PMID- 34507878
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20221207
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 36
IP  - 1
DP  - 2022 Jan
TI  - Incidence of diabetic retinopathy in newly diagnosed subjects with type 2 
      diabetes mellitus over 5 years: Contribution of Beta-cell function.
PG  - 108028
LID - S1056-8727(21)00237-3 [pii]
LID - 10.1016/j.jdiacomp.2021.108028 [doi]
AB  - AIMS: Identifying and modulating risk factors is essential to prevent visual 
      impairment due to diabetic retinopathy (DR). This study examines incident DR with 
      metabolic and hormonal factors in newly-diagnosed, treatment naive, individuals 
      with Type2 Diabetes Mellitus (T2DM), over a 5 year period from diagnosis. 
      METHODS: 233 T2DM subjects underwent serial DR screening using digital 
      photography and standardised Meal Tolerance Tests at diagnosis and after 1, 2 and 
      5 years. Subjects (179) with no DR throughout the 5-year study period were 
      compared with those who developed DR (54). RESULTS: Of 233 subjects, 54(23.2%) 
      developed DR by 5 years, background DR in 50(93%) and exudative maculopathy in 
      4(7%) individuals. Of these subjects, 12(22%) developed DR after 1 year, 15(28%) 
      after 2 years and 27(50%) after 5 years. At baseline, those with DR at 5 years 
      had higher HbA(1c) (p = 0.017), higher fasting plasma glucose (PG) (p = 0.031) 
      and postprandial PG (p = 0.009). They were associated with reduced basal beta-cell 
      secretory function (M(0)) (p = 0.025), lower (p = 0.000) postprandial beta-cell 
      responsiveness (M(1)) and beta-cell function (HOMA-B) (p = 0.044). CONCLUSIONS: 
      There is an independent association between glycaemic control and beta-cell 
      dysfunction at the time of diagnosis of T2DM, with incident DR over a follow-up 
      period of 5 years.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Roy Chowdhury, Sharmistha
AU  - Roy Chowdhury S
AD  - Department of Diabetes and Endocrinology, Princess of Wales Hospital, Bridgend 
      CF31 1RQ, UK. Electronic address: sharmistha.roychowdhury@wales.nhs.uk.
FAU - Thomas, Rebecca L
AU  - Thomas RL
AD  - Diabetes Research Group, Swansea University, Singleton Park, Swansea SA2 8PP, UK.
FAU - Dunseath, Gareth J
AU  - Dunseath GJ
AD  - Diabetes Research Group, Swansea University, Singleton Park, Swansea SA2 8PP, UK.
FAU - Luzio, Stephen D
AU  - Luzio SD
AD  - Diabetes Research Group, Swansea University, Singleton Park, Swansea SA2 8PP, UK.
FAU - Wong, F Susan
AU  - Wong FS
AD  - Diabetes Research Group, Division of Infection and Immunity, Cardiff University 
      School of Medicine, Cardiff CF14 4XN, UK.
FAU - Owens, David R
AU  - Owens DR
AD  - Diabetes Research Group, Swansea University, Singleton Park, Swansea SA2 8PP, UK.
LA  - eng
PT  - Journal Article
DEP - 20210830
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Glycated Hemoglobin A)
SB  - IM
CIN - J Diabetes Complications. 2022 Jan;36(1):108045. PMID: 34802901
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - *Diabetic Retinopathy/diagnosis/epidemiology/etiology
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Incidence
MH  - *Insulin-Secreting Cells/metabolism
MH  - Risk Factors
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - Fasting and postprandial hyperglycaemia
OT  - Insulin sensitivity/resistance
OT  - Pancreatic beta-cell function
EDAT- 2021/09/12 06:00
MHDA- 2022/03/15 06:00
CRDT- 2021/09/11 05:30
PHST- 2021/02/27 00:00 [received]
PHST- 2021/08/15 00:00 [revised]
PHST- 2021/08/17 00:00 [accepted]
PHST- 2021/09/12 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2021/09/11 05:30 [entrez]
AID - S1056-8727(21)00237-3 [pii]
AID - 10.1016/j.jdiacomp.2021.108028 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2022 Jan;36(1):108028. doi: 
      10.1016/j.jdiacomp.2021.108028. Epub 2021 Aug 30.