PMID- 34510392
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211009
IS  - 1869-6953 (Print)
IS  - 1869-6961 (Electronic)
IS  - 1869-6961 (Linking)
VI  - 12
IP  - 10
DP  - 2021 Oct
TI  - The Therapeutic Effects of Mild to Moderate Intensity Aerobic Exercise on 
      Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of 
      Randomized Trials.
PG  - 2767-2781
LID - 10.1007/s13300-021-01149-0 [doi]
AB  - INTRODUCTION: It has been recommended that physical activity be a part of 
      treatment and management regimens of type 2 diabetes mellitus (T2DM), and 
      research has shown that regular physical exercise facilitates glycemic control in 
      these patients. In this analysis, our aim was to systematically show the 
      therapeutic effects of mild to moderate intensity aerobic exercise on glycemic 
      control in patients with T2DM. METHODS: From February to April 2021, we searched 
      the https://www.clinicaltrials.gov , EMBASE, MEDLINE, Cochrane Central Register 
      of Controlled Trials (CENTRAL), Web of Science and Google Scholar databases for 
      trials that showed the effects of aerobic exercise on glycemic control in 
      patients with T2DM. Glycated hemoglobin (HbA1c) was the endpoint in the analysis. 
      The RevMan version 5.4 statistical program was used for statistical analysis, and 
      the mean difference (MD) and 95% confidence intervals (CI) used to represent the 
      data following analysis. RESULTS: Eighteen trials involving 972 participants with 
      T2DM were included in this meta-analysis, of whom 523 were assigned to an 
      exercise group and 449 were assigned to a control group. A comparison pre- versus 
      post-aerobic exercise showed that aerobic exercise significantly improved 
      glycemic control (HbA1c) (MD 0.35, 95% CI 0.23-0.48; P = 0.00001) in these 
      patients with T2DM. A second comparison, T2DM participants in the experimental 
      group post-exercise versus T2DM participants from the control group at the end of 
      the follow-up, also showed that aerobic exercise significantly improved glycemic 
      control (MD - 0.46, 95% CI - 0.69 to - 0.22; P = 0.0001). However, a comparison 
      of HbA1c of T2DM participants in the control group at the beginning of the study 
      compared to those at the end of follow-up did not show any significant 
      improvement in glycemic control (MD 0.08, 95% CI - 0.05 to 0.21; P = 0.21). 
      CONCLUSION: The current analysis showed that mild to moderate intensity aerobic 
      exercise significantly improved glycemic control in patients with T2DM. Patients 
      with T2DM who regularly participated in aerobic exercise activities had a better 
      control of their disease than those who were not on a regular aerobic exercise 
      regimen. These results lead to the recommendation that at least mild to moderate 
      intensity aerobic exercise should be included in the treatment and management 
      regimens of patients with T2DM.
CI  - (c) 2021. The Author(s).
FAU - Gao, Siyao
AU  - Gao S
AD  - Department of Physical Education, Central South University, Changsha, 410083, 
      Hunan, People's Republic of China.
FAU - Tang, Jialing
AU  - Tang J
AD  - Department of Physical Education, Central South University, Changsha, 410083, 
      Hunan, People's Republic of China. siyaog@163.com.
FAU - Yi, Guozhong
AU  - Yi G
AD  - Department of Physical Education, Central South University, Changsha, 410083, 
      Hunan, People's Republic of China.
FAU - Li, Zhong
AU  - Li Z
AD  - Department of Physical Education, Central South University, Changsha, 410083, 
      Hunan, People's Republic of China.
FAU - Chen, Zhenyin
AU  - Chen Z
AD  - Department of Physical Education, Central South University, Changsha, 410083, 
      Hunan, People's Republic of China.
FAU - Yu, Ling
AU  - Yu L
AD  - Department of Physical Education, Central South University, Changsha, 410083, 
      Hunan, People's Republic of China.
FAU - Zheng, Feng
AU  - Zheng F
AD  - Department of Physical Education, Central South University, Changsha, 410083, 
      Hunan, People's Republic of China.
FAU - Hu, Yajing
AU  - Hu Y
AD  - Department of Physical Education, Central South University, Changsha, 410083, 
      Hunan, People's Republic of China.
FAU - Tang, Zhangui
AU  - Tang Z
AD  - Department of Cardiovascular Disease, Zhejiang University Medical College 
      Teaching Hospital, Zhejiang, Hangzhou, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20210912
PL  - United States
TA  - Diabetes Ther
JT  - Diabetes therapy : research, treatment and education of diabetes and related 
      disorders
JID - 101539025
PMC - PMC8479032
OTO - NOTNLM
OT  - Aerobic exercise
OT  - Glycemic control
OT  - Glycosylated hemoglobin
OT  - Type 2 diabetes mellitus
EDAT- 2021/09/13 06:00
MHDA- 2021/09/13 06:01
PMCR- 2021/09/12
CRDT- 2021/09/12 21:13
PHST- 2021/08/05 00:00 [received]
PHST- 2021/08/25 00:00 [accepted]
PHST- 2021/09/13 06:00 [pubmed]
PHST- 2021/09/13 06:01 [medline]
PHST- 2021/09/12 21:13 [entrez]
PHST- 2021/09/12 00:00 [pmc-release]
AID - 10.1007/s13300-021-01149-0 [pii]
AID - 1149 [pii]
AID - 10.1007/s13300-021-01149-0 [doi]
PST - ppublish
SO  - Diabetes Ther. 2021 Oct;12(10):2767-2781. doi: 10.1007/s13300-021-01149-0. Epub 
      2021 Sep 12.