PMID- 34512748
OWN - NLM
STAT- MEDLINE
DCOM- 20220204
LR  - 20220204
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2021
DP  - 2021
TI  - Increased Homotopic Connectivity in the Prefrontal Cortex Modulated by Olanzapine 
      Predicts Therapeutic Efficacy in Patients with Schizophrenia.
PG  - 9954547
LID - 10.1155/2021/9954547 [doi]
LID - 9954547
AB  - BACKGROUND: Previous studies have revealed the abnormalities in homotopic 
      connectivity in schizophrenia. However, the relationship of these deficits to 
      antipsychotic treatment in schizophrenia remains unclear. This study explored the 
      effects of antipsychotic therapy on brain homotopic connectivity and whether the 
      homotopic connectivity of these regions might predict individual treatment 
      response in schizophrenic patients. METHODS: A total of 21 schizophrenic patients 
      and 20 healthy controls were scanned by the resting-state functional magnetic 
      resonance imaging. The patients received olanzapine treatment and were scanned at 
      two time points. Voxel-mirrored homotopic connectivity (VMHC) and pattern 
      classification techniques were applied to analyze the imaging data. RESULTS: 
      Schizophrenic patients presented significantly decreased VMHC in the temporal and 
      inferior frontal gyri, medial prefrontal cortex (MPFC), and motor and low-level 
      sensory processing regions (including the fusiform gyrus and cerebellum lobule 
      VI) relative to healthy controls. The VMHC in the superior/middle MPFC was 
      significantly increased in the patients after eight weeks of treatment. Support 
      vector regression (SVR) analyses revealed that VMHC in the superior/middle MPFC 
      at baseline can predict the symptomatic improvement of the positive and negative 
      syndrome scale after eight weeks of treatment. CONCLUSIONS: This study 
      demonstrated that olanzapine treatment may normalize decreased homotopic 
      connectivity in the superior/middle MPFC in schizophrenic patients. The VMHC in 
      the superior/middle MPFC may predict individual response for antipsychotic 
      therapy. The findings of this study conduce to the comprehension of the therapy 
      effects of antipsychotic medications on homotopic connectivity in schizophrenia.
CI  - Copyright (c) 2021 Xiaoxiao Shan et al.
FAU - Shan, Xiaoxiao
AU  - Shan X
AD  - National Clinical Research Center for Mental Disorders and Department of 
      Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 
      410011 Hunan, China.
FAU - Liao, Rongyuan
AU  - Liao R
AD  - The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 
      China.
FAU - Ou, Yangpan
AU  - Ou Y
AD  - National Clinical Research Center for Mental Disorders and Department of 
      Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 
      410011 Hunan, China.
FAU - Ding, Yudan
AU  - Ding Y
AD  - National Clinical Research Center for Mental Disorders and Department of 
      Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 
      410011 Hunan, China.
FAU - Liu, Feng
AU  - Liu F
AD  - Department of Radiology, Tianjin Medical University General Hospital, Tianjin 
      300000, China.
FAU - Chen, Jindong
AU  - Chen J
AD  - National Clinical Research Center for Mental Disorders and Department of 
      Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 
      410011 Hunan, China.
FAU - Zhao, Jingping
AU  - Zhao J
AD  - National Clinical Research Center for Mental Disorders and Department of 
      Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 
      410011 Hunan, China.
FAU - He, Yiqun
AU  - He Y
AUID- ORCID: 0000-0003-4123-5095
AD  - The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, 
      China.
FAU - Guo, Wenbin
AU  - Guo W
AUID- ORCID: 0000-0002-1626-2465
AD  - National Clinical Research Center for Mental Disorders and Department of 
      Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 
      410011 Hunan, China.
AD  - Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, 528000 
      Guangdong, China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20210901
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
RN  - 0 (Antipsychotic Agents)
RN  - N7U69T4SZR (Olanzapine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antipsychotic Agents/pharmacology/*therapeutic use
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Nerve Net/*diagnostic imaging/drug effects
MH  - Olanzapine/pharmacology/*therapeutic use
MH  - Predictive Value of Tests
MH  - Prefrontal Cortex/*diagnostic imaging/drug effects
MH  - Schizophrenia/*diagnostic imaging/drug therapy
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC8429031
COIS- We declare that there is no any potential conflict of interest for this study.
EDAT- 2021/09/14 06:00
MHDA- 2022/02/05 06:00
PMCR- 2021/09/01
CRDT- 2021/09/13 06:44
PHST- 2021/03/19 00:00 [received]
PHST- 2021/08/08 00:00 [revised]
PHST- 2021/08/18 00:00 [accepted]
PHST- 2021/09/13 06:44 [entrez]
PHST- 2021/09/14 06:00 [pubmed]
PHST- 2022/02/05 06:00 [medline]
PHST- 2021/09/01 00:00 [pmc-release]
AID - 10.1155/2021/9954547 [doi]
PST - epublish
SO  - Neural Plast. 2021 Sep 1;2021:9954547. doi: 10.1155/2021/9954547. eCollection 
      2021.