PMID- 34498757
OWN - NLM
STAT- MEDLINE
DCOM- 20220127
LR  - 20220127
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 96
IP  - 2
DP  - 2022 Feb
TI  - (68) Ga-DOTATATE PET/CT imaging in endogenous hyperinsulinemic hypoglycemia: A 
      tertiary endocrine centre experience.
PG  - 190-199
LID - 10.1111/cen.14586 [doi]
AB  - OBJECTIVE: Literature regarding utility of (68) Ga-DOTATATE PET/CT in insulinoma 
      localization across various subgroups [benign/malignant/multiple endocrine 
      neoplasia-1 (MEN-1) syndrome associated] remains scarce. In this study, the 
      performance of (68) Ga-DOTATATE PET/CT was compared with contrast-enhanced 
      computed tomography (CECT) and (68) Ga-NODAGA-Exendin-4 PET/CT (whenever 
      available) in an endogenous hyperinsulinemic hypoglycemia (EHH) cohort. DESIGN: 
      Retrospective audit. PATIENTS: EHH patients [N = 36, lesions (n) = 49, final 
      diagnosis: benign sporadic insulinoma (BSI) (N = 20), malignant insulinoma 
      (N = 4, n = 14), MEN-1 syndrome associated insulinoma (N = 9, n = 15), Munchausen 
      syndrome (N = 2) and drug-induced hypoglycemia (N = 1)] having both preoperative 
      imaging modalities (CECT and (68) Ga-DOTATATE PET/CT). MEASUREMENTS: Per-lesion 
      sensitivity (Sn) and positive predictive value (PPV) for histopathological 
      diagnosis of insulinoma. RESULTS: Sn and PPV of (68) Ga-DOTATATE PET/CT were 
      67.3% and 89.2%; 55% and 100%; 85.7% and 100%; and 66.7% and 77% for overall EHH, 
      BSI, malignant, and MEN-1 syndrome associated insulinoma cohorts respectively. 
      Despite having comparatively lower sensitivity in BSI cohort, (68) Ga-DOTATATE 
      PET/CT localized a pancreatic tail lesion missed by other modalities. (68) 
      Ga-DOTATATE PET/CT had comparatively higher sensitivity in malignant insulinoma 
      than BSI cohort. (68) Ga-DOTATATE PET/CT also paved the way for successful 
      response to (177) Lu-based peptide receptor radionuclide therapy (PRRT). In MEN-1 
      cases, lower PPV as compared with BSI was due to uptake in non-insulinoma 
      pancreatic neuroendocrine tumours (Pan-NET). CONCLUSIONS: (68) Ga-DOTATATE PET/CT 
      has supplemental role in selected cases of BSI with negative and/or discordant 
      results with CECT and (68) Ga-NODAGA-Exendin-4 PET/CT. In malignant insulinoma, 
      (68) Ga-DOTATATE-PET/CT has an additional theranostic potential. Interference due 
      to uptake in non-insulinoma Pan-NET in MEN-1 syndrome may hinder insulinoma 
      localization with (68) Ga-DOTATATE-PET/CT.
CI  - (c) 2021 John Wiley & Sons Ltd.
FAU - Shah, Ravikumar
AU  - Shah R
AUID- ORCID: 0000-0001-6275-5650
AD  - Department of Endocrinology, Seth GS Medical College & KEM Hospital, Mumbai, 
      India.
FAU - Sehemby, Manjeetkaur
AU  - Sehemby M
AD  - Department of Endocrinology, Seth GS Medical College & KEM Hospital, Mumbai, 
      India.
FAU - Garg, Robin
AU  - Garg R
AD  - Department of Endocrinology, Seth GS Medical College & KEM Hospital, Mumbai, 
      India.
FAU - Purandare, Nilendu
AU  - Purandare N
AD  - Department of Radiodiagnosis and Imaging, Tata Memorial Center, Mumbai, India.
FAU - Hira, Priya
AU  - Hira P
AD  - Department of Radiodiagnosis, Seth GS Medical College & KEM Hospital, Mumbai, 
      India.
FAU - Mahajan, Abhishek
AU  - Mahajan A
AD  - Department of Radiodiagnosis and Imaging, Tata Memorial Center, Mumbai, India.
FAU - Lele, Vikram
AU  - Lele V
AD  - Department of Nuclear Medicine & PET/CT, Jaslok Hospital & Research Center, 
      Mumbai, India.
FAU - Malhotra, Gaurav
AU  - Malhotra G
AD  - Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre, 
      Mumbai, India.
FAU - Verma, Priyanka
AU  - Verma P
AD  - Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre, 
      Mumbai, India.
FAU - Rojekar, Amey
AU  - Rojekar A
AD  - Department of Pathology, Seth GS Medical College & KEM Hospital, Mumbai, India.
FAU - Dalvi, Abhay
AU  - Dalvi A
AD  - Department of General Surgery, Seth GS Medical College & KEM Hospital, Mumbai, 
      India.
FAU - Uchino, Shinya
AU  - Uchino S
AD  - Endocrine Surgical Department, Noguchi Thyroid Clinic and Hospital Foundation, 
      Oita, Japan.
FAU - Rastogi, Shivam
AU  - Rastogi S
AD  - Department of Radiodiagnosis and Imaging, Tata Memorial Center, Mumbai, India.
FAU - Lila, Anurag
AU  - Lila A
AUID- ORCID: 0000-0002-9623-4471
AD  - Department of Endocrinology, Seth GS Medical College & KEM Hospital, Mumbai, 
      India.
FAU - Patil, Virendra
AU  - Patil V
AD  - Department of Endocrinology, Seth GS Medical College & KEM Hospital, Mumbai, 
      India.
FAU - Shah, Nalini
AU  - Shah N
AD  - Department of Endocrinology, Seth GS Medical College & KEM Hospital, Mumbai, 
      India.
FAU - Bandgar, Tushar
AU  - Bandgar T
AUID- ORCID: 0000-0002-6902-4639
AD  - Department of Endocrinology, Seth GS Medical College & KEM Hospital, Mumbai, 
      India.
LA  - eng
PT  - Journal Article
DEP - 20210908
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Organometallic Compounds)
RN  - 0 (copper dotatate CU-64)
SB  - IM
MH  - *Congenital Hyperinsulinism
MH  - Humans
MH  - *Insulinoma/diagnostic imaging
MH  - *Neuroendocrine Tumors
MH  - *Organometallic Compounds
MH  - Positron Emission Tomography Computed Tomography
MH  - Positron-Emission Tomography
MH  - Radionuclide Imaging
MH  - Retrospective Studies
OTO - NOTNLM
OT  - 68Ga-DOTATATE-PET/CT,CECT
OT  - endogenous hyperinsulinemic hypoglycemia (EHH)
OT  - insulinoma
EDAT- 2021/09/10 06:00
MHDA- 2022/01/28 06:00
CRDT- 2021/09/09 08:49
PHST- 2021/08/08 00:00 [revised]
PHST- 2021/05/08 00:00 [received]
PHST- 2021/08/10 00:00 [accepted]
PHST- 2021/09/10 06:00 [pubmed]
PHST- 2022/01/28 06:00 [medline]
PHST- 2021/09/09 08:49 [entrez]
AID - 10.1111/cen.14586 [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2022 Feb;96(2):190-199. doi: 10.1111/cen.14586. Epub 2021 
      Sep 8.