PMID- 34484672
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2045-452X (Print)
IS  - 2045-4538 (Electronic)
IS  - 2045-452X (Linking)
VI  - 10
IP  - 4
DP  - 2021 Aug
TI  - Quercetin fail to protect against the neurotoxic effects of chronic homocysteine 
      administration on motor behavior and oxidative stress in the adult rat's 
      cerebellum.
PG  - 810-816
LID - 10.1093/toxres/tfab065 [doi]
AB  - Homocysteine (Hcy) is an excitatory amino acid that contains thiol group and 
      derives from the methionine metabolism. It increases vulnerability of the 
      neuronal cells to excitotoxic and oxidative damage. This study aimed to 
      investigate the hyperhomocysteinemia (hHcy) effects on rat cerebellum and the 
      possible protective role of quercetin administration in Hcy-treated rats, using 
      behavioral and biochemical analyzes. To this end, the adult male rats were 
      divided randomly into the control group that received vehicle, Hcy group received 
      Hcy (400 mug/kg), Hcy + Que group received Hcy + quercetin (50 mg/kg), quercetin 
      group received quercetin for 14 days. On Day 14 after the final treatment, lipid 
      peroxidation level, the superoxide dismutase (SOD), and glutathione peroxidase 
      (GPx) activities were evaluated in the cerebellum. After completion of treatment, 
      the rat's performance on rotarod and locomotor activity was evaluated. The 
      results showed that Hcy treatment elicited cerebellar lipid peroxidation, 
      impaired locomotor activity and increased latency to fall on the rotarod. 
      Quercetin failed to attenuate significantly motoric impairment, increased 
      significantly the cerebellar lipid peroxidation and GPx activity in the Hcy + Que 
      group. Our results suggest that Hcy induced cerebellar toxicity and quercetin had 
      no significant protective effects against Hcy toxicity in the cerebellum of adult 
      rats.
CI  - (c) The Author(s) 2021. Published by Oxford University Press. All rights reserved. 
      For Permissions, please email: journals.permissions@oup.com.
FAU - Thaimory, Mohaddeseh
AU  - Thaimory M
FAU - Goudarzi, Iran
AU  - Goudarzi I
AUID- ORCID: 0000-0002-6665-3202
FAU - Lashkarbolouki, Taghi
AU  - Lashkarbolouki T
AD  - Faculty of Biology, Damghan University, Cheshme-Ali, Damghan 3671641167, Iran.
FAU - Abrari, Kataneh
AU  - Abrari K
AD  - Faculty of Biology, Damghan University, Cheshme-Ali, Damghan 3671641167, Iran.
LA  - eng
PT  - Journal Article
DEP - 20210712
PL  - England
TA  - Toxicol Res (Camb)
JT  - Toxicology research
JID - 101587950
PMC - PMC8403605
OTO - NOTNLM
OT  - cerebellum
OT  - homocysteine
OT  - oxidative stress
OT  - quercetin
OT  - rat
EDAT- 2021/09/07 06:00
MHDA- 2021/09/07 06:01
PMCR- 2022/07/12
CRDT- 2021/09/06 06:01
PHST- 2021/03/07 00:00 [received]
PHST- 2021/05/14 00:00 [revised]
PHST- 2021/06/20 00:00 [accepted]
PHST- 2021/09/06 06:01 [entrez]
PHST- 2021/09/07 06:00 [pubmed]
PHST- 2021/09/07 06:01 [medline]
PHST- 2022/07/12 00:00 [pmc-release]
AID - tfab065 [pii]
AID - 10.1093/toxres/tfab065 [doi]
PST - epublish
SO  - Toxicol Res (Camb). 2021 Jul 12;10(4):810-816. doi: 10.1093/toxres/tfab065. 
      eCollection 2021 Aug.