PMID- 34482580
OWN - NLM
STAT- MEDLINE
DCOM- 20211022
LR  - 20211022
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 75
IP  - 11
DP  - 2021 Nov
TI  - Association of Dietary Inflammatory Index (DII) with disease activity and 
      inflammatory cytokines in the patients with rheumatoid arthritis.
PG  - e14792
LID - 10.1111/ijcp.14792 [doi]
AB  - OBJECTIVES: This study aimed, at first, to assess Dietary Inflammatory Index 
      (DII) in participants with rheumatoid arthritis (RA) and compare them with 
      healthy controls. Then, to evaluate the association of DII with the risk of RA 
      occurrence, the severity of disease, and systemic inflammation. METHODS: This 
      case-control study enrolled 100 newly diagnosed cases with RA and 100 age and 
      sex-matched healthy controls. DII was computed based on the individuals' 
      FFQ-derived dietary data. Serum levels of inflammatory markers, including the 
      high sensitivity C-reactive protein (hs-CRP) and Tumour Necrosis Factor-alpha 
      (TNF-alpha), were measured using the ELISA method; and the severity of the disease 
      was assessed based on the disease activity score 28 (DAS-28). RESULTS: The mean 
      DII score was higher in the RA patients as compared with that in the controls 
      (0.66 +/- 0.23 vs. -0.58 +/- 0.19, P = .002). Patients with the highest DII had 
      significantly higher serum inflammatory (hs-CRP and TNF) and clinical markers 
      (DAS-28 score and the number of tender joints). A significant univariate 
      relationship between DII score and risk of RA incident [6.48 (95% CI: 1.79 to 
      23.44)] disappeared in multivariate analysis. For each 1-unit increase in DII, 
      the DAS-28 score was raised by 1.11 times (P = .001). CONCLUSION: An inflammatory 
      diet may act as a potential risk factor contributing to the development of RA and 
      its severity. Therefore, dietary modification with the goal of reducing the DII 
      score could be a beneficial strategy to improve the clinical outcomes in such 
      patients.
CI  - (c) 2021 John Wiley & Sons Ltd.
FAU - Tandorost, Arash
AU  - Tandorost A
AD  - Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Kheirouri, Sorayya
AU  - Kheirouri S
AD  - Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Moludi, Jalal
AU  - Moludi J
AD  - School of Nutritional Sciences and Food Technology, Kermanshah University of 
      Medical Sciences, Kermanshah, Iran.
FAU - Seyedmardani, Seyedmostafa
AU  - Seyedmardani S
AD  - Department of Rheumatology, School of Medicine, Urmia University of Medical 
      Sciences, Urmia, Iran.
LA  - eng
PT  - Journal Article
DEP - 20210920
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - 0 (Cytokines)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - *Arthritis, Rheumatoid/complications
MH  - C-Reactive Protein
MH  - Case-Control Studies
MH  - *Cytokines
MH  - Diet/adverse effects
MH  - Humans
MH  - Inflammation
OTO - NOTNLM
OT  - dietary inflammatory index
OT  - disease activity
OT  - inflammation
OT  - rheumatoid arthritis
EDAT- 2021/09/06 06:00
MHDA- 2023/02/25 06:00
CRDT- 2021/09/05 21:06
PHST- 2021/09/02 00:00 [revised]
PHST- 2021/07/12 00:00 [received]
PHST- 2021/09/03 00:00 [accepted]
PHST- 2021/09/06 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2021/09/05 21:06 [entrez]
AID - 10.1111/ijcp.14792 [doi]
PST - ppublish
SO  - Int J Clin Pract. 2021 Nov;75(11):e14792. doi: 10.1111/ijcp.14792. Epub 2021 Sep 
      20.