PMID- 34510202
OWN - NLM
STAT- MEDLINE
DCOM- 20220323
LR  - 20220323
IS  - 1524-4040 (Electronic)
IS  - 0148-396X (Linking)
VI  - 89
IP  - 6
DP  - 2021 Nov 18
TI  - Lateral Thoracolumbar Listhesis as an Independent Predictor of Disability in 
      Adult Scoliosis Patients: Multivariable Assessment Before and After Surgical 
      Realignment.
PG  - 1080-1086
LID - 10.1093/neuros/nyab356 [doi]
AB  - BACKGROUND: Lateral (ie, coronal) vertebral listhesis may contribute to 
      disability in adult scoliosis patients. OBJECTIVE: To assess for a correlation 
      between lateral listhesis and disability among patients with adult scoliosis. 
      METHODS: This was a retrospective multi-center analysis of prospectively 
      collected data. Patients eligible for a minimum of 2-yr follow-up and with 
      coronal plane deformity (defined as maximum Cobb angle >/=20 masculine) were included 
      (n = 724). Outcome measures were Oswestry Disability Index (ODI) and leg pain 
      numeric scale rating. Lateral thoracolumbar listhesis was measured as the maximum 
      vertebral listhesis as a percent of the superior endplate across T1-L5 levels. 
      Linear and logistic regression was utilized, as appropriate. Multivariable 
      analyses adjusted for demographics, comorbidities, surgical invasiveness, maximum 
      Cobb angle, and T1-PA. Minimally clinically important difference (MCID) in ODI 
      was defined as 12.8. RESULTS: In total, 724 adult patients were assessed. The 
      mean baseline maximum lateral thoracolumbar listhesis was 18.3% (standard 
      deviation 9.7%). The optimal statistical grouping for lateral listhesis was 
      empirically determined to be none/mild (<6.7%), moderate (6.7-15.4%), and severe 
      (>/=15.4%). In multivariable analysis, listhesis of moderate and severe vs 
      none/mild was associated with worse baseline ODI (none/mild = 33.7; 
      moderate = 41.6; severe = 43.9; P < .001 for both comparisons) and leg pain NSR 
      (none/mild = 2.9, moderate = 4.0, severe = 5.1, P < .05). Resolution of severe 
      lateral listhesis to none/mild was independently associated with increased 
      likelihood of reaching MCID in ODI at 2 yr postoperatively (odds ratio 2.1 95% 
      confidence interval 1.2-3.7, P = .0097). CONCLUSION: Lateral thoracolumbar 
      listhesis is associated with worse baseline disability among adult scoliosis 
      patients. Resolution of severe lateral listhesis following deformity correction 
      was independently associated with increased likelihood of reaching MCID in ODI at 
      2-yr follow-up.
CI  - (c) Congress of Neurological Surgeons 2021.
FAU - Daniels, Alan H
AU  - Daniels AH
AD  - Department of Orthopedics, Warren Alpert Medical School of Brown University, East 
      Providence, Rhode Island, USA.
FAU - Durand, Wesley M
AU  - Durand WM
AD  - Department of Orthopedics, Johns Hopkins University, Baltimore, Maryland, USA.
FAU - Lafage, Renaud
AU  - Lafage R
AD  - Hospital for Special Surgery, New York, New York, USA.
FAU - Zhang, Andrew S
AU  - Zhang AS
AD  - Department of Orthopedics, Warren Alpert Medical School of Brown University, East 
      Providence, Rhode Island, USA.
FAU - Hamilton, David K
AU  - Hamilton DK
AD  - University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
FAU - Passias, Peter G
AU  - Passias PG
AD  - Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, New York, 
      USA.
FAU - Kim, Han Jo
AU  - Kim HJ
AD  - Hospital for Special Surgery, New York, New York, USA.
FAU - Protopsaltis, Themistocles
AU  - Protopsaltis T
AD  - Department of Orthopedics, NYU Langone Orthopedic Hospital, New York, New York, 
      USA.
FAU - Lafage, Virginie
AU  - Lafage V
AD  - Hospital for Special Surgery, New York, New York, USA.
FAU - Smith, Justin S
AU  - Smith JS
AD  - University of Virginia Health System, Charlottesville, Virginia, USA.
FAU - Shaffrey, Christopher
AU  - Shaffrey C
AUID- ORCID: 0000-0001-9760-8386
AD  - Duke University, Durham, North Carolina, USA.
FAU - Gupta, Munish
AU  - Gupta M
AD  - Washington University, St. Louis, Missouri, USA.
FAU - Klineberg, Eric
AU  - Klineberg E
AD  - University of California-Davis, Sacramento, California, USA.
FAU - Schwab, Frank
AU  - Schwab F
AD  - Hospital for Special Surgery, New York, New York, USA.
FAU - Burton, Doug
AU  - Burton D
AD  - University of Kansas Hospital, Kansas City, Kansas, USA.
FAU - Bess, Shay
AU  - Bess S
AD  - Denver International Spine Center, Denver, Colorado, USA.
FAU - Ames, Christopher
AU  - Ames C
AD  - University of California-San Francisco, California, USA.
FAU - Hart, Robert A
AU  - Hart RA
AD  - Swedish Neuroscience Institute, Seattle, Washington, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurosurgery
JT  - Neurosurgery
JID - 7802914
SB  - IM
CIN - Neurosurgery. 2022 Jan 1;90(1):e17-e18. PMID: 34982890
MH  - Adult
MH  - Disability Evaluation
MH  - Humans
MH  - Pain
MH  - Pain Measurement
MH  - Quality of Life
MH  - Retrospective Studies
MH  - *Scoliosis/complications/surgery
MH  - Spine/surgery
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Adult spinal deformity
OT  - HRQOL
OT  - Lateral thoracolumbar listhesis
OT  - ODI
EDAT- 2021/09/13 06:00
MHDA- 2022/03/24 06:00
CRDT- 2021/09/12 21:08
PHST- 2021/04/08 00:00 [received]
PHST- 2021/07/31 00:00 [accepted]
PHST- 2021/09/13 06:00 [pubmed]
PHST- 2022/03/24 06:00 [medline]
PHST- 2021/09/12 21:08 [entrez]
AID - 6369078 [pii]
AID - 10.1093/neuros/nyab356 [doi]
PST - ppublish
SO  - Neurosurgery. 2021 Nov 18;89(6):1080-1086. doi: 10.1093/neuros/nyab356.