PMID- 34494235
OWN - NLM
STAT- MEDLINE
DCOM- 20220311
LR  - 20220311
IS  - 1933-7205 (Electronic)
IS  - 1933-7191 (Linking)
VI  - 29
IP  - 1
DP  - 2022 Jan
TI  - Voluntary Exercise Attenuates Hyperhomocysteinemia, But Does not Protect Against 
      Hyperhomocysteinemia-Induced Testicular and Epididymal Disturbances.
PG  - 277-290
LID - 10.1007/s43032-021-00704-1 [doi]
AB  - The hyperhomocysteinemia (HHcy) is toxic to the cells and associated with several 
      diseases. Clinical studies have shown changes in plasma concentrations of Hcy 
      after physical exercise. This study aimed to assess the effect of HHcy on testis, 
      epididymis and sperm quality and to investigate whether voluntary exercise 
      training protects this system against damage caused by HHcy in Swiss mice. In 
      this study, 48 mice were randomly distributed in the control, HHcy, physical 
      exercise, and HHcy combined with physical exercise groups. HHcy was induced by 
      daily administration of dl-homocysteine thiolactone via gavage throughout the 
      experimental period. Physical exercise was performed through voluntary running on 
      the exercise wheels. The plasma concentrations of homocysteine (Hcy) and 
      testosterone were determined. The testes and epididymis were used to assess the 
      sperm count, histopathology, lipoperoxidation, cytokine levels, testicular 
      cholesterol, myeloperoxidase, and catalase activity. Spermatozoa were analyzed 
      for morphology, acrosome integrity, mitochondrial activity, and motility. In the 
      testes, HHcy increased the number of abnormal seminiferous tubules, reduced the 
      tubular diameter and the height of the germinal epithelium. In the epididymis, 
      there was tissue remodeling in the head region. Ultimately, voluntary physical 
      exercise training reduced plasma Hcy concentration but did not attenuate 
      HHcy-induced testicular and epididymal disturbances.
CI  - (c) 2021. Society for Reproductive Investigation.
FAU - Dos Santos, Dayane Priscila
AU  - Dos Santos DP
AD  - Department of General Biology, Biological Sciences Center, State University of 
      Londrina, Londrina, Parana, Brazil.
AD  - Department of Pathological Sciences, Biological Sciences Center, State University 
      of Londrina, Londrina, Parana, Brazil.
FAU - Ribeiro, Diogo Farias
AU  - Ribeiro DF
AD  - Department of Physical Education, Center for Physical Education and Sport, State 
      University of Londrina, Londrina, Parana, Brazil.
FAU - Frigoli, Giovanna Fachetti
AU  - Frigoli GF
AD  - Department of General Biology, Biological Sciences Center, State University of 
      Londrina, Londrina, Parana, Brazil.
FAU - Erthal, Rafaela Pires
AU  - Erthal RP
AD  - Department of General Biology, Biological Sciences Center, State University of 
      Londrina, Londrina, Parana, Brazil.
AD  - Department of Pathological Sciences, Biological Sciences Center, State University 
      of Londrina, Londrina, Parana, Brazil.
FAU - da Silva Scarton, Suellen Ribeiro
AU  - da Silva Scarton SR
AD  - Department of General Biology, Biological Sciences Center, State University of 
      Londrina, Londrina, Parana, Brazil.
AD  - Department of Pathological Sciences, Biological Sciences Center, State University 
      of Londrina, Londrina, Parana, Brazil.
FAU - de Lion Siervo, Glaucia Eloisa Munhoz
AU  - de Lion Siervo GEM
AD  - Department of General Biology, Biological Sciences Center, State University of 
      Londrina, Londrina, Parana, Brazil.
AD  - Department of Pathological Sciences, Biological Sciences Center, State University 
      of Londrina, Londrina, Parana, Brazil.
FAU - Seiva, Fabio Rodrigues Ferreira
AU  - Seiva FRF
AD  - Department of Biological Sciences, Center for Biological Sciences, State 
      University of Northern Parana - UENP, Bandeirantes, Parana, Brazil.
FAU - Staurengo-Ferrari, Larissa
AU  - Staurengo-Ferrari L
AD  - Department of Pathological Sciences, Biological Sciences Center, State University 
      of Londrina, Londrina, Parana, Brazil.
FAU - Verri, Waldiceu Aparecido Jr
AU  - Verri WA Jr
AD  - Department of Pathological Sciences, Biological Sciences Center, State University 
      of Londrina, Londrina, Parana, Brazil.
FAU - Deminice, Rafael
AU  - Deminice R
AD  - Department of Physical Education, Center for Physical Education and Sport, State 
      University of Londrina, Londrina, Parana, Brazil.
FAU - Fernandes, Glaura Scantamburlo Alves
AU  - Fernandes GSA
AD  - Department of General Biology, Biological Sciences Center, State University of 
      Londrina, Londrina, Parana, Brazil. glaura@uel.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210907
PL  - United States
TA  - Reprod Sci
JT  - Reproductive sciences (Thousand Oaks, Calif.)
JID - 101291249
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 1.11.1.6 (Catalase)
SB  - IM
MH  - Animals
MH  - Catalase/blood
MH  - Epididymis/metabolism/*physiopathology
MH  - Homocysteine/blood
MH  - Hyperhomocysteinemia/blood/physiopathology/*therapy
MH  - Male
MH  - Mice
MH  - Oxidative Stress/physiology
MH  - Physical Conditioning, Animal/*physiology
MH  - Testis/metabolism/*physiopathology
MH  - Testosterone/blood
MH  - Thiobarbituric Acid Reactive Substances/metabolism
OTO - NOTNLM
OT  - Epididymis
OT  - Homocysteine
OT  - Reproduction
OT  - Sperm
OT  - Testis
OT  - Voluntary physical exercise
EDAT- 2021/09/09 06:00
MHDA- 2022/03/12 06:00
CRDT- 2021/09/08 07:01
PHST- 2021/01/18 00:00 [received]
PHST- 2021/07/26 00:00 [accepted]
PHST- 2021/09/09 06:00 [pubmed]
PHST- 2022/03/12 06:00 [medline]
PHST- 2021/09/08 07:01 [entrez]
AID - 10.1007/s43032-021-00704-1 [pii]
AID - 10.1007/s43032-021-00704-1 [doi]
PST - ppublish
SO  - Reprod Sci. 2022 Jan;29(1):277-290. doi: 10.1007/s43032-021-00704-1. Epub 2021 
      Sep 7.