PMID- 34491621
OWN - NLM
STAT- MEDLINE
DCOM- 20220316
LR  - 20220316
IS  - 1742-7843 (Electronic)
IS  - 1742-7835 (Linking)
VI  - 130
IP  - 1
DP  - 2022 Jan
TI  - Multiple regulation and targeting effects of borneol in the neurovascular unit in 
      neurodegenerative diseases.
PG  - 5-19
LID - 10.1111/bcpt.13656 [doi]
AB  - Efficient delivery of brain-targeted drugs is highly important for the success of 
      therapies in neurodegenerative diseases. Borneol has several biological 
      activities, such as anti-inflammatory and cell penetration enhancing effect, and 
      can regulate processes in the neurovascular unit (NVU), such as protein toxic 
      stress, autophagosome/lysosomal system, oxidative stress, programmed cell death 
      and neuroinflammation. However, the influence of borneol on NVU in 
      neurodegenerative diseases has not been fully explained. This study searched the 
      keywords 'borneol', 'neurovascular unit', 'endothelial cell', 'astrocyte', 
      'neuron', 'blood-brain barrier', 'neurodegenerative diseases' and 'brain disease' 
      in PubMed, BioMed Central, China National Knowledge Infrastructure (CNKI) and 
      Bing search engines to explore the influence of borneol on NVU. In addition to 
      the principle and mechanism of penetration of borneol in the brain, this study 
      also showed its multiple regulation effects on NVU. Borneol was able to penetrate 
      the blood-brain barrier (BBB), affecting the signal transmission between BBB and 
      the microenvironment of the brain, downregulating the expression of inflammatory 
      and oxidative stress proteins in NVU, especially in microglia and astrocytes. In 
      summary, borneol is a potential drug delivery agent for drugs against 
      neurodegenerative diseases.
CI  - (c) 2021 Nordic Association for the Publication of BCPT (former Nordic 
      Pharmacological Society). Published by John Wiley & Sons Ltd.
FAU - Chen, Nian
AU  - Chen N
AUID- ORCID: 0000-0002-5835-232X
AD  - State Key Laboratory of Southwestern Chinese Medicine Resources, School of 
      Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
FAU - Wen, Jing
AU  - Wen J
AD  - Department of Pharmacology, North Sichuan Medical College, Nanchong, China.
FAU - Wang, Zhilei
AU  - Wang Z
AUID- ORCID: 0000-0001-5518-954X
AD  - TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of 
      Chengdu University of Traditional Chinese Medicine, Chengdu, China.
FAU - Wang, Jian
AU  - Wang J
AD  - State Key Laboratory of Southwestern Chinese Medicine Resources, School of 
      Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
LA  - eng
GR  - CBY19-QD07/Doctor Initiation Fund of North Sichuan Medical College/
GR  - 81873023/National Natural Science Foundation of China/
PT  - Journal Article
PT  - Systematic Review
DEP - 20211124
PL  - England
TA  - Basic Clin Pharmacol Toxicol
JT  - Basic & clinical pharmacology & toxicology
JID - 101208422
RN  - 0 (Camphanes)
RN  - L88RA8N5EG (isoborneol)
SB  - IM
MH  - Animals
MH  - Astrocytes/metabolism
MH  - Blood-Brain Barrier/metabolism
MH  - Brain/metabolism/physiopathology
MH  - Camphanes/*administration & dosage/pharmacokinetics/pharmacology
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Microglia/metabolism
MH  - Neurodegenerative Diseases/*drug therapy
MH  - Tissue Distribution
OTO - NOTNLM
OT  - borneol
OT  - inflammatory
OT  - neurodegenerative diseases
OT  - neurovascular unit
OT  - targeted delivery
EDAT- 2021/09/08 06:00
MHDA- 2022/03/17 06:00
CRDT- 2021/09/07 12:51
PHST- 2021/09/03 00:00 [revised]
PHST- 2021/06/19 00:00 [received]
PHST- 2021/09/06 00:00 [accepted]
PHST- 2021/09/08 06:00 [pubmed]
PHST- 2022/03/17 06:00 [medline]
PHST- 2021/09/07 12:51 [entrez]
AID - 10.1111/bcpt.13656 [doi]
PST - ppublish
SO  - Basic Clin Pharmacol Toxicol. 2022 Jan;130(1):5-19. doi: 10.1111/bcpt.13656. Epub 
      2021 Nov 24.