PMID- 34484213 OWN - NLM STAT- MEDLINE DCOM- 20211220 LR - 20211220 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 12 DP - 2021 TI - Association of HLA-DPA1, HLA-DPB1, and HLA-DQB1 Alleles With the Long-Term and Booster Immune Responses of Young Adults Vaccinated Against the Hepatitis B Virus as Neonates. PG - 710414 LID - 10.3389/fimmu.2021.710414 [doi] LID - 710414 AB - The neonatal hepatitis B vaccination (HBVac) was implemented 35 years ago in Taiwan, but many vaccinees exhibit inadequate long-term vaccine-induced seroprotective hepatitis B surface antibody (anti-HBs) levels. We investigated the association of the human leukocyte antigen (HLA) alleles (DPA1, DPB1, DQA1, and DQB1) with the long-term immunological response to the neonatal HBVac and adolescent booster HBVac in a Taiwanese cohort. We divided 281 Han students (median age 22, age range 17-29 years) into the following groups: (1) Group A (n = 61): anti-HBs titer >/= 10 mIU/mL at the beginning of the study; (2) Group B (n = 75): anti-HBs level > 1000 mIU/mL after the first booster; (3) Group C (n = 37): anti-HBs level < 10 mIU/mL after the first booster; and (4) Group D (n = 5): anti-HBs level < 10 mIU/mL after three boosters. DQA1, DQB1, DPA1, and DPB1 typing of the participants was performed using sequence-specific oligonucleotides. Associations of HLA alleles and haplotypes with effects on neonatal HBVac and booster HBVac were examined through logistic regression analysis and Fisher's exact test. A false discovery rate-based measure of significance, the q-value, was used for multiple comparisons, and an association was considered significant if the corresponding q-value was < 0.1. DPA1 alleles were associated with the long-term immunological response to the neonatal HBVac. The estimated odds ratio (OR) of the lack of HBV protective immunity when carrying an additional DPA1*01 and DPA1*02 was 0.36 [95% confidence interval (CI) = 0.17-0.76, p = 0.0076] and 2.39 (95% CI = 1.17-4.87, p = 0.016), respectively. DPB1 and DQB1 alleles were associated with a response to the adolescent booster vaccination. The estimated ORs of being nonresponsive to the first booster when carrying an additional DPB1*05 and DQB1*02 were 2.11 (95% CI = 1.13-3.93, p = 0.019) and 3.73 (95% CI = 1.43-9.71, p = 0.0070), respectively. All DPB1*03 carriers responded to the first booster (p of Fisher's exact test = 0.0045). In our study, we discovered that HLA-DPA1 was primarily associated with the long-term response of primary infantile HBVac, and HLA-DPB1 and HLA-DQB1 exhibited associations with the HBV booster vaccination. CI - Copyright (c) 2021 Wang, Lin, Chang, Yeh, Su, Wu and Su. FAU - Wang, Wen-Chang AU - Wang WC AD - The Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. AD - Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. FAU - Lin, Yu-Shiang AU - Lin YS AD - School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan. AD - Department of Clinical Laboratory, the First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China. FAU - Chang, Yin-Fan AU - Chang YF AD - Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Yeh, Chih-Ching AU - Yeh CC AD - Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. AD - School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan. AD - Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan. AD - Master Program in Applied Epidemiology, College of Public Health, Taipei Medical University, Taipei, Taiwan. FAU - Su, Chien-Tien AU - Su CT AD - School of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan. AD - Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan. FAU - Wu, Jin-Shang AU - Wu JS AD - Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. AD - Department of Family Medicine, National Cheng Kung University Hospital, Douliou Branch, College of Medicine, National Cheng Kung University, Yunlin, Taiwan. AD - Department of Family Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Su, Fu-Hsiung AU - Su FH AD - Department of Family Medicine, Cardinal Tien Hospital, Fu Jen Catholic University, New Taipei City, Taiwan. AD - School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210818 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (HLA-DP alpha-Chains) RN - 0 (HLA-DP beta-Chains) RN - 0 (HLA-DPA1 antigen) RN - 0 (HLA-DPB1 antigen) RN - 0 (HLA-DQ beta-Chains) RN - 0 (HLA-DQB1 antigen) RN - 0 (Hepatitis B Vaccines) SB - IM MH - Adolescent MH - Adult MH - Alleles MH - Case-Control Studies MH - Female MH - HLA-DP alpha-Chains/*genetics MH - HLA-DP beta-Chains/*genetics MH - HLA-DQ beta-Chains/*genetics MH - Haplotypes MH - Hepatitis B Vaccines/*immunology MH - Humans MH - Immunization, Secondary MH - Infant, Newborn MH - Male MH - *Vaccination MH - Young Adult PMC - PMC8416438 OTO - NOTNLM OT - HBV serology OT - booster OT - hepatitis B vaccine OT - human leukocyte antigen OT - immunogenic response COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/09/07 06:00 MHDA- 2021/12/21 06:00 PMCR- 2021/01/01 CRDT- 2021/09/06 05:55 PHST- 2021/05/16 00:00 [received] PHST- 2021/07/19 00:00 [accepted] PHST- 2021/09/06 05:55 [entrez] PHST- 2021/09/07 06:00 [pubmed] PHST- 2021/12/21 06:00 [medline] PHST- 2021/01/01 00:00 [pmc-release] AID - 10.3389/fimmu.2021.710414 [doi] PST - epublish SO - Front Immunol. 2021 Aug 18;12:710414. doi: 10.3389/fimmu.2021.710414. eCollection 2021.