PMID- 34488398
OWN - NLM
STAT- MEDLINE
DCOM- 20210908
LR  - 20210908
IS  - 2224-5839 (Electronic)
IS  - 2224-5820 (Linking)
VI  - 10
IP  - 8
DP  - 2021 Aug
TI  - Long-term follow-up of 46 cases of primary fallopian tube carcinoma: a single 
      institute study.
PG  - 9122-9135
LID - 10.21037/apm-21-2083 [doi]
AB  - BACKGROUND: Primary fallopian tube carcinoma (PFTC) is a rare malignancy. In 
      recent years the incidence of PFTC has been rising. This study retrospectively 
      analyzed 46 cases of PFTC to identify prognostic factors that may impact the 
      survival of patients with PFTC and explored the clinical characteristics. 
      METHODS: The clinical data of patients who had undergone surgery and adjuvant 
      chemotherapy in Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University from 1995 to 2015 were retrospectively analyzed. We analyzed clinical 
      data. Cox proportional hazards model was used for univariate and multivariate 
      survival analysis. RESULTS: The level of CA125 increased in almost all patients 
      with advanced-stage (stage III-IV) carcinoma and about half the patients with 
      early stage (stage I-II) carcinoma. On ultrasound examination, 41 cases had 
      pelvic mass, and five cases had intrauterine space-occupying lesion. Nine 
      patients underwent curettage (19.6%). By the International Federation of 
      Gynecology and Obstetricians (FIGO) staging system, the distribution of patients 
      was 18 at stage I, 16 at stage II, 10 at stage III, and 2 at stage IV. The 
      mainstay of treatment was surgical cytoreduction and platinum-based chemotherapy. 
      Four patients had residual tumors diameter </=1 cm (R1), 10 had residual tumors 
      diameter >1 cm, and 32 had no macroscopic residual tumor (R0). Forty patients 
      received postoperative intravenous (IV) chemotherapy. The five-year overall 
      survival (OS) was 94.7% in stage I, 80.0% in stage II, 44.4% in stage III, and 0% 
      in stage IV. Univariate and multivariate analysis revealed that residual tumor 
      was independent prognostic variable for OS. Univariate and multivariate analysis 
      revealed that ascites tumor cells and residual tumor were independent prognostic 
      variables for progression free survival (PFS). CONCLUSIONS: Any postmenopausal 
      women with vaginal bleeding, vaginal discharge, or lower abdominal pain should be 
      alert to PFTC. Complete tumor markers and imaging examination should be conducted 
      as soon as possible to improve the early diagnosis rate of the disease. 
      Regardless of whether the operation is a comprehensive staging operation or 
      cytoreductive surgery (CRS), achieving satisfactory R0 can improve OS and PFS. It 
      is important the ascitic fluid is tested for tumor markers in order to predict 
      PFS.
FAU - Li, Shanji
AU  - Li S
AD  - Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, 
      Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of 
      Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Yu, Minhua
AU  - Yu M
AD  - Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, 
      Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of 
      Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Bai, Wenxin
AU  - Bai W
AD  - Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, 
      Shanghai Jiao Tong University, Shanghai, China; School of Medicine, Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Shi, Jun
AU  - Shi J
AD  - Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, 
      Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of 
      Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Di, Wen
AU  - Di W
AD  - Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, 
      Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of 
      Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 
      University, Shanghai, China; State Key Laboratory of Oncogenes and Related Genes, 
      Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao 
      Tong University, Shanghai, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Palliat Med
JT  - Annals of palliative medicine
JID - 101585484
SB  - IM
MH  - *Carcinoma/pathology
MH  - China
MH  - *Fallopian Tubes/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Primary fallopian tube carcinoma (PFTC)
OT  - follow-up
OT  - overall survival
OT  - prognosis
OT  - progression free survival
EDAT- 2021/09/08 06:00
MHDA- 2021/09/09 06:00
CRDT- 2021/09/07 05:44
PHST- 2021/06/02 00:00 [received]
PHST- 2021/08/12 00:00 [accepted]
PHST- 2021/09/07 05:44 [entrez]
PHST- 2021/09/08 06:00 [pubmed]
PHST- 2021/09/09 06:00 [medline]
AID - 10.21037/apm-21-2083 [doi]
PST - ppublish
SO  - Ann Palliat Med. 2021 Aug;10(8):9122-9135. doi: 10.21037/apm-21-2083.