PMID- 34507015
OWN - NLM
STAT- MEDLINE
DCOM- 20220107
LR  - 20220107
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 360
DP  - 2021 Nov 15
TI  - Elevated mycobacterium avium subsp. paratuberculosis (MAP) antibody titer in 
      Japanese multiple sclerosis.
PG  - 577701
LID - S0165-5728(21)00228-9 [pii]
LID - 10.1016/j.jneuroim.2021.577701 [doi]
AB  - To investigate whether antibody production against mycobacterium avium subsp. 
      paratuberculosis (MAP) is related to clinical characteristics of multiple 
      sclerosis (MS) and human leukocyte antigen (HLA) alleles, IgG antibody against 
      three MAP peptides and two human peptides homologous to MAP were measured in sera 
      from 103 MS patients and 50 healthy controls (HCs). MS patients had higher IgG 
      levels against MAP2694(295-303) (MAP2694-IgG) than HCs, while the other 
      antibodies were comparable. Multivariate analysis demonstrated that higher 
      MAP2694-IgG titers were associated with higher EDSS scores, but not with HLA 
      alleles or dairy product consumption. Immune response against MAP may worsen MS 
      disability.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Hayashi, Fumie
AU  - Hayashi F
AD  - Department of Neurology, Graduate School of Medical Sciences, Kyushu University, 
      Fukuoka, Japan.
FAU - Isobe, Noriko
AU  - Isobe N
AD  - Department of Neurology, Graduate School of Medical Sciences, Kyushu University, 
      Fukuoka, Japan.
FAU - Cossu, Davide
AU  - Cossu D
AD  - Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan; 
      Department of Biomedical Sciences, Division of Microbiology and Virology, 
      University of Sassari, Italy.
FAU - Yokoyama, Kazumasa
AU  - Yokoyama K
AD  - Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
FAU - Sakoda, Ayako
AU  - Sakoda A
AD  - Department of Neurology, Graduate School of Medical Sciences, Kyushu University, 
      Fukuoka, Japan; Department of Neurology, Brain and Nerve Center, Fukuoka Central 
      Hospital, International University of Health and Welfare, Fukuoka, Japan.
FAU - Matsushita, Takuya
AU  - Matsushita T
AD  - Department of Neurology, Graduate School of Medical Sciences, Kyushu University, 
      Fukuoka, Japan.
FAU - Hattori, Nobutaka
AU  - Hattori N
AD  - Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
FAU - Kira, Jun-Ichi
AU  - Kira JI
AD  - Department of Neurology, Graduate School of Medical Sciences, Kyushu University, 
      Fukuoka, Japan; Department of Neurology, Brain and Nerve Center, Fukuoka Central 
      Hospital, International University of Health and Welfare, Fukuoka, Japan; 
      Translational Neuroscience Center, Graduate School of Medicine, School of 
      Pharmacy at Fukuoka, International University of Health and Welfare, Fukuoka, 
      Japan. Electronic address: kira@neuro.med.kyushu-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210825
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Bacterial Proteins)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (IRF5 protein, human)
RN  - 0 (Immunodominant Epitopes)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Interferon Regulatory Factors)
RN  - 0 (Membrane Proteins)
RN  - 0 (Myelin Basic Protein)
RN  - 0 (Oligoclonal Bands)
RN  - 0 (Peptide Fragments)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Bacterial/*blood
MH  - Antibody Specificity
MH  - Antigens, Bacterial/immunology
MH  - Bacterial Proteins/chemistry/immunology
MH  - Dairy Products
MH  - Diet
MH  - Female
MH  - Genes, MHC Class II
MH  - HLA-DRB1 Chains/genetics
MH  - Humans
MH  - Immunodominant Epitopes/immunology
MH  - Immunoglobulin G/*blood/immunology
MH  - Interferon Regulatory Factors/immunology
MH  - Japan/epidemiology
MH  - Male
MH  - Membrane Proteins/chemistry/immunology
MH  - Middle Aged
MH  - Molecular Mimicry
MH  - Multiple Sclerosis/cerebrospinal fluid/epidemiology/genetics/*immunology
MH  - Mycobacterium avium subsp. paratuberculosis/*immunology
MH  - Myelin Basic Protein/immunology
MH  - Oligoclonal Bands/cerebrospinal fluid
MH  - Peptide Fragments/immunology
MH  - Receptors, Antigen, T-Cell, alpha-beta/immunology
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Expanded disability status scale
OT  - Multiple sclerosis
OT  - Mycobacterium avium subsp. paratuberculosis
EDAT- 2021/09/11 06:00
MHDA- 2022/01/08 06:00
CRDT- 2021/09/10 20:16
PHST- 2021/05/17 00:00 [received]
PHST- 2021/08/07 00:00 [revised]
PHST- 2021/08/22 00:00 [accepted]
PHST- 2021/09/11 06:00 [pubmed]
PHST- 2022/01/08 06:00 [medline]
PHST- 2021/09/10 20:16 [entrez]
AID - S0165-5728(21)00228-9 [pii]
AID - 10.1016/j.jneuroim.2021.577701 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2021 Nov 15;360:577701. doi: 10.1016/j.jneuroim.2021.577701. Epub 
      2021 Aug 25.