PMID- 34510598
OWN - NLM
STAT- MEDLINE
DCOM- 20220203
LR  - 20220203
IS  - 1521-4095 (Electronic)
IS  - 0935-9648 (Linking)
VI  - 33
IP  - 43
DP  - 2021 Oct
TI  - A Novel Immunomodulator Delivery Platform Based on Bacterial Biomimetic Vesicles 
      for Enhanced Antitumor Immunity.
PG  - e2103923
LID - 10.1002/adma.202103923 [doi]
AB  - T cell activation-induced cell death (AICD) during tumor pathogenesis is a tumor 
      immune escape process dependent on dendritic cells (DCs). Proper 
      immune-modulatory therapies effectively inhibit tumor-specific CD8(+) T cell 
      exhaustion and enhance antitumor immune responses. Here, high-pressure 
      homogenization is utilized to drive immunomodulator IL10-modified bacteria to 
      extrude through the gap and self-assemble into bacterial biomimetic vesicles 
      exposing IL10 (IL10-BBVs) on the surface with high efficiency. IL10-BBVs 
      efficiently target DCs in tumor-draining lymph nodes and thus increase the 
      interaction between IL10 on BBVs and IL10R on DCs to suppress AICD and mitigate 
      CD8(+) T cell exhaustion specific to tumor antigens. Two subcutaneous peripheral 
      injections of IL10-BBVs 1 week apart in tumor-bearing mice effectively increase 
      systemic and intratumoral proportions of CD8(+) T cells to suppress tumor growth 
      and metastasis. Tumor-specific antigen E7 is enclosed into the periplasm of 
      IL10-BBVs (IL10-E7-BBVs) to realize concurrent actions of the immunomodulator 
      IL10 and the tumor antigen human papillomavirus (HPV) 16E7 in lymph nodes, 
      further enhancing the antitumor effects mediated by CD8(+) T cells. The 
      development of this modified BBV delivery platform will expand the application of 
      bacterial membranes and provide novel immunotherapeutic strategies for tumor 
      treatment.
CI  - (c) 2021 Wiley-VCH GmbH.
FAU - Hua, Liangqun
AU  - Hua L
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
AD  - School of Life Sciences, Yunnan University, 2 Cuihu North Road, Kunming, 650091, 
      China.
FAU - Yang, Zhongqian
AU  - Yang Z
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
FAU - Li, Weiran
AU  - Li W
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
FAU - Zhang, Qishu
AU  - Zhang Q
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
FAU - Ren, Zhaoling
AU  - Ren Z
AD  - The Second Affiliated Hospital of Kunming Medical University, 374 Dian Burma 
      Avenue, Kunming, 650101, China.
FAU - Ye, Chao
AU  - Ye C
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
FAU - Zheng, Xiao
AU  - Zheng X
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
AD  - School of Life Sciences, Yunnan University, 2 Cuihu North Road, Kunming, 650091, 
      China.
FAU - Li, Duo
AU  - Li D
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
AD  - Department of Acute Infectious Diseases Control and Prevention, Yunnan Provincial 
      Center for Disease Control and Prevention, 158 Dongsi Street, Kunming, 530112, 
      China.
FAU - Long, Qiong
AU  - Long Q
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
FAU - Bai, Hongmei
AU  - Bai H
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
FAU - Sun, Wenjia
AU  - Sun W
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
FAU - Yang, Xu
AU  - Yang X
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
FAU - Zheng, Peng
AU  - Zheng P
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
FAU - He, Jinrong
AU  - He J
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
AD  - Kunming Medical University, 1168 Chunrong West Road, Kunming, 650500, China.
FAU - Chen, Yongjun
AU  - Chen Y
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
FAU - Huang, Weiwei
AU  - Huang W
AUID- ORCID: 0000-0001-6417-3785
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
FAU - Ma, Yanbing
AU  - Ma Y
AD  - Laboratory of Molecular Immunology, Institute of Medical Biology, Chinese Academy 
      of Medical Sciences and Peking Union Medical College, 935 Jiaoling Road, Kunming, 
      650118, China.
LA  - eng
GR  - 3332020063/Fundamental Research Funds for the Central Universities and PUMC Youth 
      Fund/
GR  - 2019FB045/Science and Technology Project of Yunnan Province/
GR  - 202105AC160019/Science and Technology Project of Yunnan Province/
GR  - 202002AA100009/Science and Technology Project of Yunnan Province/
GR  - 2016FA049/Science and Technology Project of Yunnan Province/
GR  - 81773270/National Natural Science Foundation of China/
GR  - H-2018069/Yunnan High-level Health and Technical Personnel Project/
GR  - 2020-I2M-2-014/CAMS Initiative for Innovative Medicine/
PT  - Journal Article
DEP - 20210912
PL  - Germany
TA  - Adv Mater
JT  - Advanced materials (Deerfield Beach, Fla.)
JID - 9885358
SB  - IM
MH  - *Biomimetics
OTO - NOTNLM
OT  - activation-induced T cell death
OT  - antitumor immunity
OT  - bacterial vesicles
OT  - cytokines
OT  - immunomodulators
EDAT- 2021/09/13 06:00
MHDA- 2022/02/04 06:00
CRDT- 2021/09/12 21:25
PHST- 2021/07/06 00:00 [revised]
PHST- 2021/05/24 00:00 [received]
PHST- 2021/09/13 06:00 [pubmed]
PHST- 2022/02/04 06:00 [medline]
PHST- 2021/09/12 21:25 [entrez]
AID - 10.1002/adma.202103923 [doi]
PST - ppublish
SO  - Adv Mater. 2021 Oct;33(43):e2103923. doi: 10.1002/adma.202103923. Epub 2021 Sep 
      12.