PMID- 34505233
OWN - NLM
STAT- MEDLINE
DCOM- 20220224
LR  - 20221207
IS  - 2520-8721 (Electronic)
IS  - 1109-3099 (Linking)
VI  - 20
IP  - 4
DP  - 2021 Dec
TI  - Vascular effects following intensification of glycemic control in poorly 
      controlled patients with long-standing type 2 diabetes mellitus.
PG  - 783-791
LID - 10.1007/s42000-021-00318-x [doi]
AB  - PURPOSE: The aim of the present study was to investigate the effect of intensive 
      antidiabetic therapy on vascular indices in type 2 diabetes mellitus (T2DM) 
      patients. METHODS: Poorly controlled T2DM patients (n = 62, mean age 64 years, 
      T2DM duration 14 years, HbA1c >/= 7.5%) were studied at baseline and following 
      intensive treatment to achieve optimal glycemic control. Brachial artery 
      flow-mediated dilation, carotid-femoral pulse wave velocity, central augmentation 
      index, large and small (C2) artery compliance, carotid intima-media thickness 
      (cIMT), and ankle-brachial index were assessed at baseline and follow-up. 
      RESULTS: HbA1c decreased from 8.8% (8.1, 10.1) (median, interquartile range-IQ) 
      to 7.4% (6.9, 7.8), p < 0.001. Triglycerides and high-sensitivity C-reactive 
      protein levels were decreased by ~ 10% and 50%, respectively (p < 0.05). Maximum 
      cIMT and C2 increased at follow-up (0.97 +/- 0.25 to 1.03 +/- 0.27 mm and 3.3 (2.7, 
      4.2) to 4.2 (3.2, 5.4) ml/mmHg x 10, respectively, p < 0.05). In subgroup 
      analysis, the observed changes in vascular indices were not affected by diabetes 
      duration, presence of cardiovascular disease, or insulin treatment. CONCLUSION: 
      In patients with long-standing T2DM, short-term aggressive glycemic control was 
      associated with an improvement of microvascular function (C2) and deterioration 
      of carotid atherosclerosis (IMT) without any effect on the elastic properties of 
      large arteries.
CI  - (c) 2021. Hellenic Endocrine Society.
FAU - Antoniou, Sofia
AU  - Antoniou S
AD  - Department of Endocrinology, University of Ioannina, 45110, Ioannina, Greece.
AD  - 2nd Department of Cardiology and Michaelidion Cardiac Center, University of 
      Ioannina, Ioannina, Greece.
FAU - Naka, Katerina K
AU  - Naka KK
AD  - 2nd Department of Cardiology and Michaelidion Cardiac Center, University of 
      Ioannina, Ioannina, Greece.
FAU - Bechlioulis, Aris
AU  - Bechlioulis A
AD  - 2nd Department of Cardiology and Michaelidion Cardiac Center, University of 
      Ioannina, Ioannina, Greece.
FAU - Papadakis, Marios
AU  - Papadakis M
AD  - Department of Surgery II, University Witten-Herdecke, Witten, Germany.
FAU - Tsatsoulis, Agathocles
AU  - Tsatsoulis A
AD  - Department of Endocrinology, University of Ioannina, 45110, Ioannina, Greece.
FAU - Michalis, Lampros K
AU  - Michalis LK
AD  - 2nd Department of Cardiology and Michaelidion Cardiac Center, University of 
      Ioannina, Ioannina, Greece.
FAU - Tigas, Stelios
AU  - Tigas S
AUID- ORCID: 0000-0001-7325-8983
AD  - Department of Endocrinology, University of Ioannina, 45110, Ioannina, Greece. 
      stigas@uoi.gr.
LA  - eng
PT  - Journal Article
DEP - 20210909
PL  - Switzerland
TA  - Hormones (Athens)
JT  - Hormones (Athens, Greece)
JID - 101142469
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
MH  - Carotid Intima-Media Thickness
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Glycated Hemoglobin/metabolism
MH  - Glycemic Control/methods
MH  - Humans
MH  - Middle Aged
MH  - Pulse Wave Analysis
OTO - NOTNLM
OT  - Arterial stiffness
OT  - Carotid intima-media thickness
OT  - Diabetes mellitus
OT  - Endothelial function
OT  - HbA1c
OT  - Intensive glycemic control
EDAT- 2021/09/11 06:00
MHDA- 2022/02/25 06:00
CRDT- 2021/09/10 07:12
PHST- 2021/03/09 00:00 [received]
PHST- 2021/08/30 00:00 [accepted]
PHST- 2021/09/11 06:00 [pubmed]
PHST- 2022/02/25 06:00 [medline]
PHST- 2021/09/10 07:12 [entrez]
AID - 10.1007/s42000-021-00318-x [pii]
AID - 10.1007/s42000-021-00318-x [doi]
PST - ppublish
SO  - Hormones (Athens). 2021 Dec;20(4):783-791. doi: 10.1007/s42000-021-00318-x. Epub 
      2021 Sep 9.