PMID- 34505615
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 12
IP  - 20
DP  - 2021 Oct 19
TI  - Hypoglycemic effects of Auricularia auricula polysaccharides on high fat diet and 
      streptozotocin-induced diabetic mice using metabolomics analysis.
PG  - 9994-10007
LID - 10.1039/d1fo02022f [doi]
AB  - This study evaluated the hypoglycemic effect of Auricularia auricula 
      polysaccharides (AAPs) on streptozotocin-induced type 2 diabetes mellitus (T2DM) 
      mice using metabolomic analysis. The results of fasting blood glucose, oral 
      glucose tolerance test, fasting serum insulin level, Homeostatic Model Assessment 
      of Insulin Resistance index, TC, TG, HDL-C, LDL-C, and histopathological 
      observation demonstrated that 200 mg per kg body weight per day AAP led to 
      significant hypoglycemic activities. The metabolic profile of the mice was 
      significantly changed after AAP intervention. 45 differential metabolites were 
      screened as biomarkers for AAP adjuvant treatment, and AAPs' effects on the 
      metabolism of amino acids, unsaturated fatty acids, bile acids, and 
      glycerophospholipids were analyzed. Thus, the current results elucidated the 
      metabolic pathway of AAPs for T2DM alleviation and provided guidance for 
      functional food adjuvant development for T2DM treatment.
FAU - Liu, Nannan
AU  - Liu N
AUID- ORCID: 0000-0002-9324-376X
AD  - School of Food and Biological Engineering, Shaanxi University of Science and 
      Technology, Xi'an 710021, China. chenxf201693@163.com.
AD  - College of Chemistry and Materials Science, Weinan Normal University, Weinan 
      714000, China.
FAU - Chen, Xuefeng
AU  - Chen X
AD  - School of Food and Biological Engineering, Shaanxi University of Science and 
      Technology, Xi'an 710021, China. chenxf201693@163.com.
FAU - Song, Juanna
AU  - Song J
AD  - School of Food and Biological Engineering, Shaanxi University of Science and 
      Technology, Xi'an 710021, China. chenxf201693@163.com.
FAU - Chen, Mengyin
AU  - Chen M
AD  - School of Food and Biological Engineering, Shaanxi University of Science and 
      Technology, Xi'an 710021, China. chenxf201693@163.com.
FAU - Gong, Pin
AU  - Gong P
AD  - School of Food and Biological Engineering, Shaanxi University of Science and 
      Technology, Xi'an 710021, China. chenxf201693@163.com.
FAU - Jia, Wei
AU  - Jia W
AD  - School of Food and Biological Engineering, Shaanxi University of Science and 
      Technology, Xi'an 710021, China. chenxf201693@163.com.
FAU - Li, Guoliang
AU  - Li G
AD  - School of Food and Biological Engineering, Shaanxi University of Science and 
      Technology, Xi'an 710021, China. chenxf201693@163.com.
LA  - eng
PT  - Journal Article
DEP - 20211019
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Blood Glucose)
RN  - 0 (Fungal Polysaccharides)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
RN  - 5W494URQ81 (Streptozocin)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - Auricularia auricula-judae
SB  - IM
MH  - Animals
MH  - Auricularia/*chemistry
MH  - Blood Glucose/analysis
MH  - Cholesterol/blood
MH  - Diabetes Mellitus, Experimental/*drug therapy/metabolism
MH  - Diabetes Mellitus, Type 2/*drug therapy/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Fungal Polysaccharides/*pharmacology
MH  - Hypoglycemic Agents/*pharmacology
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Male
MH  - Metabolome
MH  - Metabolomics/*methods
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Streptozocin/adverse effects
EDAT- 2021/09/11 06:00
MHDA- 2022/02/01 06:00
CRDT- 2021/09/10 08:39
PHST- 2021/09/11 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/09/10 08:39 [entrez]
AID - 10.1039/d1fo02022f [doi]
PST - epublish
SO  - Food Funct. 2021 Oct 19;12(20):9994-10007. doi: 10.1039/d1fo02022f.