PMID- 34511301
OWN - NLM
STAT- MEDLINE
DCOM- 20220711
LR  - 20220719
IS  - 1879-1476 (Electronic)
IS  - 0385-8146 (Linking)
VI  - 49
IP  - 6
DP  - 2022 Dec
TI  - Psychophysical assessments of olfaction after endoscopic unilateral resection 
      with post-operative radiotherapy in olfactory neuroblastomas.
PG  - 1088-1092
LID - S0385-8146(21)00230-3 [pii]
LID - 10.1016/j.anl.2021.08.007 [doi]
AB  - Endoscopic resection with post-operative radiotherapy has been included in the 
      standard therapeutic options for olfactory neuroblastomas (ONBs). Recent 
      publications have indicated the feasibility of olfactory preservation after 
      endoscopic unilateral resection of ONBs. This study validated residual olfaction 
      using the psychophysical assessment, T & T olfactometer, in patients who 
      underwent endoscopic unilateral resection with post-operative radiotherapy. A 
      single-institutional retrospective review was performed to identify patients who 
      underwent endoscopic unilateral resection of ONBs with olfaction monitoring using 
      T & T olfactometer between 2009 and 2020. T & T olfactometry was performed before 
      surgery, after surgery, before radiotherapy, and after completion of 
      radiotherapy. Four patients (one female and three males) were identified. The 
      mean observation period was 41.9 months, and all patients showed no evidence of 
      disease. Three patients exhibited residual olfactory function with two patients 
      having normal or pre-operative level olfaction, although T & T olfactometer 
      results showed a temporary increase in recognition thresholds after surgery. As 
      consequence, endoscopic unilateral resection can achieve satisfactory olfactory 
      preservation in patients with early-stage ONBs.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Matsunaga, Mami
AU  - Matsunaga M
AD  - Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
FAU - Kikuchi, Masahiro
AU  - Kikuchi M
AD  - Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
FAU - Kuwata, Fumihiko
AU  - Kuwata F
AD  - Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
FAU - Kitada, Yuji
AU  - Kitada Y
AD  - Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
FAU - Omori, Koichi
AU  - Omori K
AD  - Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
FAU - Nakagawa, Takayuki
AU  - Nakagawa T
AD  - Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, 
      Kyoto University, Kyoto, Japan.
LA  - eng
PT  - Case Reports
PT  - Validation Study
DEP - 20210909
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
SB  - IM
MH  - Endoscopy/adverse effects/standards
MH  - Esthesioneuroblastoma, Olfactory/physiopathology/radiotherapy/*surgery
MH  - Female
MH  - Humans
MH  - Male
MH  - Nasal Cavity/surgery
MH  - Nose Neoplasms/physiopathology/radiotherapy/*surgery
MH  - Olfaction Disorders/etiology/*physiopathology/*psychology
MH  - Radiotherapy, Adjuvant
MH  - Retrospective Studies
MH  - Smell/*physiology
OTO - NOTNLM
OT  - Endoscopic surgery
OT  - Esthesioneuroblastoma
OT  - Olfaction
OT  - Sinonasal tumor
OT  - Skull base surgery
OT  - Smell preservation
COIS- Declaration of Competing Interest There are no conflicts of interests in this 
      study. This study was approved by the Ethics Committee of Kyoto University 
      Hospital (R-2805).
EDAT- 2021/09/14 06:00
MHDA- 2022/07/12 06:00
CRDT- 2021/09/13 05:49
PHST- 2021/04/02 00:00 [received]
PHST- 2021/07/09 00:00 [revised]
PHST- 2021/08/26 00:00 [accepted]
PHST- 2021/09/14 06:00 [pubmed]
PHST- 2022/07/12 06:00 [medline]
PHST- 2021/09/13 05:49 [entrez]
AID - S0385-8146(21)00230-3 [pii]
AID - 10.1016/j.anl.2021.08.007 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2022 Dec;49(6):1088-1092. doi: 10.1016/j.anl.2021.08.007. 
      Epub 2021 Sep 9.