PMID- 34515452
OWN - NLM
STAT- MEDLINE
DCOM- 20220119
LR  - 20220119
IS  - 2724-5365 (Electronic)
IS  - 2724-5985 (Linking)
VI  - 67
IP  - 4
DP  - 2021 Dec
TI  - Microbiota and the irritable bowel syndrome.
PG  - 377-384
LID - 10.23736/S2724-5985.21.02923-5 [doi]
AB  - Gut microbiota plays a vital role in human health. The number of microorganisms 
      inhabiting the gastrointestinal (GI) tract has been estimated to exceed 10(13). 
      The dominant genera in the human intestine are Firmicutes (more than 180 species 
      of Lactobacillus), Actinobacteria (among others the Bifidobacteriae), 
      Bacteroidetes (the most important is B. fragilis) and Proteobacteria (E. coli, 
      Salmonella, Yersinia, Shigella, Vibrio, Haemophilus, etc.), but the composition 
      of the flora varies individually, as well as in relation to factors such as host 
      genetics, stress, diet, antibiotics and early childhood experiences. Irritable 
      bowel syndrome (IBS) is one of the most common functional gastrointestinal 
      disorders (FGIDs), which has now been renamed disorders of gut-brain interaction, 
      which affect a large number of people worldwide. It is characterized by abdominal 
      pain and altered bowel habits in the absence of obvious anatomic or physiologic 
      abnormalities. It poses a negative economic impact to the global health care 
      system in addition to reducing the quality of life in patients. The 
      pathophysiology of IBS is not fully understood. In IBS subjects gut microbiota 
      relative to healthy controls was observed with an increase in Enterobacteriaceae, 
      Ruminococcus, Clostridium, Dorea species and a decrease of Lactobacillus, 
      Bifidobacterium, and Faecalibacterium species. IBS with diarrhea predominance 
      (IBS-D) IBS with mixed bowel habits (IBS-M) share similarities in the microbial 
      profile. Recent studies suggest that perturbations within "brain-gut-microbiota" 
      axis may lead to IBS development. The aim of this review was to highlight the 
      potential role of gut microbiota on pathophysiological mechanisms underlying IBS.
FAU - Sabo, Cristina M
AU  - Sabo CM
AD  - Second Department of Internal Medicine, Iuliu Hatieganu University of Medicine 
      and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania - Marica.Cristina@umfcluj.ro.
FAU - Dumitrascu, Dan L
AU  - Dumitrascu DL
AD  - Second Department of Internal Medicine, Iuliu Hatieganu University of Medicine 
      and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210913
PL  - Italy
TA  - Minerva Gastroenterol (Torino)
JT  - Minerva gastroenterology
JID - 101777280
SB  - IM
MH  - Child, Preschool
MH  - Diarrhea
MH  - Escherichia coli
MH  - *Gastrointestinal Microbiome
MH  - Humans
MH  - *Irritable Bowel Syndrome
MH  - Quality of Life
EDAT- 2021/09/14 06:00
MHDA- 2022/01/20 06:00
CRDT- 2021/09/13 10:54
PHST- 2021/09/14 06:00 [pubmed]
PHST- 2022/01/20 06:00 [medline]
PHST- 2021/09/13 10:54 [entrez]
AID - S2724-5985.21.02923-5 [pii]
AID - 10.23736/S2724-5985.21.02923-5 [doi]
PST - ppublish
SO  - Minerva Gastroenterol (Torino). 2021 Dec;67(4):377-384. doi: 
      10.23736/S2724-5985.21.02923-5. Epub 2021 Sep 13.