PMID- 34497004
OWN - NLM
STAT- MEDLINE
DCOM- 20211101
LR  - 20211101
IS  - 2050-084X (Electronic)
IS  - 2050-084X (Linking)
VI  - 10
DP  - 2021 Sep 9
TI  - The corticospinal tract primarily modulates sensory inputs in the mouse lumbar 
      cord.
LID - 10.7554/eLife.65304 [doi]
LID - e65304
AB  - It is generally assumed that the main function of the corticospinal tract (CST) 
      is to convey motor commands to bulbar or spinal motoneurons. Yet the CST has also 
      been shown to modulate sensory signals at their entry point in the spinal cord 
      through primary afferent depolarization (PAD). By sequentially investigating 
      different routes of corticofugal pathways through electrophysiological recordings 
      and an intersectional viral strategy, we here demonstrate that motor and sensory 
      modulation commands in mice belong to segregated paths within the CST. Sensory 
      modulation is executed exclusively by the CST via a population of lumbar 
      interneurons located in the deep dorsal horn. In contrast, the cortex conveys the 
      motor command via a relay in the upper spinal cord or supraspinal motor centers. 
      At lumbar level, the main role of the CST is thus the modulation of sensory 
      inputs, which is an essential component of the selective tuning of sensory 
      feedback used to ensure well-coordinated and skilled movement.
CI  - (c) 2021, Moreno-Lopez et al.
FAU - Moreno-Lopez, Yunuen
AU  - Moreno-Lopez Y
AUID- ORCID: 0000-0002-4023-849X
AD  - Institut des Neurosciences Cellulaires et Integrees, CNRS - Universite de 
      Strasbourg, Strasbourg, France.
FAU - Bichara, Charlotte
AU  - Bichara C
AUID- ORCID: 0000-0002-2154-3915
AD  - Institut des Neurosciences Cellulaires et Integrees, CNRS - Universite de 
      Strasbourg, Strasbourg, France.
FAU - Delbecq, Gilles
AU  - Delbecq G
AD  - Institut des Neurosciences Cellulaires et Integrees, CNRS - Universite de 
      Strasbourg, Strasbourg, France.
FAU - Isope, Philippe
AU  - Isope P
AUID- ORCID: 0000-0002-0630-5935
AD  - Institut des Neurosciences Cellulaires et Integrees, CNRS - Universite de 
      Strasbourg, Strasbourg, France.
FAU - Cordero-Erausquin, Matilde
AU  - Cordero-Erausquin M
AUID- ORCID: 0000-0002-1623-1773
AD  - Institut des Neurosciences Cellulaires et Integrees, CNRS - Universite de 
      Strasbourg, Strasbourg, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210909
PL  - England
TA  - Elife
JT  - eLife
JID - 101579614
SB  - IM
MH  - Afferent Pathways
MH  - Animals
MH  - Axons
MH  - Brain
MH  - Cerebral Cortex
MH  - Interneurons/metabolism
MH  - Mice
MH  - Motor Neurons
MH  - Neurons/metabolism
MH  - Pyramidal Tracts/*physiology
MH  - Spinal Cord/pathology/*physiology
MH  - Spinal Cord Dorsal Horn
PMC - PMC8439650
OTO - NOTNLM
OT  - corticospinal
OT  - mouse
OT  - neuroscience
OT  - primary afferent depolarization
OT  - sensorimotor
COIS- YM, CB, PI, MC None, GD none
EDAT- 2021/09/10 06:00
MHDA- 2021/11/03 06:00
PMCR- 2021/09/09
CRDT- 2021/09/09 05:53
PHST- 2020/11/30 00:00 [received]
PHST- 2021/07/27 00:00 [accepted]
PHST- 2021/09/09 05:53 [entrez]
PHST- 2021/09/10 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2021/09/09 00:00 [pmc-release]
AID - 65304 [pii]
AID - 10.7554/eLife.65304 [doi]
PST - epublish
SO  - Elife. 2021 Sep 9;10:e65304. doi: 10.7554/eLife.65304.