PMID- 34484684
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220807
IS  - 2045-452X (Print)
IS  - 2045-4538 (Electronic)
IS  - 2045-452X (Linking)
VI  - 10
IP  - 4
DP  - 2021 Aug
TI  - In vivo effects of exposure to Golden trumpet Handroanthus chrysotrichus in mice.
PG  - 928-936
LID - 10.1093/toxres/tfab076 [doi]
AB  - The Golden trumpet Handroanthus chrysotrichus is a tree that presents beneficial 
      health properties against various diseases. Thus, this study aims to verify the 
      toxicity of H. chrysotrichus bark extract, observing the effects of exposure to 
      this extract in mice. For this, mice were separated in groups: saline (sterile 
      solution .9%); H. chrysotrichus crude extract (HCCE) 10; HCCE 50, and HCCE 
      100 mg. kg(-1) (p.o.). We analyzed HCCE effects on acute (single exposure) and 
      subchronic protocol (14 days exposure). After both exposures, acute, and 
      subchronic, we collected samples from blood, brain, liver, and kidney tissues for 
      biochemical evaluation. In addition, after subchronic exposure, we performed 
      behavioral tests. Acute exposure caused an increase of lipid peroxidation in 
      liver tissue. Moreover, we observed a significant carbonyl increase in liver and 
      brain tissues from HCCE 50 mg. kg(-1). Kidneys presented carbonyl increase in 
      mice treated with the highest concentration. Besides, creatinine increased in the 
      group of the acute exposure at HCCE 100 mg. kg(-1). Total leukocyte count 
      decreased in all concentrations tested. Sub-chronic exposure at HCCE 100 mg. 
      kg(-1) caused a decrease in the number of crossing and an increase in its 
      self-grooming frequency in the open field test. In this exposure, the brain and 
      liver had a significant increase in carbonyl levels in all concentrations. We 
      concluded that H. chrysotrichus cause behavioral and biochemical alterations in 
      mice. HCCE primary targets seem to be the liver, kidneys, and white cells.
CI  - (c) The Author(s) 2021. Published by Oxford University Press. All rights reserved. 
      For permissions, please email: journals.permissions@oup.com.
FAU - Costa, Marcio Tavares
AU  - Costa MT
AUID- ORCID: 0000-0003-4940-3567
AD  - Biochemistry Graduate Program, Federal University of Pampa, Uruguaiana, RS 
      97501-970, Brazil.
FAU - da Silva Goulart, Aline
AU  - da Silva Goulart A
AD  - Biochemistry Graduate Program, Federal University of Pampa, Uruguaiana, RS 
      97501-970, Brazil.
FAU - Rocha, Kellen Mariane Athaide
AU  - Rocha KMA
AD  - Biochemistry Graduate Program, Federal University of Pampa, Uruguaiana, RS 
      97501-970, Brazil.
FAU - Salgueiro, Andreia Caroline Fernandes
AU  - Salgueiro ACF
AUID- ORCID: 0000-0003-4770-2379
AD  - Collaborating Professor of the Science Education, Life Chemistry and Health 
      Graduate Program, Federal University of Pampa, Uruguaiana, RS 97501-970, Brazil.
FAU - da Silva, Morgana Duarte
AU  - da Silva MD
AD  - Department of Physiological Sciences, Federal University of Santa Catarina, 
      Florianopolis, SC 88040-900, Brazil.
FAU - Puntel, Robson Luiz
AU  - Puntel RL
AD  - Biochemistry Graduate Program, Federal University of Pampa, Uruguaiana, RS 
      97501-970, Brazil.
FAU - Folmer, Vanderlei
AU  - Folmer V
AUID- ORCID: 0000-0001-6940-9080
AD  - Biochemistry Graduate Program, Federal University of Pampa, Uruguaiana, RS 
      97501-970, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20210806
PL  - England
TA  - Toxicol Res (Camb)
JT  - Toxicology research
JID - 101587950
PMC - PMC8403612
OTO - NOTNLM
OT  - Tabebuia
OT  - ethnology
OT  - oxidative stress
OT  - pharmacology
OT  - toxicology
EDAT- 2021/09/07 06:00
MHDA- 2021/09/07 06:01
PMCR- 2022/08/06
CRDT- 2021/09/06 06:01
PHST- 2021/03/16 00:00 [received]
PHST- 2021/07/09 00:00 [revised]
PHST- 2021/07/19 00:00 [accepted]
PHST- 2021/09/06 06:01 [entrez]
PHST- 2021/09/07 06:00 [pubmed]
PHST- 2021/09/07 06:01 [medline]
PHST- 2022/08/06 00:00 [pmc-release]
AID - tfab076 [pii]
AID - 10.1093/toxres/tfab076 [doi]
PST - epublish
SO  - Toxicol Res (Camb). 2021 Aug 6;10(4):928-936. doi: 10.1093/toxres/tfab076. 
      eCollection 2021 Aug.