PMID- 34504423
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210911
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 12
DP  - 2021
TI  - A Polysaccharide From the Whole Plant of Plantago asiatica L. Enhances the 
      Antitumor Activity of Dendritic Cell-Based Immunotherapy Against Breast Cancer.
PG  - 678865
LID - 10.3389/fphar.2021.678865 [doi]
LID - 678865
AB  - Dendritic cells (DCs) are the most potent professional antigen-presenting cells 
      (APCs) that mediate T-cell immune responses. Breast cancer is one of the most 
      commonly diagnosed diseases and its mortality rate is higher than any other 
      cancer in both humans and canines. Plantain polysaccharide (PLP), extracted from 
      the whole plant of Plantago asiatica L., could promote the maturation of DCs. In 
      this research, we found that PLP could upregulate the maturation of DCs both in 
      vitro and in vivo. PLP-activated DCs could stimulate lymphocytes' proliferation 
      and differentiate naive T cells into cytotoxic T cells. Tumor antigen-specific 
      lymphocyte responses were enhanced by PLP and CIPp canine breast tumor cells 
      lysate-pulsed DCs, and PLP and CIPp-cell-lysate jointly stimulated DCs cocultured 
      with lymphocytes having the great cytotoxicity on CIPp cells. In the 4T1 murine 
      breast tumor model, PLP could control the size of breast tumors and improve 
      immunity by recruiting DCs, macrophages, and CD4(+) and CD8(+) T cells in the 
      tumor microenvironment. These results indicated that PLP could achieve 
      immunotherapeutic effects and improve immunity in the breast tumor model.
CI  - Copyright (c) 2021 Gao, Zhang, Cui, Zhang, Ming, Hao, Xu, Cheng, Zhang, Jin, Lin 
      and Lin.
FAU - Gao, Jiafeng
AU  - Gao J
AD  - The Clinical Department, College of Veterinary Medicine, China Agricultural 
      University, Beijing, China.
FAU - Zhang, Yi-Nan
AU  - Zhang YN
AD  - Institute of Biomaterials and Biomedical Engineering, University of Toronto, 
      Toronto, Toronto, Canada.
FAU - Cui, Jingwen
AU  - Cui J
AD  - The Clinical Department, College of Veterinary Medicine, China Agricultural 
      University, Beijing, China.
FAU - Zhang, Jiatong
AU  - Zhang J
AD  - The Clinical Department, College of Veterinary Medicine, China Agricultural 
      University, Beijing, China.
FAU - Ming, Yuexiang
AU  - Ming Y
AD  - The Clinical Department, College of Veterinary Medicine, China Agricultural 
      University, Beijing, China.
FAU - Hao, Zhihui
AU  - Hao Z
AD  - The Clinical Department, College of Veterinary Medicine, China Agricultural 
      University, Beijing, China.
AD  - Center of Research and Innovation of Chinese Traditional Veterinary Medicine, 
      China Agricultural University, Beijing, China.
FAU - Xu, Huihao
AU  - Xu H
AD  - The Clinical Department, College of Veterinary Medicine, China Agricultural 
      University, Beijing, China.
FAU - Cheng, Nan
AU  - Cheng N
AD  - The Clinical Department, College of Veterinary Medicine, China Agricultural 
      University, Beijing, China.
FAU - Zhang, Di
AU  - Zhang D
AD  - The Clinical Department, College of Veterinary Medicine, China Agricultural 
      University, Beijing, China.
FAU - Jin, Yipeng
AU  - Jin Y
AD  - The Clinical Department, College of Veterinary Medicine, China Agricultural 
      University, Beijing, China.
FAU - Lin, Degui
AU  - Lin D
AD  - The Clinical Department, College of Veterinary Medicine, China Agricultural 
      University, Beijing, China.
FAU - Lin, Jiahao
AU  - Lin J
AD  - The Clinical Department, College of Veterinary Medicine, China Agricultural 
      University, Beijing, China.
AD  - Center of Research and Innovation of Chinese Traditional Veterinary Medicine, 
      China Agricultural University, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20210824
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC8421731
OTO - NOTNLM
OT  - Plantago asiatica L
OT  - breast tumor
OT  - cytotoxic T cells
OT  - dendritic cells
OT  - immunotherapy
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/09/11 06:00
MHDA- 2021/09/11 06:01
PMCR- 2021/08/24
CRDT- 2021/09/10 06:59
PHST- 2021/03/10 00:00 [received]
PHST- 2021/07/26 00:00 [accepted]
PHST- 2021/09/10 06:59 [entrez]
PHST- 2021/09/11 06:00 [pubmed]
PHST- 2021/09/11 06:01 [medline]
PHST- 2021/08/24 00:00 [pmc-release]
AID - 678865 [pii]
AID - 10.3389/fphar.2021.678865 [doi]
PST - epublish
SO  - Front Pharmacol. 2021 Aug 24;12:678865. doi: 10.3389/fphar.2021.678865. 
      eCollection 2021.