PMID- 34503541 OWN - NLM STAT- MEDLINE DCOM- 20210917 LR - 20210917 IS - 1550-2783 (Electronic) IS - 1550-2783 (Linking) VI - 18 IP - 1 DP - 2021 Sep 9 TI - The effects of phosphocreatine disodium salts plus blueberry extract supplementation on muscular strength, power, and endurance. PG - 60 LID - 10.1186/s12970-021-00456-y [doi] LID - 60 AB - BACKGROUND: Numerous studies have demonstrated the efficacy of creatine supplementation for improvements in exercise performance. Few studies, however, have examined the effects of phosphocreatine supplementation on exercise performance. Furthermore, while polyphenols have antioxidant and anti-inflammatory properties, little is known regarding the influence of polyphenol supplementation on muscular strength, power, and endurance. Thus, the purpose of the present study was to compare the effects of 28 days of supplementation with phosphocreatine disodium salts plus blueberry extract (PCDSB), creatine monohydrate (CM), and placebo on measures of muscular strength, power, and endurance. METHODS: Thirty-three men were randomly assigned to consume either PCDSB, CM, or placebo for 28 days. Peak torque (PT), average power (AP), and percent decline for peak torque (PT%) and average power (AP%) were assessed from a fatigue test consisting of 50 maximal, unilateral, isokinetic leg extensions at 180 degrees .s(- 1) before and after the 28 days of supplementation. Individual responses were assessed to examine the proportion of subjects that exceeded a minimal important difference (MID). RESULTS: The results demonstrated significant (p < 0.05) improvements in PT for the PCDSB and CM groups from pre- (99.90 +/- 22.47 N.m and 99.95 +/- 22.50 N.m, respectively) to post-supplementation (119.22 +/- 29.87 N.m and 111.97 +/- 24.50 N.m, respectively), but no significant (p = 0.112) change for the placebo group. The PCDSB and CM groups also exhibited significant improvements in AP from pre- (140.18 +/- 32.08 W and 143.42 +/- 33.84 W, respectively) to post-supplementation (170.12 +/- 42.68 W and 159.78 +/- 31.20 W, respectively), but no significant (p = 0.279) change for the placebo group. A significantly (p < 0.05) greater proportion of subjects in the PCDSB group exceeded the MID for PT compared to the placebo group, but there were no significant (p > 0.05) differences in the proportion of subjects exceeding the MID between the CM and placebo groups or between the CM and PCDSB groups. CONCLUSIONS: These findings indicated that for the group mean responses, 28 days of supplementation with both PCDSB and CM resulted in increases in PT and AP. The PCDSB, however, may have an advantage over CM when compared to the placebo group for the proportion of individuals that respond favorably to supplementation with meaningful increases in muscular strength. CI - (c) 2021. The Author(s). FAU - Anders, John Paul V AU - Anders JPV AUID- ORCID: 0000-0002-6416-3613 AD - Department of Nutrition and Human Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68510, USA. janders@huskers.unl.edu. FAU - Neltner, Tyler J AU - Neltner TJ AD - Department of Nutrition and Human Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68510, USA. FAU - Smith, Robert W AU - Smith RW AD - Department of Nutrition and Human Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68510, USA. FAU - Keller, Joshua L AU - Keller JL AD - Department of Health, Kinesiology and Sport, University of South Alabama, Mobile, AL, 36688, USA. FAU - Housh, Terry J AU - Housh TJ AD - Department of Nutrition and Human Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68510, USA. FAU - Daugherty, F Joseph AU - Daugherty FJ AD - Phenolics LLC, Omaha, NE, 68144, USA. FAU - Tempesta, Michael S AU - Tempesta MS AD - Phenolics LLC, Omaha, NE, 68144, USA. FAU - Dash, Alekha K AU - Dash AK AD - Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Omaha, NE, 68178, USA. FAU - Munt, Daniel J AU - Munt DJ AD - Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Omaha, NE, 68178, USA. FAU - Schmidt, Richard J AU - Schmidt RJ AD - Department of Nutrition and Human Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68510, USA. FAU - Johnson, Glen O AU - Johnson GO AD - Department of Nutrition and Human Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68510, USA. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20210909 PL - United States TA - J Int Soc Sports Nutr JT - Journal of the International Society of Sports Nutrition JID - 101234168 RN - 0 (Plant Extracts) RN - 020IUV4N33 (Phosphocreatine) RN - MU72812GK0 (Creatine) SB - IM MH - Blueberry Plants/chemistry MH - Creatine MH - Dietary Supplements MH - Double-Blind Method MH - Humans MH - Male MH - Muscle Strength/*drug effects MH - Muscle, Skeletal/*drug effects MH - Phosphocreatine/*pharmacology MH - Physical Endurance/*drug effects MH - Plant Extracts/*pharmacology MH - Torque MH - Young Adult PMC - PMC8427883 OTO - NOTNLM OT - Antioxidant OT - Blueberry OT - Creatine monohydrate OT - Isokinetic OT - Muscular endurance OT - Phosphocreatine OT - Polyphenols OT - Power OT - Strength COIS- FJD is the Managing Partner of Phenolics, LLC which developed the blend of phosphocreatine disodium salts plus blueberry extract. Phenolics, however, provided no funding for the current study. EDAT- 2021/09/11 06:00 MHDA- 2021/09/18 06:00 PMCR- 2021/09/09 CRDT- 2021/09/10 05:36 PHST- 2021/03/29 00:00 [received] PHST- 2021/07/01 00:00 [accepted] PHST- 2021/09/10 05:36 [entrez] PHST- 2021/09/11 06:00 [pubmed] PHST- 2021/09/18 06:00 [medline] PHST- 2021/09/09 00:00 [pmc-release] AID - 10.1186/s12970-021-00456-y [pii] AID - 456 [pii] AID - 10.1186/s12970-021-00456-y [doi] PST - epublish SO - J Int Soc Sports Nutr. 2021 Sep 9;18(1):60. doi: 10.1186/s12970-021-00456-y.