PMID- 34515850
OWN - NLM
STAT- MEDLINE
DCOM- 20220215
LR  - 20220215
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 59
IP  - 2
DP  - 2022 Feb
TI  - Should PRECISE-DAPT be included for long-term prognostic stratification of 
      diabetic patients with NSTEACS?
PG  - 163-170
LID - 10.1007/s00592-021-01792-w [doi]
AB  - AIMS: There are insufficient data regarding risk scores validation in patients 
      with diabetes mellitus and non-ST elevation acute coronary syndrome (NSTEACS). We 
      performed a diabetes mellitus-specific analysis of cardiovascular outcomes after 
      NSTEACS. We tested the predictive power of the Global Registry of Acute Coronary 
      Events (GRACE) and PREdicting bleeding Complications In patients undergoing Stent 
      implantation and subsEquent Dual Anti-Platelet Therapy (PRECISE-DAPT) scores. 
      METHODS: This work is a retrospective analysis that included 7,415 consecutive 
      NSTEACS patients from two Spanish Universitarian hospitals between the years 2003 
      and 2017. The area under the ROC curve among with and without diabetes mellitus 
      patients was calculated, to evaluate the predictive power of both scores.  
      RESULTS: Among the study participants, 2124 patients (28.0%) were diabetic. The 
      median follow-up was 54,3 months (IQR 24,7-80,0 months). Diabetic patients were 
      more women (30.5% vs. 25.7%) and older (70.0 +/- 10.8 vs. 65.3 +/- 13.2 years old); 
      they had higher GRACE (146 +/- 36 vs. 137 +/- 36), PRECISE-DAPT (15 +/- 7 vs. 18 +/- 9) 
      at admission. Early invasive coronary angiography (</= 24 h after admission) was 
      performed more frequently in non-diabetic. We tested the predictive power of the 
      GRACE and PRECISE-DAPT risk scores among diabetic and non-diabetic. PRECISE-DAPT 
      risk score showed a good predictive power for all-cause mortality, cardiovascular 
      mortality and MACE in diabetic admitted with NSTEACS, without differences 
      compared to non-diabetic. CONCLUSIONS: PRECISE-DAPT risk score has an appropriate 
      predictive power in diabetic patients admitted with NSTEACS compared to 
      non-diabetic NSTEACS. However, GRACE would be predictive worse in diabetic during 
      long-term follow-up in a large contemporary registry.
CI  - (c) 2021. Springer-Verlag Italia S.r.l., part of Springer Nature.
FAU - Garcia-Rodeja Arias, Federico
AU  - Garcia-Rodeja Arias F
AUID- ORCID: 0000-0003-0577-9239
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, Rua da Choupana s/n. 15703, Santiago de Compostela, Spain. 
      fedeg-r@hotmail.com.
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain. fedeg-r@hotmail.com.
FAU - Alvarez Alvarez, Belen
AU  - Alvarez Alvarez B
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, Rua da Choupana s/n. 15703, Santiago de Compostela, Spain.
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
FAU - Gonzalez Ferrero, Teba
AU  - Gonzalez Ferrero T
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, Rua da Choupana s/n. 15703, Santiago de Compostela, Spain.
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
FAU - Martinon Martinez, Jesus
AU  - Martinon Martinez J
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, Rua da Choupana s/n. 15703, Santiago de Compostela, Spain.
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
FAU - Otero Garcia, Oscar
AU  - Otero Garcia O
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, Rua da Choupana s/n. 15703, Santiago de Compostela, Spain.
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
FAU - Tasende Rey, Pablo
AU  - Tasende Rey P
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, Rua da Choupana s/n. 15703, Santiago de Compostela, Spain.
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
FAU - Cacho Antonio, Carla Eugenia
AU  - Cacho Antonio CE
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, Rua da Choupana s/n. 15703, Santiago de Compostela, Spain.
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
FAU - Abou Jokh Casas, Charigan
AU  - Abou Jokh Casas C
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, Rua da Choupana s/n. 15703, Santiago de Compostela, Spain.
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
FAU - Zuazola, Pilar
AU  - Zuazola P
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
AD  - Cardiology Department, University Hospital of San Juan, Alicante, Spain.
FAU - Jimenez Ramos, Victor
AU  - Jimenez Ramos V
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, Rua da Choupana s/n. 15703, Santiago de Compostela, Spain.
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
FAU - Cordero, Alberto
AU  - Cordero A
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
AD  - Cardiology Department, University Hospital of San Juan, Alicante, Spain.
FAU - Escribano, David
AU  - Escribano D
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
AD  - Cardiology Department, University Hospital of San Juan, Alicante, Spain.
FAU - Cid Alvarez, Belen
AU  - Cid Alvarez B
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, Rua da Choupana s/n. 15703, Santiago de Compostela, Spain.
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
FAU - Iglesias Alvarez, Diego
AU  - Iglesias Alvarez D
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, Rua da Choupana s/n. 15703, Santiago de Compostela, Spain.
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
FAU - Agra Bermejo, Rosa Maria
AU  - Agra Bermejo RM
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, Rua da Choupana s/n. 15703, Santiago de Compostela, Spain.
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
FAU - Rigueiro Veloso, Pedro
AU  - Rigueiro Veloso P
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, Rua da Choupana s/n. 15703, Santiago de Compostela, Spain.
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
FAU - Garcia Acuna, Jose Maria
AU  - Garcia Acuna JM
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, Rua da Choupana s/n. 15703, Santiago de Compostela, Spain.
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
FAU - Gude Sampedro, Francisco
AU  - Gude Sampedro F
AD  - Epidemiology Department, University Clinical Hospital of Santiago de Compostela, 
      Santiago de Compostela, Spain.
FAU - Gonzalez Juanatey, Jose Ramon
AU  - Gonzalez Juanatey JR
AD  - Cardiology Department, Complejo Hospitalario Universitario de Santiago de 
      Compostela, Rua da Choupana s/n. 15703, Santiago de Compostela, Spain.
AD  - Biomedical Research Networking Center On Cardiovascular Diseases (CIBERCV), 
      Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20210913
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
RN  - 0 (Platelet Aggregation Inhibitors)
SB  - IM
MH  - *Acute Coronary Syndrome/complications/diagnosis
MH  - Aged
MH  - *Diabetes Mellitus/epidemiology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *Percutaneous Coronary Intervention
MH  - Platelet Aggregation Inhibitors
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - GRACE
OT  - Guidelines
OT  - Long-term prognosis
OT  - NSTEACS
OT  - PRECISE-DAPT
EDAT- 2021/09/14 06:00
MHDA- 2022/02/16 06:00
CRDT- 2021/09/13 12:31
PHST- 2021/07/01 00:00 [received]
PHST- 2021/08/24 00:00 [accepted]
PHST- 2021/09/14 06:00 [pubmed]
PHST- 2022/02/16 06:00 [medline]
PHST- 2021/09/13 12:31 [entrez]
AID - 10.1007/s00592-021-01792-w [pii]
AID - 10.1007/s00592-021-01792-w [doi]
PST - ppublish
SO  - Acta Diabetol. 2022 Feb;59(2):163-170. doi: 10.1007/s00592-021-01792-w. Epub 2021 
      Sep 13.