PMID- 34504626
OWN - NLM
STAT- MEDLINE
DCOM- 20220124
LR  - 20230630
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2021
DP  - 2021
TI  - Development and Validation of Diagnostic Models for Hand-Foot-and-Mouth Disease 
      in Children.
PG  - 1923636
LID - 10.1155/2021/1923636 [doi]
LID - 1923636
AB  - OBJECTIVE: To find risk markers and develop new clinical predictive models for 
      the differential diagnosis of hand-foot-and-mouth disease (HFMD) with varying 
      degrees of disease. METHODS: 19766 children with HFMD and 64 clinical indexes 
      were included in this study. The patients included in this study were divided 
      into the mild patients' group (mild) with 12292 cases, severe patients' group 
      (severe) with 6508 cases, and severe patients with respiratory failure group 
      (severe-RF) with 966 cases. Single-factor analysis was carried out on 64 indexes 
      collected from patients when they were admitted to the hospital, and the indexes 
      with statistical differences were selected as the prediction factors. Binary 
      multivariate logistic regression analysis was used to construct the prediction 
      models and calculate the adjusted odds ratio (OR). RESULTS: SP, DP, NEUT#, NEUT%, 
      RDW-SD, RDW-CV, GGT, CK/CK-MB, and Glu were risk markers in mild/severe, 
      mild/severe-RF, and severe/severe-RF. Glu was a diagnostic marker for 
      mild/severe-RF (AUROC = 0.80, 95% CI: 0.78-0.82); the predictive model 
      constructed by temperature, SP, MOMO%, EO%, RDW-SD, GLB, CRP, Glu, BUN, and Cl 
      could be used for the differential diagnosis of mild/severe (AUROC > 0.84); the 
      predictive model constructed by SP, age, NEUT#, PCT, TBIL, GGT, Mb, beta2MG, Glu, 
      and Ca could be used for the differential diagnosis of severe/severe-RF (AUROC > 
      0.76). CONCLUSION: By analyzing clinical indicators, we have found the risk 
      markers of HFMD and established suitable predictive models.
CI  - Copyright (c) 2021 Feng Zhuo et al.
FAU - Zhuo, Feng
AU  - Zhuo F
AD  - Pediatric Cardiology Center, Jiangxi Provincial Children's Hospital, Nanchang, 
      Jiangxi 330006, China.
FAU - Yu, Mengjie
AU  - Yu M
AD  - Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical 
      University, Nanjing, 210009 Jiangsu, China.
FAU - Chen, Qiang
AU  - Chen Q
AD  - Department of Respiratory, Jiangxi Provincial Children's Hospital, Nanchang, 
      Jiangxi 330006, China.
FAU - Li, Nuoya
AU  - Li N
AD  - Department of General Surgery, Jiangxi Provincial Children's Hospital, Nanchang, 
      Jiangxi 330006, China.
FAU - Luo, Li
AU  - Luo L
AD  - Department of Respiratory, Jiangxi Provincial Children's Hospital, Nanchang, 
      Jiangxi 330006, China.
FAU - Hu, Meiying
AU  - Hu M
AD  - Pediatric Cardiology Center, Jiangxi Provincial Children's Hospital, Nanchang, 
      Jiangxi 330006, China.
FAU - Dong, Qi
AU  - Dong Q
AD  - Department of Respiratory, Jiangxi Provincial Children's Hospital, Nanchang, 
      Jiangxi 330006, China.
FAU - Hong, Liang
AU  - Hong L
AD  - Department of Respiratory, Jiangxi Provincial Children's Hospital, Nanchang, 
      Jiangxi 330006, China.
FAU - Zhang, Shouhua
AU  - Zhang S
AUID- ORCID: 0000-0002-8225-1350
AD  - Department of General Surgery, The Affiliated Children's Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, China.
FAU - Tao, Qiang
AU  - Tao Q
AUID- ORCID: 0000-0002-9234-2352
AD  - Department of General Surgery, Jiangxi Provincial Children's Hospital, Nanchang, 
      Jiangxi 330006, China.
AD  - Department of General Surgery, The Affiliated Children's Hospital of Nanchang 
      University, Nanchang, Jiangxi 330006, China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20210830
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Biomarkers)
SB  - IM
RIN - Dis Markers. 2023 Jun 21;2023:9892018. PMID: 37387765
MH  - Biomarkers/*analysis
MH  - China
MH  - Female
MH  - Hand, Foot and Mouth Disease/*diagnosis/epidemiology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Mental Disorders/*physiopathology
MH  - Prognosis
MH  - Respiratory Insufficiency/*physiopathology
MH  - Retrospective Studies
MH  - *Severity of Illness Index
PMC - PMC8423554
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/09/11 06:00
MHDA- 2022/01/27 06:00
PMCR- 2021/08/30
CRDT- 2021/09/10 07:00
PHST- 2021/05/03 00:00 [received]
PHST- 2021/08/16 00:00 [accepted]
PHST- 2021/09/10 07:00 [entrez]
PHST- 2021/09/11 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2021/08/30 00:00 [pmc-release]
AID - 10.1155/2021/1923636 [doi]
PST - epublish
SO  - Dis Markers. 2021 Aug 30;2021:1923636. doi: 10.1155/2021/1923636. eCollection 
      2021.