PMID- 34490286
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210908
IS  - 2296-858X (Print)
IS  - 2296-858X (Electronic)
IS  - 2296-858X (Linking)
VI  - 8
DP  - 2021
TI  - The Role of Atopy in COPD and Asthma.
PG  - 674742
LID - 10.3389/fmed.2021.674742 [doi]
LID - 674742
AB  - Common to several allergic diseases is the generation of immunoglobulin E (IgE) 
      by plasma cells, when exposed to an innocuous antigen. Asthma and chronic 
      obstructive pulmonary disease (COPD) are two prevalent chronic airway 
      inflammatory diseases. Asthma is mediated in some patients through eosinophilic 
      inflammatory mechanisms that include allergic sensitization and Th2-mediated 
      immune airway response. COPD, on the other hand is mainly considered a 
      Th1-mediated inflammatory process with neutrophilic predominance or a non-Th2 
      inflammation, occasionally associated with the presence of airway bacteria or 
      viruses. IgE production appears to play an important role in the development of 
      both COPD and asthma, as it has been associated to respiratory symptoms, lung 
      function, bacterial and viral infections, airway remodeling and bronchial 
      hyperreactivity in both diseases. The aim of this review is to summarize all 
      current data concerning the role of specific and total IgE in COPD and asthma and 
      to highlight similarities and differences in view of possible therapeutic 
      interventions.
CI  - Copyright (c) 2021 Karakioulaki, Papakonstantinou, Goulas and Stolz.
FAU - Karakioulaki, Meropi
AU  - Karakioulaki M
AD  - Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital 
      of Basel, Basel, Switzerland.
AD  - First Laboratory of Pharmacology, Department of Medicine, School of Health 
      Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
FAU - Papakonstantinou, Eleni
AU  - Papakonstantinou E
AD  - Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital 
      of Basel, Basel, Switzerland.
AD  - First Laboratory of Pharmacology, Department of Medicine, School of Health 
      Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
FAU - Goulas, Antonios
AU  - Goulas A
AD  - First Laboratory of Pharmacology, Department of Medicine, School of Health 
      Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
FAU - Stolz, Daiana
AU  - Stolz D
AD  - Clinic of Respiratory Medicine and Pulmonary Cell Research, University Hospital 
      of Basel, Basel, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210818
PL  - Switzerland
TA  - Front Med (Lausanne)
JT  - Frontiers in medicine
JID - 101648047
PMC - PMC8418108
OTO - NOTNLM
OT  - COPD
OT  - IgE
OT  - allergy
OT  - asthma
OT  - atopy
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/09/08 06:00
MHDA- 2021/09/08 06:01
PMCR- 2021/08/18
CRDT- 2021/09/07 07:46
PHST- 2021/03/01 00:00 [received]
PHST- 2021/07/26 00:00 [accepted]
PHST- 2021/09/07 07:46 [entrez]
PHST- 2021/09/08 06:00 [pubmed]
PHST- 2021/09/08 06:01 [medline]
PHST- 2021/08/18 00:00 [pmc-release]
AID - 10.3389/fmed.2021.674742 [doi]
PST - epublish
SO  - Front Med (Lausanne). 2021 Aug 18;8:674742. doi: 10.3389/fmed.2021.674742. 
      eCollection 2021.