PMID- 34495385
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20211013
LR  - 20211013
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Linking)
VI  - 413
IP  - 26
DP  - 2021 Nov
TI  - Photocatalytic reduction-based liquid microjunction surface sampling-mass 
      spectrometry for rapid in situ analysis of aromatic amines originating from azo 
      dyes in packaging papers.
PG  - 6649-6660
LID - 10.1007/s00216-021-03631-x [doi]
AB  - A rapid in situ analytical method was developed for the detection of generated 
      carcinogenic aromatic amines from banned azo dyes utilizing a photocatalytic 
      reduction-based liquid microjunction surface sampling (LMJSS)-mass spectrometry 
      (MS) system. We utilized photocatalytic reduction under UV irradiation with 
      TiO(2) as catalyst to have rapid and mild reduction of azo dyes. The reaction 
      conditions were optimized to have complete photocatalytic reduction within 
      2-5 min in pure methanol at room temperature. TiO(2) was immobilized in the inner 
      wall of the capillaries in the LMJSS system to achieve in situ sampling-online 
      rapid reduction-MS detection for aromatic amines originating from azo dyes in 
      packaging surface. The yields of in-tube photocatalytic reduction were near 100% 
      by delivering the azo dye extracts through the capillary at 1 muL/min under UV 
      irradiation. With this design, in situ analysis was completed within 2 min via 
      direct MS detection and 7 min via liquid chromatography (LC)-MS detection. The 
      detection limits for five aromatic amines originating from four different azo 
      dyes were in the range of 1-17 mg/kg with relative standard deviations 
      (RSDs) < 8.5%. In the application of the new method, four carcinogenic aromatic 
      amines were detected and identified in three commercial packaging materials, and 
      the quantitation results were comparable with those obtained by the conventional 
      chemical reduction-LC-MS method (relative recovery, 81-121%). Moreover, due to 
      the spatial resolution of the present method with a flow probe, MS imaging was 
      achieved demonstrating clear azo dye patterns of a lab-made sample.
CI  - (c) 2021. Springer-Verlag GmbH Germany, part of Springer Nature.
FAU - Zhou, Shiwen
AU  - Zhou S
AD  - College of Chemistry and Chemical Engineering, Central South University, 
      Changsha, Hunan, 410083, People's Republic of China.
FAU - Wu, Qian
AU  - Wu Q
AD  - College of Chemistry and Chemical Engineering, Central South University, 
      Changsha, Hunan, 410083, People's Republic of China. qianwu@csu.edu.cn.
FAU - Wang, Zhiguo
AU  - Wang Z
AD  - Technology Center of China Tobacco Hunan Industrial Co. Ltd., Changsha, 410007, 
      Hunan, China.
FAU - Liang, Qiuju
AU  - Liang Q
AD  - Technology Center of China Tobacco Hunan Industrial Co. Ltd., Changsha, 410007, 
      Hunan, China.
FAU - Lu, Hongmei
AU  - Lu H
AD  - College of Chemistry and Chemical Engineering, Central South University, 
      Changsha, Hunan, 410083, People's Republic of China.
LA  - eng
GR  - 201943000834016/the Opening Fund of Cigarette Functional Material Key laboratory 
      of China Tobacco/
GR  - 22074159/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20210908
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
SB  - IM
OTO - NOTNLM
OT  - Azo dyes
OT  - In situ analysis
OT  - Liquid microjunction surface sampling
OT  - Photocatalytic reduction
EDAT- 2021/09/09 06:00
MHDA- 2021/09/09 06:01
CRDT- 2021/09/08 12:27
PHST- 2021/06/06 00:00 [received]
PHST- 2021/08/19 00:00 [accepted]
PHST- 2021/08/16 00:00 [revised]
PHST- 2021/09/09 06:00 [pubmed]
PHST- 2021/09/09 06:01 [medline]
PHST- 2021/09/08 12:27 [entrez]
AID - 10.1007/s00216-021-03631-x [pii]
AID - 10.1007/s00216-021-03631-x [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2021 Nov;413(26):6649-6660. doi: 10.1007/s00216-021-03631-x. 
      Epub 2021 Sep 8.