PMID- 34503658
OWN - NLM
STAT- MEDLINE
DCOM- 20211108
LR  - 20211108
IS  - 1532-3129 (Electronic)
IS  - 0021-9975 (Linking)
VI  - 187
DP  - 2021 Aug
TI  - Pathogenicity of Porcine Circovirus Type 2d (PCV2d) in Pigs Infected with PCV2d 
      or Co-infected with Mycoplasma hyopneumoniae and PCV2d or with Porcine 
      Reproductive and Respiratory Syndrome Virus and PCV2d.
PG  - 75-82
LID - S0021-9975(21)00089-X [pii]
LID - 10.1016/j.jcpa.2021.07.004 [doi]
AB  - The objective of this study was to determine the pathogenicity of porcine 
      circovirus type 2d (PCV2d) in pigs inoculated intranasally with PCV2d alone, 
      PCV2d in combination with Mycoplasma hyopneumoniae or PCV2d in combination with 
      porcine reproductive and respiratory syndrome virus (PRRSV). Pigs infected with 
      PCV2d alone were asymptomatic. All pigs inoculated with either M. hyopneumoniae 
      and PCV2d or with PCV2d and PRRSV developed porcine circovirus-associated disease 
      (PCVAD), as characterized by a sudden onset of clinical signs and disseminated 
      granulomatous inflammation. Inflammation was mainly present in lymph nodes and 
      spleen, and occasionally in liver and kidney. Pigs in both of these dually 
      infected groups also had significantly higher (P <0.05) microscopic lymphoid 
      lesion scores and a significantly higher (P <0.05) number of PCV2-positive cells 
      in lymph node tissue than did pigs inoculated with PCV2d alone. The M. 
      hyopneumoniae and PRRSV combination potentiated the PCV2d load in the blood. 
      Co-infection with PRRSV and PCV2d resulted in a significantly higher blood load 
      of PCV2d compared with the M. hyopneumoniae and PCV2d combination. Successful 
      reproduction of PCVAD in pigs appears to require PCV2d with at least one 
      additional infectious agent, such as M. hyopneumoniae or PRRSV, for the full 
      manifestation of disease.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Oh, Taehwan
AU  - Oh T
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Park, Kee Hwan
AU  - Park KH
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Yang, Siyeon
AU  - Yang S
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Cho, Hyejean
AU  - Cho H
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Suh, Jeongmin
AU  - Suh J
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Gwanak-gu, Seoul, Republic of Korea. Electronic address: 
      swine@snu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20210813
PL  - England
TA  - J Comp Pathol
JT  - Journal of comparative pathology
JID - 0102444
SB  - IM
MH  - Animals
MH  - *Circoviridae Infections/veterinary
MH  - Circovirus/pathogenicity
MH  - Coinfection/veterinary
MH  - Mycoplasma hyopneumoniae/pathogenicity
MH  - *Pneumonia of Swine, Mycoplasmal
MH  - *Porcine Reproductive and Respiratory Syndrome
MH  - Porcine respiratory and reproductive syndrome virus/pathogenicity
MH  - Swine
MH  - *Swine Diseases
MH  - Virulence
OTO - NOTNLM
OT  - Mycoplasma hyopneumoniae
OT  - porcine circovirus type 2d
OT  - porcine circovirus-associated disease
OT  - porcine respiratory and reproductive syndrome virus
EDAT- 2021/09/11 06:00
MHDA- 2021/11/09 06:00
CRDT- 2021/09/10 05:40
PHST- 2021/03/18 00:00 [received]
PHST- 2021/06/09 00:00 [revised]
PHST- 2021/07/10 00:00 [accepted]
PHST- 2021/09/10 05:40 [entrez]
PHST- 2021/09/11 06:00 [pubmed]
PHST- 2021/11/09 06:00 [medline]
AID - S0021-9975(21)00089-X [pii]
AID - 10.1016/j.jcpa.2021.07.004 [doi]
PST - ppublish
SO  - J Comp Pathol. 2021 Aug;187:75-82. doi: 10.1016/j.jcpa.2021.07.004. Epub 2021 Aug 
      13.