PMID- 34486792
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220401
IS  - 1552-4981 (Electronic)
IS  - 1552-4973 (Linking)
VI  - 110
IP  - 3
DP  - 2022 Mar
TI  - The preparation and study on properties of calcium sulfate bone cement combined 
      tuning silk fibroin nanofibers and vancomycin-loaded silk fibroin microspheres.
PG  - 564-572
LID - 10.1002/jbm.b.34935 [doi]
AB  - In this study, a bioactive composite material based on calcium sulfate 
      hemihydrate (CSH) bone cement was studied, which use calcium sulfate dihydrate 
      (CSD) as coagulant and silk fibroin nanofibers (SFF) solution as the curing 
      liquid, further loaded vancomycin silk fibroin microspheres (SFM/VCM). The drug 
      release effect of bone cements caused by tuning weight content of SFM/VCM (0.5, 
      1, 2%) and the concentration of silk fibroin solution (SFS) (20, 60, 100 mg/mL) 
      used for preparation of SFM was studied in this article. Scanning electron 
      microscope (SEM) demonstrated that the average diameter of microspheres gradually 
      increased and the setting time was prolonged with the concentration of SFS 
      increasing. X-ray diffraction (XRD) and Fourier transform infrared (FTIR) were 
      used to analyze the composition of composite materials. The result of compressive 
      strength revealed that the composites contained 0.5% SFM/VCM showed better 
      mechanical performance independent on the concentration of microspheres and the 
      cumulative drug release percentage of all composites were less than 55% after 
      4 weeks. The drug-loading bone cement possesses not only injectability but also 
      sustained release capability which has a promising prospect in the field of bone 
      substitute material.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Lian, Xiaojie
AU  - Lian X
AD  - Department of Biomedical Engineering, Research Center for Nano-Biomaterials & 
      Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of 
      Technology, Taiyuan, China.
AD  - Shanxi Key Laboratory of Material Strength & Structural Impact, Institute of 
      Biomedical Engineering, Taiyuan University of Technology, Taiyuan, China.
FAU - Xu, Rui
AU  - Xu R
AD  - Department of Biomedical Engineering, Research Center for Nano-Biomaterials & 
      Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of 
      Technology, Taiyuan, China.
FAU - Liu, Shichao
AU  - Liu S
AD  - Department of Biomedical Engineering, Research Center for Nano-Biomaterials & 
      Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of 
      Technology, Taiyuan, China.
FAU - Wang, Zechuan
AU  - Wang Z
AD  - Department of Biomedical Engineering, Research Center for Nano-Biomaterials & 
      Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of 
      Technology, Taiyuan, China.
FAU - Niu, Baolong
AU  - Niu B
AUID- ORCID: 0000-0002-6171-1565
AD  - College of Materials Science and Engineering, Taiyuan University of Technology, 
      Taiyuan, China.
FAU - Huang, Di
AU  - Huang D
AD  - Department of Biomedical Engineering, Research Center for Nano-Biomaterials & 
      Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of 
      Technology, Taiyuan, China.
AD  - Shanxi Key Laboratory of Material Strength & Structural Impact, Institute of 
      Biomedical Engineering, Taiyuan University of Technology, Taiyuan, China.
FAU - Wei, Yan
AU  - Wei Y
AD  - Department of Biomedical Engineering, Research Center for Nano-Biomaterials & 
      Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of 
      Technology, Taiyuan, China.
AD  - Shanxi Key Laboratory of Material Strength & Structural Impact, Institute of 
      Biomedical Engineering, Taiyuan University of Technology, Taiyuan, China.
FAU - Zhao, Liqin
AU  - Zhao L
AD  - Department of Biomedical Engineering, Research Center for Nano-Biomaterials & 
      Regenerative Medicine, College of Biomedical Engineering, Taiyuan University of 
      Technology, Taiyuan, China.
AD  - Shanxi Key Laboratory of Material Strength & Structural Impact, Institute of 
      Biomedical Engineering, Taiyuan University of Technology, Taiyuan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210906
PL  - United States
TA  - J Biomed Mater Res B Appl Biomater
JT  - Journal of biomedical materials research. Part B, Applied biomaterials
JID - 101234238
RN  - 0 (Bone Cements)
RN  - 0 (Silk)
RN  - 6Q205EH1VU (Vancomycin)
RN  - 9007-76-5 (Fibroins)
RN  - WAT0DDB505 (Calcium Sulfate)
SB  - IM
MH  - Bone Cements
MH  - Calcium Sulfate/pharmacology
MH  - *Fibroins
MH  - Microspheres
MH  - *Nanofibers
MH  - Silk
MH  - Vancomycin/pharmacology
OTO - NOTNLM
OT  - bone cement
OT  - calcium sulfate hemihydrate
OT  - silk fibroin microspheres
OT  - silk fibroin nanofibers
OT  - vancomycin
EDAT- 2021/09/07 06:00
MHDA- 2022/04/01 06:00
CRDT- 2021/09/06 09:49
PHST- 2021/06/11 00:00 [revised]
PHST- 2020/11/15 00:00 [received]
PHST- 2021/08/22 00:00 [accepted]
PHST- 2021/09/07 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2021/09/06 09:49 [entrez]
AID - 10.1002/jbm.b.34935 [doi]
PST - ppublish
SO  - J Biomed Mater Res B Appl Biomater. 2022 Mar;110(3):564-572. doi: 
      10.1002/jbm.b.34935. Epub 2021 Sep 6.