PMID- 34491229
OWN - NLM
STAT- MEDLINE
DCOM- 20220114
LR  - 20221207
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 13
IP  - 17
DP  - 2021 Sep 6
TI  - Identification and epidemiological evaluation of gastric cancer risk factors: 
      based on a field synopsis and meta-analysis in Chinese population.
PG  - 21451-21469
LID - 10.18632/aging.203484 [doi]
AB  - To summarize and assess the credibility and strength of non-genetic factors and 
      genetic variation on gastric cancer risk, we performed a field synopsis and 
      meta-analysis to identify the risk of gastric cancer in Chinese population. 
      Cumulative evidence was graded according to the Venice criteria, and attributable 
      risk percentage (ARP) and population attributable risk percentage (PARP) were 
      used to evaluate the epidemiological effect. A total of 956 studies included 
      non-genetic (404 studies) and genetic factors (552 studies) were quantified, and 
      data on 1161 single nucleotide polymorphisms (SNPs) were available. We identified 
      14 non-genetic factors were significantly associated with gastric cancer risk. 
      For the analysis of time trends, H. pylori infection rate in gastric cancer and 
      population showed a downward trend. Meanwhile 22 variants were identified 
      significantly associated with gastric cancer: 3 (PLCE1 rs2274223, PSCA rs2976392, 
      MUC1 rs4072037) were high and 19 SNPs were intermediate level of summary 
      evidence, respectively. For non-genetic factors, the top three for ARP were 
      54.75% (pickled food), 65.87% (stomach disease), and 49.75% (smoked and frying). 
      For PARP were 34.22% (pickled food), 34.24% (edible hot food) and 23.66%(H. 
      pylori infection). On the basis of ARP and PARP associated with SNPs of gastric 
      cancer, the top three for ARP were 53.91% (NAT2, rs1799929),53.05% (NAT2 
      phenotype), and 42.85% (IL-10, rs1800896). For PARP (Chinese Han in Beijing) were 
      36.96% (VDR, rs731236), 25.58% (TGFBR2, rs3773651) and 20.56% (MUC1, rs4072037). 
      Our study identified non-genetic risk factors and high-quality biomarkers of 
      gastric cancer susceptibility and their contribution to gastric cancer.
FAU - Duan, Fujiao
AU  - Duan F
AD  - College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.
AD  - Key Laboratory of Tumor Epidemiology of Henan Province, Zhengzhou, Henan 
      Province, China.
AD  - Medical Research Office, Affiliated Cancer Hospital of Zhengzhou University, 
      Zhengzhou, Henan Province, China.
FAU - Song, Chunhua
AU  - Song C
AD  - College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.
AD  - Key Laboratory of Tumor Epidemiology of Henan Province, Zhengzhou, Henan 
      Province, China.
FAU - Shi, Jiachen
AU  - Shi J
AD  - Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou 
      University,Zhengzhou, Henan Province, China.
FAU - Wang, Peng
AU  - Wang P
AD  - College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.
AD  - Key Laboratory of Tumor Epidemiology of Henan Province, Zhengzhou, Henan 
      Province, China.
FAU - Ye, Hua
AU  - Ye H
AD  - College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.
AD  - Key Laboratory of Tumor Epidemiology of Henan Province, Zhengzhou, Henan 
      Province, China.
FAU - Dai, Liping
AU  - Dai L
AD  - College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.
AD  - Key Laboratory of Tumor Epidemiology of Henan Province, Zhengzhou, Henan 
      Province, China.
FAU - Zhang, Jianying
AU  - Zhang J
AD  - College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.
AD  - Key Laboratory of Tumor Epidemiology of Henan Province, Zhengzhou, Henan 
      Province, China.
FAU - Wang, Kaijuan
AU  - Wang K
AD  - College of Public Health, Zhengzhou University, Zhengzhou, Henan Province, China.
AD  - Key Laboratory of Tumor Epidemiology of Henan Province, Zhengzhou, Henan 
      Province, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20210906
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Asian People
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - *Genetic Variation
MH  - Genome-Wide Association Study
MH  - Humans
MH  - Neoplasm Proteins/*genetics/metabolism
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - Stomach Neoplasms/*genetics/metabolism
PMC - PMC8457565
OTO - NOTNLM
OT  - field synopsis
OT  - gastric cancer
OT  - genetic variants
OT  - risk factors
OT  - susceptibility
COIS- CONFLICTS OF INTEREST: The authors declare that they have no conflicts of 
      interest.
EDAT- 2021/09/08 06:00
MHDA- 2022/01/15 06:00
PMCR- 2021/09/15
CRDT- 2021/09/07 12:23
PHST- 2021/01/10 00:00 [received]
PHST- 2021/08/11 00:00 [accepted]
PHST- 2021/09/08 06:00 [pubmed]
PHST- 2022/01/15 06:00 [medline]
PHST- 2021/09/07 12:23 [entrez]
PHST- 2021/09/15 00:00 [pmc-release]
AID - 203484 [pii]
AID - 10.18632/aging.203484 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2021 Sep 6;13(17):21451-21469. doi: 10.18632/aging.203484. 
      Epub 2021 Sep 6.