PMID- 34495780
OWN - NLM
STAT- MEDLINE
DCOM- 20221003
LR  - 20221103
IS  - 1552-3365 (Electronic)
IS  - 0363-5465 (Linking)
VI  - 50
IP  - 12
DP  - 2022 Oct
TI  - Clinical Outcomes of Meniscal Allograft Transplantation With Respect to the 
      Minimal Clinically Important Difference.
PG  - 3440-3446
LID - 10.1177/03635465211036116 [doi]
AB  - BACKGROUND: Arthroscopic-assisted meniscal allograft transplantation (MAT) has 
      become a viable and effective treatment option for young active patients with 
      postmeniscectomy pain. The minimal clinically important difference (MCID) of 
      patient-reported outcome measures (PROMs) is imperative to evaluate the clinical 
      significance of surgical interventions and inform clinical practice guidelines in 
      orthopaedic surgery. PURPOSE: To perform a systematic review of clinical outcome 
      studies of patients undergoing MAT and compare postoperative improvement with 
      established MCID thresholds. STUDY DESIGN: Systematic review and meta-analysis; 
      Level of evidence, 4. METHODS: A systematic review was performed using the 
      PubMed, Web of Science, and Cochrane Library databases. A meta-analysis was 
      performed using data obtained from studies reporting patient-reported outcomes. 
      Subgroup analysis was performed on patients undergoing isolated lateral MAT using 
      fresh-frozen grafts. Weighted mean postoperative improvements in the 
      International Knee Documentation Committee (IKDC), Lysholm, and visual analog 
      scale for pain (VAS pain) were calculated and compared with MCID values to 
      determine if they met the MCID threshold. RESULTS: A total of 35 studies were 
      identified, including 1658 unique patients. Weighted mean postoperative score 
      improvements exceeded MCID thresholds for the VAS pain, IKDC, and Lysholm. 
      Subgroup analysis of patients undergoing isolated lateral fresh-frozen MAT 
      demonstrated postoperative improvements exceeding the MCID for the Lysholm and 
      VAS pain. CONCLUSION: Evaluating postoperative PROMs with respect to the MCID is 
      crucial to evaluate the effect of MAT on functional improvement. The results of 
      the present meta-analysis suggest that postoperative improvements after MAT are 
      clinically meaningful as reflected by PROMs exceeding the MCID threshold for the 
      IKDC, Lysholm, and VAS pain.
FAU - Su, Lisa
AU  - Su L
AD  - David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
FAU - Garcia-Mansilla, Ignacio
AU  - Garcia-Mansilla I
AD  - Knee Division, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
FAU - Kelley, Benjamin
AU  - Kelley B
AD  - Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los 
      Angeles, California, USA.
FAU - Arshi, Armin
AU  - Arshi A
AD  - Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los 
      Angeles, California, USA.
FAU - Fabricant, Peter D
AU  - Fabricant PD
AD  - Pediatric Orthopedic Surgery Service, Hospital for Special Surgery, New York, New 
      York, USA.
FAU - Sherman, Seth L
AU  - Sherman SL
AD  - Stanford University, Stanford, California, USA.
FAU - Jones, Kristofer J
AU  - Jones KJ
AD  - Department of Orthopaedic Surgery, Division of Sports Medicine, David Geffen 
      School of Medicine at UCLA, Los Angeles, California, USA.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20210908
PL  - United States
TA  - Am J Sports Med
JT  - The American journal of sports medicine
JID - 7609541
SB  - IM
MH  - Allografts
MH  - Humans
MH  - Menisci, Tibial/transplantation
MH  - *Meniscus
MH  - *Minimal Clinically Important Difference
MH  - Pain
MH  - Treatment Outcome
OTO - NOTNLM
OT  - meniscal allograft transplant
OT  - meniscal injury
OT  - meniscus
OT  - minimal clinically important difference
OT  - patient-reported outcome measures
OT  - postmeniscectomy pain
EDAT- 2021/09/09 06:00
MHDA- 2022/10/04 06:00
CRDT- 2021/09/08 17:18
PHST- 2021/09/09 06:00 [pubmed]
PHST- 2022/10/04 06:00 [medline]
PHST- 2021/09/08 17:18 [entrez]
AID - 10.1177/03635465211036116 [doi]
PST - ppublish
SO  - Am J Sports Med. 2022 Oct;50(12):3440-3446. doi: 10.1177/03635465211036116. Epub 
      2021 Sep 8.