PMID- 34496493
OWN - NLM
STAT- MEDLINE
DCOM- 20210910
LR  - 20210910
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 50
IP  - 9
DP  - 2021 Sep 8
TI  - [Inflammatory myofibroblastic tumors of the urinary bladder: a 
      clinicopathological study of ten cases].
PG  - 1024-1028
LID - 10.3760/cma.j.cn112151-20210113-00039 [doi]
AB  - 0bjective To investigate the clinicopathological features,immunohistochemical 
      phenotypes, molecular genetic alterations,diagnosis and differential diagnosis of 
      inflammatory myofibroblastic tumor (IMT) of the urinary bladder. Methods: Ten 
      cases of IMT of the urinary bladder (three cases at Ningbo Diagnostic Pathology 
      Center from September 2011 to December 2020, five in-house diagnosed cases and 
      two consultation cases at Shanghai Rui Jin Hospital from June 2011 to December 
      2020) were collected retrospectively. The clinicopathologic features and 
      immunophenotypic profiles were studied by light microscopy and 
      immunohistochemistry (EnVision method). The translocation of ALK gene was 
      detected by fluorescence in situ hybridization (FISH). Results: Of the 10 
      patients, eight were male and two were female. The patients' age range was 16 to 
      62 years (median 36 years).The main clinical presentation was hematuria and 
      urinary irritation. Three cases were located at the dome of the urinary bladder, 
      four cases were in the left lateral wall and the remaining three cases were in 
      the right lateral wall. The tumor size ranged from 1.5 cm to 8.5 cm. In eight 
      cases, the tumors were mainly submucosal, and in some cases extending to the 
      muscular layer of the urinary bladder. In two cases, the tumors were mainly 
      located in the muscular layer and focally extended to the submucosa and 
      adventitia. Histologically, four cases had the nodular fasciitis-like pattern, 
      three cases had fibrohistiocytoma-like pattern, two cases had mixed histologic 
      patterns and the remaining case showed leiomyosarcoma-like histologic features. 
      Immunohistochemically, the tumor cells expressed SMA (10/10),calponin 
      (9/10),desmin (6/10) and CKpan (9/10). Cytoplasmic staining for ALK1 and ALK 
      (5A4) was detected in 7 of 10 cases and 8 of 10 cases, respectively. Nuclear and 
      cytoplasmic staining for ALK (D5F3) was detected in 7 of 10 cases. Among eight 
      cases with material available for FISH analysis, ALK rearrangement was present in 
      five cases. Follow-up data were available in eight patients and none had local 
      recurrence nor distant metastasis. Conclusion: IMT of the urinary bladder is an 
      uncommon mesenchymal neoplasm with intermediate malignant potential.It has 
      special clinicopathologic features, and a minority of cases have local tumor 
      recurrence.
FAU - Zhang, H Z
AU  - Zhang HZ
AD  - Department of Pathology, Ningbo Diagnostic Pathology Center, Zhejiang Province, 
      Ningbo 315000, China.
FAU - Wang, S Y
AU  - Wang SY
AD  - Department of Pathology, Ningbo Diagnostic Pathology Center, Zhejiang Province, 
      Ningbo 315000, China.
FAU - Dong, L
AU  - Dong L
AD  - Department of Pathology, Rui Jin Hospital, School of Medicine, Shanghai Jiaotong 
      University, Shanghai 200020, China.
FAU - Yang, X Q
AU  - Yang XQ
AD  - Department of Pathology, Rui Jin Hospital, School of Medicine, Shanghai Jiaotong 
      University, Shanghai 200020, China.
FAU - Wang, C F
AU  - Wang CF
AD  - Department of Pathology, Rui Jin Hospital, School of Medicine, Shanghai Jiaotong 
      University, Shanghai 200020, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anaplastic Lymphoma Kinase/genetics
MH  - Biomarkers, Tumor
MH  - China
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Receptor Protein-Tyrosine Kinases/genetics
MH  - Retrospective Studies
MH  - *Urinary Bladder Neoplasms/genetics
MH  - Young Adult
EDAT- 2021/09/10 06:00
MHDA- 2021/09/11 06:00
CRDT- 2021/09/09 03:52
PHST- 2021/09/09 03:52 [entrez]
PHST- 2021/09/10 06:00 [pubmed]
PHST- 2021/09/11 06:00 [medline]
AID - 10.3760/cma.j.cn112151-20210113-00039 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2021 Sep 8;50(9):1024-1028. doi: 
      10.3760/cma.j.cn112151-20210113-00039.