PMID- 34502352
OWN - NLM
STAT- MEDLINE
DCOM- 20211028
LR  - 20211028
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 17
DP  - 2021 Aug 31
TI  - An In Vitro Comparative Study of the Effects of Tetrabromobisphenol A and 
      Tetrabromobisphenol S on Human Erythrocyte Membranes-Changes in ATP Level, 
      Perturbations in Membrane Fluidity, Alterations in Conformational State and 
      Damage to Proteins.
LID - 10.3390/ijms22179443 [doi]
LID - 9443
AB  - Brominated flame retardants (BFRs) are substances used to reduce the flammability 
      of plastics. Among this group, tetrabormobisphenol A (TBBPA) is currently 
      produced and used on the greatest scale, but due to the emerging reports on its 
      potential toxicity, tetrabromobisphenol S (TBBPS)-a compound with a very similar 
      structure-is used as an alternative. Due to the fact that the compounds in 
      question are found in the environment and in biological samples from living 
      organisms, including humans, and due to the insufficient toxicological knowledge 
      about them, it is necessary to assess their impacts on living organisms and 
      verify the validity of TBBPA replacement by TBBPS. The RBC membrane was chosen as 
      the research model. This is a widely accepted research model for assessing the 
      toxicity of xenobiotics, and it is the first barrier to compounds entering 
      circulation. It was found that TBBPA and TBBPS caused increases in the fluidity 
      of the erythrocyte membrane in their hydrophilic layer, and conformational 
      changes to membrane proteins. They also caused thiol group elevation, an increase 
      in lipid peroxidation (TBBPS only) and decreases in the level of ATP in cells. 
      They also caused changes in the size and shape of RBCs. TBBPA caused changes in 
      the erythrocyte membrane at lower concentrations compared to TBBPS at an 
      occupational exposure level.
FAU - Jarosiewicz, Monika
AU  - Jarosiewicz M
AUID- ORCID: 0000-0003-3104-4025
AD  - Department of Biophysics of Environmental Pollution, Faculty of Biology and 
      Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, 
      Poland.
AD  - Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, 
      University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
FAU - Duchnowicz, Piotr
AU  - Duchnowicz P
AUID- ORCID: 0000-0002-3514-9716
AD  - Department of Biophysics of Environmental Pollution, Faculty of Biology and 
      Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, 
      Poland.
FAU - Jarosiewicz, Pawel
AU  - Jarosiewicz P
AUID- ORCID: 0000-0002-9104-2593
AD  - European Regional Centre for Ecohydrology of the Polish Academy of Sciences, 
      Tylna 3, 90-364 Lodz, Poland.
FAU - Huras, Bogumila
AU  - Huras B
AD  - Lukasiewicz Research Network, Institute of Industrial Organic Chemistry, Annopol 
      6 Str, 03-236 Warsaw, Poland.
FAU - Bukowska, Bozena
AU  - Bukowska B
AUID- ORCID: 0000-0003-3044-2953
AD  - Department of Biophysics of Environmental Pollution, Faculty of Biology and 
      Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, 
      Poland.
LA  - eng
GR  - 2017/27/N/NZ7/00548/National Science Centre, Poland/
PT  - Comparative Study
PT  - Journal Article
DEP - 20210831
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Flame Retardants)
RN  - 0 (Membrane Proteins)
RN  - 0 (Polybrominated Biphenyls)
RN  - 0 (Proteins)
RN  - 0 (tetrabromobisphenol S)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - FQI02RFC3A (tetrabromobisphenol A)
SB  - IM
MH  - Adenosine Triphosphate/metabolism/pharmacology
MH  - Erythrocyte Membrane/*drug effects/metabolism
MH  - Erythrocytes/drug effects
MH  - Flame Retardants/toxicity
MH  - Healthy Volunteers
MH  - Humans
MH  - Membrane Fluidity/drug effects
MH  - Membrane Proteins/drug effects/metabolism
MH  - Polybrominated Biphenyls/chemistry/*pharmacology/toxicity
MH  - Protein Conformation/drug effects
MH  - Proteins/pharmacology
PMC - PMC8431071
OTO - NOTNLM
OT  - erythrocyte membrane
OT  - erythrocytes
OT  - retardants
OT  - tetrabromobisphenol A
OT  - tetrabromobisphenol S
COIS- The authors declare no conflict of interest.
EDAT- 2021/09/11 06:00
MHDA- 2021/10/29 06:00
PMCR- 2021/08/31
CRDT- 2021/09/10 01:07
PHST- 2021/08/02 00:00 [received]
PHST- 2021/08/26 00:00 [revised]
PHST- 2021/08/27 00:00 [accepted]
PHST- 2021/09/10 01:07 [entrez]
PHST- 2021/09/11 06:00 [pubmed]
PHST- 2021/10/29 06:00 [medline]
PHST- 2021/08/31 00:00 [pmc-release]
AID - ijms22179443 [pii]
AID - ijms-22-09443 [pii]
AID - 10.3390/ijms22179443 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Aug 31;22(17):9443. doi: 10.3390/ijms22179443.