PMID- 34514872
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 1548-9221 (Electronic)
IS  - 1548-9221 (Linking)
VI  - 36
IP  - 6
DP  - 2021 Nov 1
TI  - Role of mTOR Signaling for Tubular Function and Disease.
PG  - 350-358
LID - 10.1152/physiol.00021.2021 [doi]
AB  - The mechanistic target of rapamycin (mTOR) forms two distinct intracellular 
      multiprotein complexes that control a multitude of intracellular processes linked 
      to metabolism, proliferation, actin cytoskeleton, and survival. Recent studies 
      have identified the importance of these complexes for transport regulation of 
      ions and nutrients along the entire nephron. First reports could link altered 
      activity of these complexes to certain disease entities, i.e. diabetic 
      nephropathy, acute kidney injury or hyperkalemia.
FAU - Grahammer, Florian
AU  - Grahammer F
AD  - Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, 
      Germany.
FAU - Huber, Tobias B
AU  - Huber TB
AD  - Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, 
      Germany.
FAU - Artunc, Ferruh
AU  - Artunc F
AUID- ORCID: 0000-0002-3777-9316
AD  - Department of Internal Medicine, Division of Endocrinology, Diabetology, and 
      Nephrology, University Hospital Tubingen, Tubingen, Germany.
AD  - Institute of Diabetes Research and Metabolic Diseases, Helmholtz Center Munich, 
      University Tubingen, Tubingen, Germany.
AD  - German Center for Diabetes Research, University Tubingen, Tubingen, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210913
PL  - United States
TA  - Physiology (Bethesda)
JT  - Physiology (Bethesda, Md.)
JID - 101208185
RN  - 0 (Multiprotein Complexes)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 2)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
MH  - Humans
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Mechanistic Target of Rapamycin Complex 2
MH  - Multiprotein Complexes
MH  - *Sirolimus
MH  - *TOR Serine-Threonine Kinases
OTO - NOTNLM
OT  - ENaC
OT  - ROMK
OT  - endocytosis
OT  - mTOR
OT  - proximal tubule
EDAT- 2021/09/14 06:00
MHDA- 2022/02/01 06:00
CRDT- 2021/09/13 08:55
PHST- 2021/09/14 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/09/13 08:55 [entrez]
AID - 10.1152/physiol.00021.2021 [doi]
PST - ppublish
SO  - Physiology (Bethesda). 2021 Nov 1;36(6):350-358. doi: 10.1152/physiol.00021.2021. 
      Epub 2021 Sep 13.