PMID- 34512570
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210914
IS  - 1664-302X (Print)
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 12
DP  - 2021
TI  - Evasion of Antiviral Innate Immunity by Porcine Reproductive and Respiratory 
      Syndrome Virus.
PG  - 693799
LID - 10.3389/fmicb.2021.693799 [doi]
LID - 693799
AB  - Innate immunity is the front line for antiviral immune responses and bridges 
      adaptive immunity against viral infections. However, various viruses have evolved 
      many strategies to evade host innate immunity. A typical virus is the porcine 
      reproductive and respiratory syndrome virus (PRRSV), one of the most globally 
      devastating viruses threatening the swine industry worldwide. PRRSV engages 
      several strategies to evade the porcine innate immune responses. This review 
      focus on the underlying mechanisms employed by PRRSV to evade pattern recognition 
      receptors signaling pathways, type I interferon (IFN-alpha/beta) receptor 
      (IFNAR)-JAK-STAT signaling pathway, and interferon-stimulated genes. Deciphering 
      the antiviral immune evasion mechanisms by PRRSV will enhance our understanding 
      of PRRSV's pathogenesis and help us to develop more effective methods to control 
      and eliminate PRRSV.
CI  - Copyright (c) 2021 Wang, Sun, Zhang, Wang, Zhan, Tian, Cai, Su and Tang.
FAU - Wang, Tong-Yun
AU  - Wang TY
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
FAU - Sun, Ming-Xia
AU  - Sun MX
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
FAU - Zhang, Hong-Liang
AU  - Zhang HL
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
FAU - Wang, Gang
AU  - Wang G
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
FAU - Zhan, Guoqing
AU  - Zhan G
AD  - Department of Immunology, School of Basic Medical Sciences, Fujian Medical 
      University, Fuzhou, China.
AD  - Department of Infectious Disease, Renmin Hospital, Hubei University of Medicine, 
      Shiyan, China.
FAU - Tian, Zhi-Jun
AU  - Tian ZJ
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
FAU - Cai, Xue-Hui
AU  - Cai XH
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
FAU - Su, Chenhe
AU  - Su C
AD  - Department of Immunology, School of Basic Medical Sciences, Fujian Medical 
      University, Fuzhou, China.
FAU - Tang, Yan-Dong
AU  - Tang YD
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210623
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC8430839
OTO - NOTNLM
OT  - ISGs
OT  - JAK-STAT
OT  - PRRSV
OT  - PRRs
OT  - antiviral innate immunity
OT  - immune evasion
OT  - interferon
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/09/14 06:00
MHDA- 2021/09/14 06:01
PMCR- 2021/06/23
CRDT- 2021/09/13 06:43
PHST- 2021/04/12 00:00 [received]
PHST- 2021/04/28 00:00 [accepted]
PHST- 2021/09/13 06:43 [entrez]
PHST- 2021/09/14 06:00 [pubmed]
PHST- 2021/09/14 06:01 [medline]
PHST- 2021/06/23 00:00 [pmc-release]
AID - 10.3389/fmicb.2021.693799 [doi]
PST - epublish
SO  - Front Microbiol. 2021 Jun 23;12:693799. doi: 10.3389/fmicb.2021.693799. 
      eCollection 2021.