PMID- 34511177
OWN - NLM
STAT- MEDLINE
DCOM- 20210914
LR  - 20231102
IS  - 1008-8830 (Print)
IS  - 1008-8830 (Linking)
VI  - 23
IP  - 8
DP  - 2021 Aug 15
TI  - Research advances on haploidentical hematopoietic stem cell transplantation in 
      the treatment of severe aplastic anemia in children.
PG  - 854-859
LID - 1008-8830(2021)08-0854-06 [pii]
LID - 10.7499/j.issn.1008-8830.2105073 [doi]
AB  - Haploidentical hematopoietic stem cell transplantation is a recommended 
      alternative therapy for children with severe aplastic anemia who lack a human 
      leukocyte antigen (HLA)-identical sibling donor and do not respond well to 
      immunosuppressive therapy; however, due to non-identical HLA, the patients may 
      have donor-specific anti-HLA antibody, which may lead to a relatively high 
      incidence rate of poor graft function. Compared with HLA-identical 
      transplantation, conditioning regimen for haploidentical transplantation still 
      needs to be explored. This article reviews the detection and treatment of 
      donor-specific anti-HLA antibody, the selection of conditioning regimen, and the 
      mechanism and treatment of poor graft function in haploidentical hematopoietic 
      stem cell transplantation.
FAU - Gao, Yang-Yang
AU  - Gao YY
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, 
      Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 
      300020, China.
FAU - Chen, Xiao-Juan
AU  - Chen XJ
AD  - State Key Laboratory of Experimental Hematology, National Clinical Research 
      Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, 
      Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 
      300020, China.
FAU - Luo, Rong-Mu
AU  - Luo RM
LA  - eng
LA  - chi
PT  - Journal Article
PT  - Review
TT  - 单倍体造血干细胞移植治疗儿童重型再生障碍性贫血的研究进展.
PL  - China
TA  - Zhongguo Dang Dai Er Ke Za Zhi
JT  - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
JID - 100909956
SB  - IM
MH  - *Anemia, Aplastic/therapy
MH  - Child
MH  - *Graft vs Host Disease
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Transplantation Conditioning
MH  - Transplantation, Homologous
PMC - PMC8428919
OAB - Haploidentical hematopoietic stem cell transplantation is a recommended 
      alternative therapy for children with severe aplastic anemia who lack a human 
      leukocyte antigen (HLA)-identical sibling donor and do not respond well to 
      immunosuppressive therapy; however, due to non-identical HLA, the patients may 
      have donor-specific anti-HLA antibody, which may lead to a relatively high 
      incidence rate of poor graft function. Compared with HLA-identical 
      transplantation, conditioning regimen for haploidentical transplantation still 
      needs to be explored. This article reviews the detection and treatment of 
      donor-specific anti-HLA antibody, the selection of conditioning regimen, and the 
      mechanism and treatment of poor graft function in haploidentical hematopoietic 
      stem cell transplantation.
OABL- eng
OTO - NOTNLM
OT  - Child
OT  - Conditioning regimen
OT  - Donor-specific anti-HLA antibody
OT  - Haploidentical hematopoietic stem cell transplantation
OT  - Poor graft function
OT  - Severe aplastic anemia
EDAT- 2021/09/14 06:00
MHDA- 2021/09/15 06:00
PMCR- 2021/08/15
CRDT- 2021/09/13 05:43
PHST- 2021/09/13 05:43 [entrez]
PHST- 2021/09/14 06:00 [pubmed]
PHST- 2021/09/15 06:00 [medline]
PHST- 2021/08/15 00:00 [pmc-release]
AID - 1008-8830(2021)08-0854-06 [pii]
AID - 10.7499/j.issn.1008-8830.2105073 [doi]
PST - ppublish
SO  - Zhongguo Dang Dai Er Ke Za Zhi. 2021 Aug 15;23(8):854-859. doi: 
      10.7499/j.issn.1008-8830.2105073.