PMID- 34490156
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210908
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 9
DP  - 2021
TI  - Adverse Events During Supervised Exercise Interventions in Pediatric Oncology-A 
      Nationwide Survey.
PG  - 682496
LID - 10.3389/fped.2021.682496 [doi]
LID - 682496
AB  - Objectives: Exercise interventions during and after treatment for pediatric 
      cancer are associated with beneficial physical, psychological, and social 
      effects. However, valid data about adverse events (AEs) of such interventions 
      have rarely been evaluated. This retrospective study evaluates AEs that occurred 
      during supervised oncological exercise programs for pediatric cancer patients and 
      survivors. Methods: This Germany-wide study used a self-administered online 
      survey focusing on general program characteristics and AEs retrospectively for 
      2019. The questionnaire included (a) basic data on the offered exercise program, 
      (b) AEs with consequences (Grade 2-5) that occurred in 2019 during an exercise 
      intervention, (c) number of Grade 1 AEs, (d) safety procedures as part of the 
      exercise programs, and (e) possibility to give feedback and describe experience 
      with AEs in free text. Results: Out of 26 eligible exercise programs, response 
      rate of program leaders was 92.3% (n = 24). Representatives working for 
      Universities (n = 6), rehabilitation clinics (n = 3), acute cancer clinics (n = 
      12), and activity camps (n = 3) participated. In total, 35,110 exercise 
      interventions with varying duration were recorded for 2019. Six AEs with 
      consequences (Grade 2-3) occurred during exercise interventions after cancer 
      treatment resulting in an incidence of 17 per 100,000 exercise interventions 
      (0.017%). No life-threatening consequences or death were reported and no serious 
      AE occurred during acute cancer treatment. Grade 1 AE occurred with a frequency 
      of 983, corresponding to an incidence of 2,800 per 100,000 interventions (2.8%). 
      Most frequent Grade 1 AE were muscle soreness, circulatory problems, and 
      abdominal pain. The most frequent preventive safety procedures at the 
      institutions were regular breaks, consultations with the medical treatment team, 
      and material selection with low injury potential. Conclusions: Supervised 
      exercise interventions for pediatric cancer patients and survivors seem to be 
      safe and AEs with consequences comparatively rare when compared to general 
      childhood population data. Occurrence of grade 1 AEs was common, however, 
      causality was probably not evident between AEs and the exercise intervention. 
      Future research should standardize assessment of AEs in clinical practice and 
      research, and prospectively register and evaluate AEs that occur in the context 
      of exercise interventions in pediatric cancer patients and survivors.
CI  - Copyright (c) 2021 Gauss, Beller, Boos, Daggelmann, Stalf, Wiskemann and Gotte.
FAU - Gauss, Gabriele
AU  - Gauss G
AD  - Department of Pediatric Hematology and Oncology, Pediatrics III, West German 
      Cancer Center, University Hospital Essen, Essen, Germany.
FAU - Beller, Ronja
AU  - Beller R
AD  - Department of Pediatric Hematology and Oncology, Pediatrics III, West German 
      Cancer Center, University Hospital Essen, Essen, Germany.
FAU - Boos, Joachim
AU  - Boos J
AD  - Department of Pediatric Hematology and Oncology, University Children's Hospital 
      Muenster, Munster, Germany.
FAU - Daggelmann, Julia
AU  - Daggelmann J
AD  - Department of Molecular and Cellular Sports Medicine, Institute of Cardiology and 
      Sports Medicine, German Sport University Cologne, Cologne, Germany.
FAU - Stalf, Hannah
AU  - Stalf H
AD  - Division of Pediatric Hematology and Oncology, Hospital for Children and 
      Adolescents, University Hospital Frankfurt, Goethe University, Frankfurt am Main, 
      Germany.
FAU - Wiskemann, Joachim
AU  - Wiskemann J
AD  - Working Group Exercise Oncology Division of Medical Oncology, University Clinic 
      Heidelberg and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
FAU - Gotte, Miriam
AU  - Gotte M
AD  - Department of Pediatric Hematology and Oncology, Pediatrics III, West German 
      Cancer Center, University Hospital Essen, Essen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20210819
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC8417361
OTO - NOTNLM
OT  - adverse events
OT  - childhood cancer
OT  - oncological exercise therapy
OT  - physical activity
OT  - questionnaire
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/09/08 06:00
MHDA- 2021/09/08 06:01
PMCR- 2021/08/19
CRDT- 2021/09/07 07:45
PHST- 2021/03/18 00:00 [received]
PHST- 2021/05/18 00:00 [accepted]
PHST- 2021/09/07 07:45 [entrez]
PHST- 2021/09/08 06:00 [pubmed]
PHST- 2021/09/08 06:01 [medline]
PHST- 2021/08/19 00:00 [pmc-release]
AID - 10.3389/fped.2021.682496 [doi]
PST - epublish
SO  - Front Pediatr. 2021 Aug 19;9:682496. doi: 10.3389/fped.2021.682496. eCollection 
      2021.