R. China. Electronic address: 
      zhuxccf@163.com.
LA  - eng
PT  - Journal Article
DEP - 20210808
PL  - United States
TA  - Surg Obes Relat Dis
JT  - Surgery for obesity and related diseases : official journal of the American 
      Society for Bariatric Surgery
JID - 101233161
RN  - 0 (Blood Glucose)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
CIN - Surg Obes Relat Dis. 2021 Dec;17(12):1994-1995. PMID: 34561170
MH  - Animals
MH  - Blood Glucose
MH  - Body Weight
MH  - *Diabetes Mellitus, Experimental/surgery
MH  - *Diabetes Mellitus, Type 2/surgery
MH  - Gastrectomy
MH  - Gastric Mucosa
MH  - Glucose
MH  - Homeostasis
MH  - Humans
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - GLP-1
OT  - Gastric mucosa
OT  - Gastrin
OT  - Ghrelin
OT  - Hindgut
OT  - Obesity
OT  - Sleeve gastrectomy
OT  - Type 2 diabetes
EDAT- 2021/09/05 06:00
MHDA- 2022/03/29 06:00
CRDT- 2021/09/04 05:39
PHST- 2021/02/05 00:00 [received]
PHST- 2021/07/25 00:00 [revised]
PHST- 2021/07/31 00:00 [accepted]
PHST- 2021/09/05 06:00 [pubmed]
PHST- 2022/03/29 06:00 [medline]
PHST- 2021/09/04 05:39 [entrez]
AID - S1550-7289(21)00388-9 [pii]
AID - 10.1016/j.soard.2021.07.025 [doi]
PST - ppublish
SO  - Surg Obes Relat Dis. 2021 Dec;17(12):1984-1994. doi: 10.1016/j.soard.2021.07.025. 
      Epub 2021 Aug 8.