PMID- 34481351
OWN - NLM
STAT- MEDLINE
DCOM- 20211005
LR  - 20211005
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 225
DP  - 2021 Dec 1
TI  - Chlordane exposure causes developmental delay and metabolic disorders in 
      Drosophila melanogaster.
PG  - 112739
LID - S0147-6513(21)00851-4 [pii]
LID - 10.1016/j.ecoenv.2021.112739 [doi]
AB  - The incidence of metabolic diseases is increasing every year, and several studies 
      have highlighted the activity of persistent organic pollutants (POPs) in causing 
      hyperlipidemia and diabetes, and these compounds are considered to be endocrine 
      disrupting chemicals (EDCs). Chlordane is classified as an endocrine disruptor, 
      but the mechanism of how it functions is still unclear. This study investigates 
      the effects of chlordane exposure on Drosophila larvae. Drosophila was cultured 
      in diet containing 0.01 muM, 0.1 muM, 1 muM, 5 muM, and 10 muM chlordane, and the 
      toxicity of chlordane, the growth and development of Drosophila, the homeostasis 
      of glucose and lipid metabolism and insulin signaling pathway, lipid 
      peroxidation-related indicators and Nrf2 signaling pathway were evaluated. We 
      here found that exposure to high concentrations of chlordane decreased the 
      survival rate of Drosophila and that exposure to low concentrations of chlordane 
      caused disruption of glucose and lipid metabolism, increased insulin secretion 
      and impairment of insulin signaling. Notably, it also led to massive ROS 
      production and lipid peroxidation despite of the activation of Nrf2 signaling 
      pathway, an important pathway for maintaining redox homeostasis. Collectively, 
      chlordane causes lipid peroxidation and disrupts redox homeostasis, which may be 
      a potential mechanism leading to impaired insulin signaling and the metabolism of 
      glucose and lipid, ultimately affects Drosophila development.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Wu, Qifang
AU  - Wu Q
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China.
FAU - Du, Xueting
AU  - Du X
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China.
FAU - Feng, Xucong
AU  - Feng X
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China.
FAU - Cheng, Huimin
AU  - Cheng H
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China.
FAU - Chen, Yingjun
AU  - Chen Y
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China.
FAU - Lu, Chenying
AU  - Lu C
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China.
FAU - Wu, Mingjiang
AU  - Wu M
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China.
FAU - Tong, Haibin
AU  - Tong H
AD  - College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, 
      China. Electronic address: tonghaibin@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20210901
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Insulin)
RN  - 12789-03-6 (Chlordan)
SB  - IM
MH  - Animals
MH  - Chlordan
MH  - Drosophila melanogaster
MH  - *Endocrine Disruptors
MH  - Insulin
MH  - *Metabolic Diseases
OTO - NOTNLM
OT  - Chlordane
OT  - Drosophila melanogaster
OT  - Glucose and lipid metabolism
OT  - Oxidative stress
EDAT- 2021/09/05 06:00
MHDA- 2021/10/06 06:00
CRDT- 2021/09/04 20:28
PHST- 2021/07/02 00:00 [received]
PHST- 2021/08/03 00:00 [revised]
PHST- 2021/08/29 00:00 [accepted]
PHST- 2021/09/05 06:00 [pubmed]
PHST- 2021/10/06 06:00 [medline]
PHST- 2021/09/04 20:28 [entrez]
AID - S0147-6513(21)00851-4 [pii]
AID - 10.1016/j.ecoenv.2021.112739 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2021 Dec 1;225:112739. doi: 10.1016/j.ecoenv.2021.112739. 
      Epub 2021 Sep 1.