PMID- 34493614
OWN - NLM
STAT- MEDLINE
DCOM- 20211029
LR  - 20230923
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Print)
IS  - 0028-3878 (Linking)
VI  - 97
IP  - 17
DP  - 2021 Oct 26
TI  - Association Between Body Mass Index and Disability in Children With 
      Charcot-Marie-Tooth Disease.
PG  - e1727-e1736
LID - 10.1212/WNL.0000000000012725 [doi]
AB  - BACKGROUND AND OBJECTIVES: This study examined the association between body mass 
      index (BMI) and disability in children with Charcot-Marie-Tooth disease (CMT). 
      METHODS: We conducted a cross-sectional analysis of 477 patients with CMT who 
      were 3 to 20 years of age from the Inherited Neuropathy Consortium and 316 age- 
      and sex-matched healthy children from the 1,000 Norms Project. BMI was 
      categorized according to the International Obesity Task Force (IOTF) criteria, 
      and BMI categorization was compared with healthy children. IOTF categories (adult 
      equivalent BMI cut points) were severely underweight (BMI <17 kg/m(2)), 
      underweight (BMI >/=17-<18.5 kg/m(2)), healthy weight (BMI >/=18.5-<25 kg/m(2)), 
      overweight (BMI >/=25-<30 kg/m(2)), and obese (BMI >/=30 kg/m(2)). Scores on the 0 to 
      44-point CMT Pediatric Scale (CMTPedS), a well-validated measure of disability, 
      were examined in relation to BMI. RESULTS: There was a higher proportion of 
      children with CMT categorized as severely underweight (5.7% vs 0.3%), underweight 
      (10.3% vs 5.1%), and obese (7.3% vs 3.8%) (p < 0.05). Fewer children with CMT 
      were categorized as healthy weight (61.8% vs 74.4%) (p < 0.05), and the 
      proportion of overweight (14.9% vs 16.5%) between groups was similar. CMTPedS 
      scores (mean +/- SD) for weight categories were as follows: severely underweight 27 
      +/- 9, underweight 20 +/- 8, healthy weight 17 +/- 9, overweight 17 +/- 9, and obese 22 +/- 
      10. Compared to children with a healthy weight with CMT, being severely 
      underweight was associated with being more disabled (p < 0.001), as was being 
      obese (p = 0.015). DISCUSSION: The proportion of children with CMT who are 
      underweight or obese is higher compared to age- and sex-matched healthy children. 
      In children with CMT, being underweight or obese is associated with greater 
      disability, when compared to children with CMT of healthy weight.
CI  - (c) 2021 American Academy of Neurology.
FAU - Donlevy, Gabrielle A
AU  - Donlevy GA
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY. gabrielle.donlevy@health.nsw.gov.au.
FAU - Garnett, Sarah P
AU  - Garnett SP
AUID- ORCID: 0000-0001-7552-0789
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Cornett, Kayla M D
AU  - Cornett KMD
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - McKay, Marnee J
AU  - McKay MJ
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Baldwin, Jennifer N
AU  - Baldwin JN
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Shy, Rosemary R
AU  - Shy RR
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Yum, Sabrina W
AU  - Yum SW
AUID- ORCID: 0000-0002-5243-5546
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Estilow, Timothy
AU  - Estilow T
AUID- ORCID: 0000-0003-4859-0487
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Moroni, Isabella
AU  - Moroni I
AUID- ORCID: 0000-0002-3322-1681
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Foscan, Maria
AU  - Foscan M
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Pagliano, Emanuela
AU  - Pagliano E
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Pareyson, Davide
AU  - Pareyson D
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Laura, Matilde
AU  - Laura M
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Bhandari, Trupti
AU  - Bhandari T
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Muntoni, Francesco
AU  - Muntoni F
AUID- ORCID: 0000-0002-9102-5232
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Reilly, Mary M
AU  - Reilly MM
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Finkel, Richard S
AU  - Finkel RS
AUID- ORCID: 0000-0002-9351-7054
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Sowden, Janet E
AU  - Sowden JE
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Eichinger, Katy J
AU  - Eichinger KJ
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Herrmann, David N
AU  - Herrmann DN
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Shy, Michael E
AU  - Shy ME
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Burns, Joshua
AU  - Burns J
AUID- ORCID: 0000-0001-7936-623X
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
FAU - Menezes, Manoj P
AU  - Menezes MP
AUID- ORCID: 0000-0003-3160-6112
AD  - From the University of Sydney (G.A.D., S.P.G., M.P.M.), Faculty of Medicine and 
      Health; Children's Hospital at Westmead (G.A.D., S.P.G., K.M.D.C., J.B., M.P.M.); 
      University of Sydney (K.M.D.C., M.J.M., J.B.), School of Health Sciences; Faculty 
      of Health and Medicine (J.N.B.), University of Newcastle, Australia; Departments 
      of Pediatrics (R.R.S.) and Neurology (M.E.S.), Carver College of Medicine, 
      University of Iowa, Iowa City; Division of Neurology (S.W.Y.) and Department of 
      Occupational Therapy (T.E.), Children's Hospital of Philadelphia; Department of 
      Neurology (S.W.Y., T.E.), Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia; Fondazione IRCCS Istituto Neurologico Carlo Besta 
      (I.M., M.F., E.P., D.P.), Milan, Italy; Centre for Neuromuscular Diseases (M.L., 
      M.M.R.), University College London, Queen Square; University College London 
      Institute of Child Health & Great Ormond Street Hospital (T.B., F.M.), London, 
      England; Translational Neurosciences (Pediatrics) (R.S.F.), St. Jude Children's 
      Research Hospital, Memphis, TN; and Department of Neurology (J.E.S., K.J.E., 
      D.N.H.), University of Rochester, NY.
LA  - eng
PT  - Journal Article
DEP - 20210907
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
MH  - Adolescent
MH  - Body Mass Index
MH  - Charcot-Marie-Tooth Disease/*complications
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Disability Evaluation
MH  - Female
MH  - Humans
MH  - Male
MH  - Obesity/*epidemiology
MH  - Thinness/*epidemiology
MH  - Young Adult
PMC - PMC8605613
EDAT- 2021/09/09 06:00
MHDA- 2021/10/30 06:00
PMCR- 2022/10/26
CRDT- 2021/09/08 06:15
PHST- 2021/02/15 00:00 [received]
PHST- 2021/08/16 00:00 [accepted]
PHST- 2021/09/09 06:00 [pubmed]
PHST- 2021/10/30 06:00 [medline]
PHST- 2021/09/08 06:15 [entrez]
PHST- 2022/10/26 00:00 [pmc-release]
AID - WNL.0000000000012725 [pii]
AID - NEUROLOGY2021171185 [pii]
AID - 10.1212/WNL.0000000000012725 [doi]
PST - ppublish
SO  - Neurology. 2021 Oct 26;97(17):e1727-e1736. doi: 10.1212/WNL.0000000000012725. 
      Epub 2021 Sep 7.