PMID- 34511969
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220426
IS  - 1178-7031 (Print)
IS  - 1178-7031 (Electronic)
IS  - 1178-7031 (Linking)
VI  - 14
DP  - 2021
TI  - Overexpression of Lin28a Aggravates Psoriasis-Like Phenotype by Regulating the 
      Proliferation and Differentiation of Keratinocytes.
PG  - 4299-4312
LID - 10.2147/JIR.S312963 [doi]
AB  - PURPOSE: Psoriasis is a common and well-studied autoimmune skin disease, which is 
      characterized by plaques. The formation of psoriasis plaques occurs through the 
      hyperproliferation and abnormal differentiation of keratinocytes, infiltration of 
      numerous immune cells into the dermis, increased subepidermal angiogenesis, and 
      various autoimmune-associated cytokines and chemokines. According to previous 
      research, Lin28 regulates the let-7 family, and let-7b is associated with 
      psoriasis. However, the link between Lin28 and psoriasis is unclear. In this 
      study, an association was identified between Lin28a and psoriasis progression, 
      which promoted the pathological characteristic of psoriasis in epidermal 
      keratinocytes. PATIENTS AND METHODS: This study aims to investigate the role of 
      Lin28a and its underlying mechanism in psoriasis through in vivo and in vitro 
      models, which include the Lin28a-overexpressing transgenic (TG) mice and 
      Lin28a-overexpressing human keratinocyte (HaCaT) cell lines, respectively. 
      RESULTS: In vivo and in vitro results revealed that overexpression of Lin28a 
      downregulated microRNA let-7 expression levels and caused hyperproliferation and 
      abnormal differentiation in keratinocytes. In imiquimod (IMQ)-induced 
      psoriasis-like inflammation, Lin28a overexpressing transgenic (TG) mice exhibited 
      more severe symptoms of psoriasis. CONCLUSION: Mechanistically, Lin28a 
      exacerbated psoriasis-like inflammation through the activation of the 
      extracellular-signal-regulated kinase (ERK) and signal transducer and activator 
      of transcription 3 signaling (STAT 3) by targeting proinflammatory cytokine 
      interleukin-6 (IL-6).
CI  - (c) 2021 Jang et al.
FAU - Jang, Soyeon
AU  - Jang S
AD  - School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook 
      National University, Daegu, Korea.
FAU - Jang, Soyoung
AU  - Jang S
AD  - School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook 
      National University, Daegu, Korea.
FAU - Kim, Si-Yong
AU  - Kim SY
AD  - School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook 
      National University, Daegu, Korea.
FAU - Ko, Jiwon
AU  - Ko J
AD  - School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook 
      National University, Daegu, Korea.
FAU - Kim, Eungyung
AU  - Kim E
AD  - Department of Animal Science and Biotechnology, Kyungpook National University, 
      Daegu, Korea.
FAU - Park, Ji Yeong
AU  - Park JY
AD  - School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook 
      National University, Daegu, Korea.
FAU - Hyung, Hyejin
AU  - Hyung H
AD  - School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook 
      National University, Daegu, Korea.
FAU - Lee, Jin Hong
AU  - Lee JH
AD  - School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook 
      National University, Daegu, Korea.
FAU - Lim, Su-Geun
AU  - Lim SG
AD  - School of Life Science, Kyungpook National University, Daegu, Korea.
FAU - Park, Sijun
AU  - Park S
AUID- ORCID: 0000-0002-8791-8249
AD  - School of Life Science, Kyungpook National University, Daegu, Korea.
FAU - Yi, Junkoo
AU  - Yi J
AD  - Gyeongsangbukdo Livestock Research Institute, Yeongju, Korea.
FAU - Lee, Heon-Jin
AU  - Lee HJ
AUID- ORCID: 0000-0002-1911-5014
AD  - Department of Microbiology and Immunology, School of Dentistry, Kyungpook 
      National University, Daegu, 41940, Korea.
FAU - Kim, Myoung Ok
AU  - Kim MO
AD  - Department of Animal Science and Biotechnology, Kyungpook National University, 
      Daegu, Korea.
FAU - Lee, Hyun-Shik
AU  - Lee HS
AD  - School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook 
      National University, Daegu, Korea.
FAU - Ryoo, Zae Young
AU  - Ryoo ZY
AUID- ORCID: 0000-0001-6993-3624
AD  - School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook 
      National University, Daegu, Korea.
LA  - eng
PT  - Journal Article
DEP - 20210830
PL  - New Zealand
TA  - J Inflamm Res
JT  - Journal of inflammation research
JID - 101512684
EIN - J Inflamm Res. 2021 Oct 22;14:5473-5474. PMID: 34712058
PMC - PMC8415766
OTO - NOTNLM
OT  - Lin28a
OT  - keratinocyte
OT  - let-7
OT  - psoriasis
COIS- The authors report no conflicts of interest in this work.
EDAT- 2021/09/14 06:00
MHDA- 2021/09/14 06:01
PMCR- 2021/08/30
CRDT- 2021/09/13 06:37
PHST- 2021/03/29 00:00 [received]
PHST- 2021/08/06 00:00 [accepted]
PHST- 2021/09/13 06:37 [entrez]
PHST- 2021/09/14 06:00 [pubmed]
PHST- 2021/09/14 06:01 [medline]
PHST- 2021/08/30 00:00 [pmc-release]
AID - 312963 [pii]
AID - 10.2147/JIR.S312963 [doi]
PST - epublish
SO  - J Inflamm Res. 2021 Aug 30;14:4299-4312. doi: 10.2147/JIR.S312963. eCollection 
      2021.