PMID- 34491392 OWN - NLM STAT- MEDLINE DCOM- 20220406 LR - 20221207 IS - 1615-2573 (Electronic) IS - 0910-8327 (Linking) VI - 37 IP - 3 DP - 2022 Mar TI - Validation of the correlation between angiosome-based target arterial path, mid-term limb-based patency, and the global limb anatomical staging system. PG - 496-504 LID - 10.1007/s00380-021-01937-5 [doi] AB - This study aimed to validate the correlation between the Global Limb Anatomical Staging System (GLASS) and limb-based patency (LBP) and angiosome-based target arterial path (TAP) and to detect the predictors of LBP loss. After the publication of the Global Vascular Guidelines in 2019, the evaluation of GLASS and identification of TAP have been recommended. However, there are few reports regarding GLASS. Eighty-three patients with chronic limb-threatening ischemia (CLTI) and tissue loss from 2016 to 2020 were evaluated. The correlation between GLASS and LBP and successful revascularization of angiosome-based TAP was analyzed. We also investigated the predictors of LBP loss. The number of patients in each GLASS stage was as follows: GLASS I, 6 patients; GLASS II, 15 patients; GLASS III, 62 patients. At 6 months, the Kaplan-Meier estimate of LBP was 66.7% in GLASS I, 41.6% in GLASS II, and 16.4% in GLASS III, respectively (p = 0.034). The rate of successful revascularization of angiosome-based TAP was 100% in GLASS I, 86.7% in GLASS II, and 46.8% in GLASS III, respectively (p = 0.002). Multivariate analysis showed that the Wound, Ischemia, and foot Infection (WIfI) stage [hazard ratio (HR) 1.58; 95% confidence interval (CI) 1.07-2.33; p = 0.021] and GLASS infrapopliteal (IP) grade (HR 1.96; 95% CI 1.31-2.95; p = 0.001) were the independent predictors of LBP loss. The GLASS stage was significantly correlated with successful revascularization of angiosome-based TAP and mid-term LBP. The WIfI stage and GLASS IP grade were the independent predictors of loss of LBP. CI - (c) 2021. Springer Japan KK, part of Springer Nature. FAU - Yamada, Takehiro AU - Yamada T AUID- ORCID: 0000-0001-9711-1054 AD - Division of Cardiology, Cardiovascular Center, Kizawa Memorial Hospital, 590 Shimokobi, Kobi, Gifu, Minokamo, 5058503, Japan. t.yamada1104@gmail.com. FAU - Shibahara, Taro AU - Shibahara T AD - Division of Cardiology, Cardiovascular Center, Kizawa Memorial Hospital, 590 Shimokobi, Kobi, Gifu, Minokamo, 5058503, Japan. FAU - Nagase, Masaru AU - Nagase M FAU - Ono, Daiju AU - Ono D AD - Division of Cardiology, Cardiovascular Center, Kizawa Memorial Hospital, 590 Shimokobi, Kobi, Gifu, Minokamo, 5058503, Japan. FAU - Tanabe, Gen AU - Tanabe G AD - Division of Cardiology, Cardiovascular Center, Kizawa Memorial Hospital, 590 Shimokobi, Kobi, Gifu, Minokamo, 5058503, Japan. FAU - Suzuki, Keita AU - Suzuki K AD - Division of Cardiology, Cardiovascular Center, Kizawa Memorial Hospital, 590 Shimokobi, Kobi, Gifu, Minokamo, 5058503, Japan. FAU - Yamaura, Makoto AU - Yamaura M AD - Division of Cardiology, Cardiovascular Center, Kizawa Memorial Hospital, 590 Shimokobi, Kobi, Gifu, Minokamo, 5058503, Japan. AD - Division of Molecular Pathology, Shinshu University of Medicine, Matsumoto, Japan. FAU - Ido, Takahisa AU - Ido T AD - Division of Cardiology, Cardiovascular Center, Kizawa Memorial Hospital, 590 Shimokobi, Kobi, Gifu, Minokamo, 5058503, Japan. AD - Division of Cardiology, Gifu University of Medicine, Gifu, Japan. FAU - Nakashima, Takashi AU - Nakashima T AD - Division of Cardiology, Cardiovascular Center, Kizawa Memorial Hospital, 590 Shimokobi, Kobi, Gifu, Minokamo, 5058503, Japan. AD - Division of Cardiology, Gifu University of Medicine, Gifu, Japan. FAU - Takahashi, Shigekiyo AU - Takahashi S AD - Division of Cardiology, Cardiovascular Center, Kizawa Memorial Hospital, 590 Shimokobi, Kobi, Gifu, Minokamo, 5058503, Japan. AD - Division of Cardiology, Gifu University of Medicine, Gifu, Japan. FAU - Aoyama, Takuma AU - Aoyama T AD - Division of Cardiology, Cardiovascular Center, Kizawa Memorial Hospital, 590 Shimokobi, Kobi, Gifu, Minokamo, 5058503, Japan. AD - Division of Molecular Pathology, Shinshu University of Medicine, Matsumoto, Japan. AD - Division of Cardiology, Gifu University of Medicine, Gifu, Japan. LA - eng PT - Journal Article DEP - 20210907 PL - Japan TA - Heart Vessels JT - Heart and vessels JID - 8511258 SB - IM MH - Amputation, Surgical MH - Chronic Disease MH - *Endovascular Procedures MH - Humans MH - Ischemia MH - Limb Salvage MH - *Peripheral Arterial Disease MH - Retrospective Studies MH - Risk Factors MH - Time Factors MH - Treatment Outcome OTO - NOTNLM OT - Chronic limb-threatening ischemia OT - Endovascular therapy OT - Global limb anatomical staging system OT - Peripheral artery disease OT - Target arterial path EDAT- 2021/09/08 06:00 MHDA- 2022/04/07 06:00 CRDT- 2021/09/07 12:33 PHST- 2021/05/20 00:00 [received] PHST- 2021/09/03 00:00 [accepted] PHST- 2021/09/08 06:00 [pubmed] PHST- 2022/04/07 06:00 [medline] PHST- 2021/09/07 12:33 [entrez] AID - 10.1007/s00380-021-01937-5 [pii] AID - 10.1007/s00380-021-01937-5 [doi] PST - ppublish SO - Heart Vessels. 2022 Mar;37(3):496-504. doi: 10.1007/s00380-021-01937-5. Epub 2021 Sep 7.