PMID- 34512884
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210914
IS  - 1948-9358 (Print)
IS  - 1948-9358 (Electronic)
IS  - 1948-9358 (Linking)
VI  - 12
IP  - 8
DP  - 2021 Aug 15
TI  - Gut microbiota as a target for prevention and treatment of type 2 diabetes: 
      Mechanisms and dietary natural products.
PG  - 1146-1163
LID - 10.4239/wjd.v12.i8.1146 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is among the most remarkable public health 
      concerns globally. Accumulating research evidence documents that alteration of 
      gut microbiota has an indispensable role in the onset and progression of obesity 
      and T2DM. A reduced microbial diversity is linked to insulin resistance and 
      energy metabolism, especially for the rise of the Firmicutes/Bacteroidetes ratio. 
      Changes in metabolites followed by the gut dysbacteriosis are linked to the 
      presence of T2DM. Moreover, endotoxin leakage and gut permeability caused by gut 
      dysbacteriosis is more of a trigger for the onset and progression of T2DM. 
      Research documents that natural products are remarkable arsenals of bioactive 
      agents for the discovery of anti-T2DM drugs. Many studies have elucidated that 
      the possible mechanisms of the anti-T2DM effects of natural products are 
      remarkably linked to its regulation on the composition of gut microflora and the 
      successive changes in metabolites directly or indirectly. This review presents a 
      brief overview of the gut microbiota in T2DM and several relevant mechanisms, 
      including short-chain fatty acids, biosynthesis and metabolism of branched-chain 
      fatty acids, trimethylamine N-oxide, bile acid signaling, endotoxin leakage, and 
      gut permeability, and describes how dietary natural products can improve T2DM via 
      the gut microbiota.
CI  - (c)The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Xia, Fan
AU  - Xia F
AD  - Department of Pharmacy, The Seventh Affiliated Hospital of Sun Yat-Sen 
      University, Shenzhen 518107, Guangdong Province, China.
FAU - Wen, Lu-Ping
AU  - Wen LP
AD  - Department of Pharmacy, The Seventh Affiliated Hospital of Sun Yat-Sen 
      University, Shenzhen 518107, Guangdong Province, China.
FAU - Ge, Bing-Chen
AU  - Ge BC
AD  - Department of Pharmacy, The Seventh Affiliated Hospital of Sun Yat-Sen 
      University, Shenzhen 518107, Guangdong Province, China.
FAU - Li, Yu-Xin
AU  - Li YX
AD  - Department of Pharmacology, Guangdong Medical University, Zhanjiang 524023, 
      Guangdong Province, China.
FAU - Li, Fang-Ping
AU  - Li FP
AD  - Department of Endocrinology, The Seventh Affiliated Hospital, Sun Yat-Sen 
      University, Shenzhen 518107, Guangdong Province, China.
FAU - Zhou, Ben-Jie
AU  - Zhou BJ
AD  - Department of Pharmacy, The Seventh Affiliated Hospital of Sun Yat-Sen 
      University, Shenzhen 518107, Guangdong Province, China. zhoubj163@163.com.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Diabetes
JT  - World journal of diabetes
JID - 101547524
PMC - PMC8394227
OTO - NOTNLM
OT  - Diabetes
OT  - Dietary natural products
OT  - Gut microbiota
OT  - Mechanisms
OT  - Metabolites
OT  - Obesity
EDAT- 2021/09/14 06:00
MHDA- 2021/09/14 06:01
PMCR- 2021/08/15
CRDT- 2021/09/13 06:46
PHST- 2021/01/28 00:00 [received]
PHST- 2021/05/10 00:00 [revised]
PHST- 2021/07/05 00:00 [accepted]
PHST- 2021/09/13 06:46 [entrez]
PHST- 2021/09/14 06:00 [pubmed]
PHST- 2021/09/14 06:01 [medline]
PHST- 2021/08/15 00:00 [pmc-release]
AID - 10.4239/wjd.v12.i8.1146 [doi]
PST - ppublish
SO  - World J Diabetes. 2021 Aug 15;12(8):1146-1163. doi: 10.4239/wjd.v12.i8.1146.